DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and npp-20

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_500086.1	Gene:	npp-20 / 176957	WormBaseID:	WBGene00003806	Length:	313	Species:	Caenorhabditis elegans

Alignment Length:	310	Identity:	87/310 - (28%)
Similarity:	143/310 - (46%)	Gaps:	37/310 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSWAHPEFG 71
            |...|:|.|||...:.||.|:|||.||:.|||::....|:....:....|||.:|:||||||::|
Worm     8 IDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGQSYPMAELVGHSGPVWKVSWAHPKYG 72

  Fly    72 QVVATCSFDRTASVWEEVIGEKVSSTNTPTRRWVRRTTLVDSRTSVTDVEFAPKYLGLLLATASA 136
            .::|:.|:|:...:|.|..|           ||.:.........|.|.|.|||...||:||:|||
Worm    73 GLLASASYDKKVIIWNEQQG-----------RWQKAYEWAAHEASTTCVAFAPHQYGLMLASASA 126

  Fly   137 DGIIRIYEAPDIMNLSQWPVQHEISNKLP------LSCLSW---NTSTYMVTQLLAAGSDEAATP 192
            ||.|.|....:..|  :|     ||:|:.      ::.:.|   :.......:|::||:|:
Worm   127 DGDIGILRYDNSSN--EW-----ISSKIQKCHEQGVNSVCWAPGSADPAAKKRLVSAGNDK---- 180

  Fly   193 TGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNLRGVTDATD 257
              .|.::|:.:.:.:.:...|:...||.|.:.|:.|......|.:.....:..:|..|.....|:
Worm   181 --NVKIWAFDDATNEWILEKTLAGHTDFVREAAWCPVTNNGQHTIVSCGMEGNLVLFRTSNIETE 243

  Fly   258 ISKLDIQTIKFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQW 307
            ..|..:    .....|.::...::...:.|...|||..:.:||.|...||
Worm   244 EWKAKL----LETAPCALYHSSFSPCGSFLSVAGDDNVITIWRENLQGQW 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	81/297 (27%)
		WD40 repeat	16..55	CDD:293791	14/38 (37%)
		WD40 repeat	60..98	CDD:293791	14/37 (38%)
		WD40 repeat	118..159	CDD:293791	18/40 (45%)
		WD40 repeat	166..212	CDD:293791	7/48 (15%)
		WD40 repeat	221..267	CDD:293791	8/45 (18%)
		WD40 repeat	275..299	CDD:293791	4/23 (17%)
npp-20	NP_500086.1	WD40	4..>285	CDD:225201	84/304 (28%)
		WD40	12..282	CDD:295369	81/297 (27%)
		WD40 repeat	61..102	CDD:293791	16/51 (31%)
		WD40 repeat	108..150	CDD:293791	21/48 (44%)
		WD40 repeat	155..201	CDD:293791	8/51 (16%)
		WD40 repeat	212..250	CDD:293791	6/41 (15%)
		WD40 repeat	257..288	CDD:293791	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920