DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and HFA1

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	NP_013934.1	Gene:	HFA1 / 855247	SGDID:	S000004820	Length:	2123	Species:	Saccharomyces cerevisiae

Alignment Length:	2235	Identity:	898/2235 - (40%)
Similarity:	1337/2235 - (59%)	Gaps:	203/2235 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 MRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIAL 340
            |||||:||||.|.:|:.|:||||.||:||.||:|||:|||.||.||||:|||||||::||:|:|.
Yeast     1 MRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQVPGGTNNNNYANIDLILDVAE 65

  Fly   341 RTQVQAVWAGWGHASENPKLPELL--HKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWS 403
            :|.|.|||||||||||||.|||||  .:..::|:|||.|||.:||||::|:||||:|:||.:|||
Yeast    66 QTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWS 130

  Fly   404 GSDLKAQYSGKK---IKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGGGKGIRRVDTTE 465
            ||.:...:...|   :.:..:::.|||.::.|..|.....||||||||||||||||||||||..:
Yeast   131 GSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNED 195

  Fly   466 EFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPA 530
            :|..|:||...|.||||:||||:...||||||||||||||..|:||||||||||||||||||||.
Yeast   196 DFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPV 260

  Fly   531 IVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDP-EGRYFFLELNPRLQVEHPCTEMVADVNL 594
            .:.:||.|:.||:||:||.::|||||||||||||.| :.:::|||||||||||||.|||::.|||
Yeast   261 TITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNL 325

  Fly   595 PAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSENPDEGFKPS 659
            ||.||||.||||::.:.|||.|||..|.|:|.|||:| ..:|.|.||.|:.|||||:|:||||||
Yeast   326 PATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKN-LKRPSPKGHCISCRITSEDPNEGFKPS 389

  Fly   660 SGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGDF 724
            :|.:.|||||||.||||||||..:|.:|.|:||||||.|:.|.:||.|::|:|:|||:.||||:|
Yeast   390 TGKIHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEF 454

  Fly   725 RTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSE-KPDILLGVMCGS---LHIADRQITESF 785
            :|.:||||.||||..|..|:|.|.|||.||.:.:.|: |.|..|.::||:   .::...::...:
Yeast   455 KTPIEYLIELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKAYVFTEKVRNKY 519

  Fly   786 SSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGG 850
            ...   |.:||:...:.|.....|:.|.|..||....|:|....:.|.:|.|..|:.|.:||...
Yeast   520 LEL---LRRGQVPPKDFLKTKFPVDFIFDNNRYLFNVAQSSEEQFILSINKSQCEVNVQKLSSDC 581

  Fly   851 LLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVSKGQA 915
            ||||::|..:|.|.|:::...|:.|.:.|...|.|.:|:.:.||:.|||:..:|..|.||..||.
Yeast   582 LLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVISPTPGKLVKYLVRSGDHVFAGQQ 646

  Fly   916 YAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQF--LQP-- 976
            |||||:|||.|.|.::..|.:..:|:||::::||.::..|.||.||...::..::|:.  |.|
Yeast   647 YAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDVIAKLTLDSPSKANESSLYRGELPVLGPPL 711

  Fly   977 -ENAPVPEKLNRVHNTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIA 1040
             |.:....||..:.|.    |||.|.||     .....:...:::.::.|||..||..|....|:
Yeast   712 IEGSRPNHKLRVLINR----LENILNGY-----HENSGIETTLKELIKILRDGRLPYSEWDSQIS 767

  Fly  1041 SISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIV 1105
            ::..|:|..:.:.:        .|:......||::::..::..:   |::..:..|.::..|.::
Yeast   768 TVRNRLPRQLNEGL--------GNLVKKSVSFPAKELHKLMKRY---LEENTNDHVVYVALQPLL 821

  Fly  1106 QLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYG--HYDKCVGLVREHNKDDMQTVVNTIFSHS 1168
            ::.:||..|:.........:|:::||.||..|:..  |.::.:..:|..:..:::.::....||:
Yeast   822 KISERYSEGLANHECEIFLKLIKKYYAVEKIFENHDIHEERNLLNLRRKDLTNLKKILCISLSHA 886

  Fly  1169 QVAKKNLLVTLLIDHLWANEPGLTDELANTLS------ELTSLNRAEHSRVALRSRQVLIAAHQP 1227
            .|..||.|||.::...   ||...|....:|.      :|.||.......||:::|.||:....|
Yeast   887 NVVAKNKLVTAILHEY---EPLCQDSSKMSLKFRAVIHDLASLESKWAKEVAVKARSVLLRGIFP 948

  Fly  1228 AYELRHNQMESIF-LSAVDMYGHDFHPENLQ-------RLILSETSIFDILHDFFYHSNRAVCNA 1284
            ..:.|...::::. |...|....:.|..|:.       .||.|.......|..||.|.:.|:.:.
Yeast   949 PIKKRKEHIKTLLQLHIKDTGAENIHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSI 1013

  Fly  1285 ALEVYVRRAYTSYELTCLQHLELSGGLP--LVHFQF------LLPTAHPNRLFSRMSSPDGLDQA 1341
            |.|:|.|.||.:|:   |:.:::..|.|  |:.:||      |:.:...:..|:::|.|   ...
Yeast  1014 ASEIYARYAYGNYQ---LKSIKIHKGAPDLLMSWQFSSLRNYLVNSDGESDEFTKLSKP---PST 1072

  Fly  1342 AAESLGNSFVRTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVE-AADSISDSRHS 1405
            :.:|..|||                               ..:||.:.||::| ..|.:.:..|.
Yeast  1073 SGKSSANSF-------------------------------GLLVNMRALESLEKTLDEVYEQIHI 1106

  Fly  1406 TSINVSLSDPVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIR 1470
                     |..|.::.|.:..   ::|:| .:|...|.|.::..:|   ...|:...|.:.::.
Yeast  1107 ---------PEERLSSGENSLI---VNILS-PIRYRSENDLIKTLKI---KLHENERGLSKLKVN 1155

  Fly  1471 RITFAALKKRQFP--KFFTFRARDKFTEDRI--YRHLEPASAFHLELNRMKTYDLEALPTANQKM 1531
            |||||.:.... |  ||::|   |..|.|.|  .|:::|:....|||.:|..|.:.:|||.:..:
Yeast  1156 RITFAFIAANA-PAVKFYSF---DGTTYDEISQIRNMDPSYEAPLELGKMSNYKIRSLPTYDSSI 1216

  Fly  1532 HLYLGKAKVSKGQEVTDYRFFIRSIIR---HSDLITKEASFEYLQNEGERVLLEAMDELEVAFSH 1593
            .::.|.:|.:.    .|.|||:|.||.   ::|..|.|.:.:...|.....:||.:..::::
Yeast  1217 RIFEGISKFTP----LDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVVYMLEHLGAVDIS--- 1274

  Fly  1594 PHAKRTDCNHIFLNFVPTVIMDPA-KIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQSPQSPTQ 1657
                .:|.|||||:| .||:..|. ::||.|:.::..:..||::.|:...|:.:.:.........
Yeast  1275 ----NSDLNHIFLSF-NTVLNIPVHRLEEIVSTILKTHETRLFQERITDVEICISVECLETKKPA 1334

  Fly  1658 AVRLCIANDSGYFLDISMYTEQTEPETGII-----KFKAYGEKQGSLHGHPISTPYMTKDFLQQK 1717
            .:||.|:|.|||.:.|..|.|:......:|     :...|.:|.       :|.||..||:||.|
Yeast  1335 PLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKS-------LSLPYSVKDWLQPK 1392

  Fly  1718 RFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVLEGDNLVEMQRL 1782
            |::||..|||||||.|.:|.|...:.|:.:.......|      ......||:.:..||:::.|.
Yeast  1393 RYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLND------SFFSWVELIEQNGNLIKVNRE 1451

  Fly  1783 PGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYI 1847
            ||.||.||||:.|::.|||||.||.:|||:||:||.|||||.:||:.|.:.:..||:..:||||:
Yeast  1452 PGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERGIPRIYL 1516

  Fly  1848 SVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDE---GEQ 1909
            :.||||::|:|||:..:|::||.||.:|.|||:||||:.:|...:.:.....::::|.:   ||:
Yeast  1517 AANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLYLAPKDMQLLKDSGKGNSVVVEHKMVYGEE 1581

  Fly  1910 RYKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDN 1974
            ||.|..|:|.::|||||.|:.:|||||.||:||.:|.||..||||::|||||:||||||.||:::
Yeast  1582 RYIIKAIVGFEEGLGVECLQGSGLIAGATSKAYRDIFTITAVTCRSVGIGSYLVRLGQRTIQVED 1646

  Fly  1975 SHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGC 2039
            ..|||||.:|:||:||..:|.||.|:||||||:.||:.|.|.:.|:..:..|:.||||:||....
Yeast  1647 KPIILTGASAINKVLGTDIYTSNLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDM 1711

  Fly  2040 DLPIVLPNDRIERPVDFMPTKS-PYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVV 2103
            ..|::...||.:|.|||.|.|. ||:.||::.|:.:  :.|::::|.||:||:.|.::.|||.|:
Yeast  1712 SPPLLETMDRWDRDVDFKPAKQVPYEARWLIEGKWD--SNNNFQSGLFDKDSFFETLSGWAKGVI 1774

  Fly  2104 TGRARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFG-RE 2167
            .|||||||:|||||||||:|:|..:|||||||||...::::|||||||:|::||||.|.||. .|
Yeast  1775 VGRARLGGIPVGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGE 1839

  Fly  2168 ELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLIN 2232
            :||||:.|||||||||.:|||.:::|:|::|||.|.:||:|:|||:||..|||||:|.|:|..||
Yeast  1840 QLPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVIDPTIN 1904

  Fly  2233 PRYMETYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQV 2297
            |..||.|||.|:|||||||:|:|.|||:::.:::|:.|||.|...|::.|.|...|.:|..  .:
Yeast  1905 PEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKKLSLEKQN--DL 1967

  Fly  2298 DEKIKARIAVLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYI 2362
            .:::|.|...|:.:|:.:::.||||||...|||.|..|...:.|:.|||:|||||||.|.|...|
Yeast  1968 TKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRRFLYWRLRRRLNEGQVI 2032

  Fly  2363 KKILRAQ-DNLSVGQAKQMLRRWLVEEKGATEAYLWDKNEEMVSWYEE-QINAESIV-------- 2417
            |::.:.. ||.:..:...:|:  :|:                 |||.: .:|.:..|
Yeast  2033 KRLQKKTCDNKTKMKYDDLLK--IVQ-----------------SWYNDLDVNDDRAVVEFIERNS 2078

  Fly  2418 ---SRNVNSVRRDAIISTISKMLED 2439
               .:|:.......:|..:.|..||
Yeast  2079 KKIDKNIEEFEISLLIDELKKKFED 2103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	305/486 (63%)
		CPSase_L_chain	260..379	CDD:278706	70/104 (67%)
		ATP-grasp_4	384..607	CDD:302634	142/226 (63%)
		Biotin_carb_C	644..751	CDD:280880	66/106 (62%)
		biotinyl_domain	891..952	CDD:133459	27/60 (45%)
		ACC_central	956..1700	CDD:285519	184/786 (23%)
		Carboxyl_trans	1800..2344	CDD:279390	277/548 (51%)
HFA1	NP_013934.1	AccC	1..488	CDD:223516	305/487 (63%)
		CPSase_L_chain	1..106	CDD:278706	70/104 (67%)
		ATP-grasp_4	111..338	CDD:302634	142/226 (63%)
		Biotin_carb_C	375..481	CDD:280880	66/105 (63%)
		AccB	505..688	CDD:223585	60/185 (32%)
		biotinyl_domain	621..686	CDD:133459	27/64 (42%)
		ACC_central	687..1371	CDD:285519	182/775 (23%)
		Carboxyl_trans	1469..2026	CDD:279390	287/560 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	589	1.000	Domainoid score	I26
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1732	1.000	Inparanoid score	I5
Isobase	1	0.950	-	0	Normalized mean entropy	S894
OMA	1	1.010	-	-		QHG53830
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		otm46952
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	O	PTHR45728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11
SonicParanoid	1	1.000	-	-		X1180
TreeFam	0	0.000	Not matched by this tool.
	12	11.950