DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACC and ACC1

DIOPT Version :9

Sequence 1:NP_610342.1 Gene:ACC / 35761 FlyBaseID:FBgn0033246 Length:2482 Species:Drosophila melanogaster
Sequence 2:NP_014413.1 Gene:ACC1 / 855750 SGDID:S000005299 Length:2233 Species:Saccharomyces cerevisiae


Alignment Length:2335 Identity:1007/2335 - (43%)
Similarity:1443/2335 - (61%) Gaps:182/2335 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 PLKMQNDVRQNGDISERRKRLRPSMSRGTGLG---QDRHQDRDFHIATTEEFVKRFGGTRVINKV 263
            |.||:.::.   :.|||...|     .|..:|   .|:.::     :...:|||..||..||:|:
Yeast    11 PQKMEYEIT---NYSERHTEL-----PGHFIGLNTVDKLEE-----SPLRDFVKSHGGHTVISKI 62

  Fly   264 LIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNN 328
            |||||||||||.:||:|:||||.|.::|.::||.|.|||||:||||||:|||.|:.||||:||||
Yeast    63 LIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNN 127

  Fly   329 YANVELIVDIALRTQVQAVWAGWGHASENPKLPELL--HKEGLVFLGPPERAMWALGDKVASSIV 391
            ||||:||||||.|..|.|||||||||||||.|||.|  .|..::|:|||..||.:||||::|:||
Yeast   128 YANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIV 192

  Fly   392 AQTAEIPTLPWSGSDLKAQYSGKK---IKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGG 453
            ||:|::|.:||||:.:...:..:|   :.:..:::.:||.|:.|.||....:|||||||||||||
Yeast   193 AQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGG 257

  Fly   454 GGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQ 518
            ||||||:|:..|:|..|:.|...|:||||||:||||..||||||||||||||..|||||||||:|
Yeast   258 GGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQ 322

  Fly   519 RRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYD-PEGRYFFLELNPRLQVE 582
            |||||||||||..:|:.|.|.:||||||||.|:|||||||||||||. .:|:::|||||||||||
Yeast   323 RRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVE 387

  Fly   583 HPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFE-------NPPNKPRPSG 640
            ||.||||:.||||||||||.||||::|:.|||.|||.:|..:|.||||       ....:|.|.|
Yeast   388 HPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKG 452

  Fly   641 HVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQ 705
            |..|.|||||:|::|||||.||:.|||||||.||||||||..:|.:|.|:||||||.|::|||||
Yeast   453 HCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQ 517

  Fly   706 QARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVM 770
            .:|:::|:|||||||||||||||||||.||||..|.||:|.|.|||.||..::.:||||..|.|:
Yeast   518 ASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVI 582

  Fly   771 CGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMN 835
            ||:...|.....|:...:..||:|||:.:.:.|..:..|:.|::|.|||...||||.:.|.|.:|
Yeast   583 CGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFIN 647

  Fly   836 SSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLI 900
            .|..:|.:.:||||||||::.|.|:|.|.||||...|:.:.:.|.:.|.||||:.||:||.|||:
Yeast   648 GSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLV 712

  Fly   901 NMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTK 965
            ..:||:|.|:.|||.|||||||||.|.|.|||.|.|..:::||:.:.||.::..:.|||||.|..
Yeast   713 KFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKH 777

  Fly   966 AQPFKGQFLQPENAPVPEKLNRVHNTYKSI---LENTLAGYCLPEPFNAQRLRDIIEKFMQSLRD 1027
            |.||:| .|....:||.|.....:. :||:   |||.|.||......||.     :::.::.||:
Yeast   778 ALPFEG-MLPDFGSPVIEGTKPAYK-FKSLVSTLENILKGYDNQVIMNAS-----LQQLIEVLRN 835

  Fly  1028 PSLPLLELQEVIASISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRA 1092
            |.||..|.:..|:::..|:|..:::::.:|:....|.    .|.||::|::.:||......:...
Yeast   836 PKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRR----GAVFPARQLSKLIDMAVKNPEYNP 896

  Fly  1093 DRDVFFLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHY--DKCVGLVREHNKD 1155
            |: :.....:.:..:..:|.||:.....:.....|.:||:||..|...:.  :..:..:|:.|..
Yeast   897 DK-LLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPK 960

  Fly  1156 DMQTVVNTIFSHSQVAKKNLLVTLLIDH---LWANEPGLTDELANTLSELTSLNRAEHSRVALRS 1217
            |:..|..|:.|||:|:.||.|:..::.|   |......::...:..|..:..|.....::|||::
Yeast   961 DLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQA 1025

  Fly  1218 RQVLIAAHQPAYELRHNQMESIFLSAV--DMYGHDFHPEN-------LQRLILSETSIFDILHDF 1273
            |::||....|:.:.|..|:|.|..|:|  ..||.. :|:.       |:.||.|...:||:|..|
Yeast  1026 REILIQGALPSVKERTEQIEHILKSSVVKVAYGSS-NPKRSEPDLNILKDLIDSNYVVFDVLLQF 1089

  Fly  1274 FYHSNRAVCNAALEVYVRRAYTSYELTCLQ-HLELSGGLPLVHFQFLLPTAHPNRLFSRMSSPDG 1337
            ..|.:..|..||.:||:||||.:|.:..:: |..::  :|:|.::|.||:| ....|..:.|..|
Yeast  1090 LTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVT--VPIVEWKFQLPSA-AFSTFPTVKSKMG 1151

  Fly  1338 LDQAAAES----LGNSF---VRTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVEA 1395
            :::|.:.|    :.||.   :|.|.:.|.|..:..    ||||             ::.||.:  
Yeast  1152 MNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDV----DEIL-------------SQSLEVI-- 1197

  Fly  1396 ADSISDSRHSTSIN----------VSLSDPVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMA 1450
                  .||.:|.|          .|||:......|:.|...:|  ..:.|.:||..:|      
Yeast  1198 ------PRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESE--EEILVRLREILDL------ 1248

  Fly  1451 QIFGNYCQEHNEELFQRRIRRITFA-ALKKRQFPKFFTFRARDKFTEDRIYRHLEPASAFHLELN 1514
                     :.:||....||||||. ..|...:||::||.. ..:.|:...||:|||.||.|||.
Yeast  1249 ---------NKQELINASIRRITFMFGFKDGSYPKYYTFNG-PNYNENETIRHIEPALAFQLELG 1303

  Fly  1515 RMKTYDLEALPTANQKMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEASFEYLQNEGERV 1579
            |:..::::.:.|.|:.:|:|...:|.|.    .|.|||.|.|||...:....:..|||.:|..|:
Yeast  1304 RLSNFNIKPIFTDNRNIHVYEAVSKTSP----LDKRFFTRGIIRTGHIRDDISIQEYLTSEANRL 1364

  Fly  1580 LLEAMDELEVAFSHPHAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGPRLWKLRVLQAEL 1644
            :.:.:|.|||.    ....:|.||||:||:....:.|..:|.:....:.|:|.||.:|||..||:
Yeast  1365 MSDILDNLEVT----DTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEI 1425

  Fly  1645 KMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPISTPYM 1709
            :::|:.........:|..|.|.|||.:...|||| .:...|...||:.| |.||:|..||:|||.
Yeast  1426 RIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTE-VKNAKGEWVFKSLG-KPGSMHLRPIATPYP 1488

  Fly  1710 TKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVLEGD 1774
            .|::||.||::|...|||||||.|::|||.:...|:.||     .|::..|...|..:.:..|..
Yeast  1489 VKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFS-----ADVKLTDDFFISNELIEDENG 1548

  Fly  1775 NLVEMQRLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQ 1839
            .|.|::|.||.|..||||::|.:.|||||.||:.:|:|||:|:.|||||.:||..|.|.::.||:
Yeast  1549 ELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARK 1613

  Fly  1840 LKVPRIYISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIE 1904
            ..:||||::.|||||||:|||:..:|::||.|...|||||:||||::|....:...:...::|.|
Yeast  1614 RGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTE 1678

  Fly  1905 D---EGEQRYKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLG 1966
            .   .||:|:.|..|||.:||||||.||.:|||||.||:||.:|.||.:||||::|||:|:||||
Yeast  1679 RTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLG 1743

  Fly  1967 QRVIQIDNSHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLS 2031
            ||.||::...|||||..|:||:|||:||.||.||||||||:||||:|.|...||.||..|::|:|
Yeast  1744 QRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMS 1808

  Fly  2032 YIPAYIGCDLPIVLPNDRIERPVDFMPTK-SPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIM 2095
            |:||.....:||:...|..:|||||.||. ..||.|||:.||   ...:.:|.|.||:.|:.|.:
Yeast  1809 YVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGR---ETESGFEYGLFDKGSFFETL 1870

  Fly  2096 ASWAKTVVTGRARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQA 2160
            :.|||.||.|||||||:|:|||.|||||||..:||||||.:|....:|:.||||:|:|::|||||
Yeast  1871 SGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQA 1935

  Fly  2161 IKDFGR-EELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAW 2224
            |.||.. |:||:::.|||||||||.:||:.:::|:|::|||.|.:||:|::||:||..|||||:|
Yeast  1936 INDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSW 2000

  Fly  2225 AVLDSLINPRYMETYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASG 2289
            .|:|..||...||.|||..||.|||||:|:|.||::.:.|:.|::|||.....|:.:|      .
Yeast  2001 VVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQL------S 2059

  Fly  2290 DKVRAAQVDEKIKARIA----VLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYW 2350
            :|..|.:|.::|..::|    .|:.:|..:::.||||||...||:.|..||:.:.|.::||:.:|
Yeast  2060 NKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFW 2124

  Fly  2351 RLRRLLLEDAYIKKILRAQDNLSVGQAKQM-----LRRWL---VEEKGATEAYLWDKNEEMVSWY 2407
            ||||.|.|:..||::     :..||:|.::     :|.|.   |:.         :.:.::.:|.
Yeast  2125 RLRRRLNEEYLIKRL-----SHQVGEASRLEKIARIRSWYPASVDH---------EDDRQVATWI 2175

  Fly  2408 EEQINAESIVSRNVNSVRRDAIISTISKMLEDCPDVALDAVVGLCQGLTPVNRGVVVRTL 2467
            ||....   :...:..::.::....::|.:....|.|:|.:..:.:.|:..::..:::||
Yeast  2176 EENYKT---LDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTL 2232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACCNP_610342.1 AccC 260..757 CDD:223516 329/509 (65%)
CPSase_L_chain 260..379 CDD:278706 82/120 (68%)
ATP-grasp_4 384..607 CDD:302634 146/226 (65%)
Biotin_carb_C 644..751 CDD:280880 75/106 (71%)
biotinyl_domain 891..952 CDD:133459 34/60 (57%)
ACC_central 956..1700 CDD:285519 224/779 (29%)
Carboxyl_trans 1800..2344 CDD:279390 281/552 (51%)
ACC1NP_014413.1 AccC 59..570 CDD:223516 329/510 (65%)
AccB 622..769 CDD:223585 71/146 (49%)
ACC_central 768..1479 CDD:400565 224/779 (29%)
Carboxyl_trans 1574..2118 CDD:395825 281/552 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 589 1.000 Domainoid score I26
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31015
Inparanoid 1 1.050 1732 1.000 Inparanoid score I5
Isobase 1 0.950 - 0 Normalized mean entropy S894
OMA 1 1.010 - - QHG53830
OrthoFinder 1 1.000 - - FOG0001818
OrthoInspector 1 1.000 - - otm46952
orthoMCL 1 0.900 - - OOG6_101052
Panther 1 1.100 - - LDO PTHR45728
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11
SonicParanoid 1 1.000 - - X1180
TreeFam 00.000 Not matched by this tool.
1312.950

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