DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup44A and Seh1l

DIOPT Version :9

Sequence 1:	NP_610343.1	Gene:	Nup44A / 35762	FlyBaseID:	FBgn0033247	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001381923.1	Gene:	Seh1l / 100911798	RGDID:	6490353	Length:	360	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	193/345 - (55%)
Similarity:	254/345 - (73%)	Gaps:	16/345 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFDVEPIIADHKDVIHDVVFDYYGRRMATCSSDQTVKIWDEDGQGKWNVTSSWKAHSGSIWRVSW 65
            ||....|.|||||:||||.||::|||||||||||:||:||:...|.|:.|:|||.||||:|||:|
  Rat     1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65

  Fly    66 AHPEFGQVVATCSFDRTASVWEEVIGEKVSSTNTPTR---RWVRRTTLVDSRTSVTDVEFAPKYL 127
            ||||||||:|:|||||||:||||::||    :|...|   .||:||||||||||||||:||||::
  Rat    66 AHPEFGQVLASCSFDRTAAVWEEIVGE----SNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126

  Fly   128 GLLLATASADGIIRIYEAPDIMNLSQWPVQHEISNKLPLSCLSWNTSTYMV-TQLLAAGSDEAA- 190
            ||:|||.|||||:|:|||||:||||||.:|||||.||..||:|||.|:... ..::|.|||:::
  Rat   127 GLMLATCSADGIVRVYEAPDVMNLSQWSLQHEISCKLCCSCISWNPSSSRAHPPMIAVGSDDSSP 191

  Fly   191 TPTGKVFLFAYSENSRKCVKIDTVNDITDPVTDVAFAPNAGRTFHMLAVASKDLYIVNLRGV--- 252
            ....||.:|.|:||:||..|.:|:..:||||.|:|||||.||:||:||:|:||:.|..|:.|
  Rat   192 NSMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKE 256

  Fly   253 -TDATDISKLDIQTI-KFSEHNCPVWRVCWNMLATMLISTGDDGCVRLWRMNYNRQWRCAAVLKA 315
             |.:...:|.:|..: :|..||..||||.||:..|:|.|:|||||||||:.||...|:|..:||.
  Rat   257 LTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKG 321

  Fly   316 EGS--GPTYEPAPPTPTLAT 333
            .||  ..:.:....||:|::
  Rat   322 NGSPVNGSSQLGNSTPSLSS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup44A	NP_610343.1	WD40	11..300	CDD:392136	176/298 (59%)
		WD40 repeat	16..55	CDD:293791	25/38 (66%)
		WD40 repeat	60..98	CDD:293791	26/37 (70%)
		WD40 repeat	118..159	CDD:293791	30/40 (75%)
		WD40 repeat	166..212	CDD:293791	19/47 (40%)
		WD40 repeat	221..267	CDD:293791	22/50 (44%)
		WD40 repeat	275..299	CDD:293791	16/23 (70%)
Seh1l	NP_001381923.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68701
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010