DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and ACC2

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	NP_174850.4	Gene:	ACC2 / 840522	AraportID:	AT1G36180	Length:	2355	Species:	Arabidopsis thaliana

Alignment Length:	2410	Identity:	909/2410 - (37%)
Similarity:	1343/2410 - (55%)	Gaps:	298/2410 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 EFPL----------KMQNDVRQNGDISERRKRLRPSMSRGTGLGQDRHQD--RDFHIATTEEFVK 252
            :|||          .::|||.:    :||...|......|.|.....|.|  ...::|...||.|
plant    71 QFPLFCFLNPDPISFLENDVSE----AERTVVLPDGSVNGAGSVNGYHSDVVPGRNVAEVNEFCK 131

  Fly   253 RFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHY 317
            ..||.|.|:.:|:|.||:||||.:||:|.||||.|.:|:|::.|.|.||||::.|||:|::||.:
plant   132 ALGGKRPIHSILVATNGMAAVKFIRSVRTWAYETFGSEKAVKLVAMATPEDMRINAEHIRIADQF 196

  Fly   318 VPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWAL 382
            |.||||:||||||||:|||::|..|:|.|||.|||||||||:||:.|.::|::|||||..:|.||
plant   197 VEVPGGTNNNNYANVQLIVEMAEVTRVDAVWPGWGHASENPELPDALKEKGIIFLGPPADSMIAL 261

  Fly   383 GDKVASSIVAQTAEIPTLPWSGSDLKAQYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMI 447
            |||:.||::||.|::||||||||.:|.......:.:..|::.:.||...|:.:|:...:|:|.||
plant   262 GDKIGSSLIAQAADVPTLPWSGSHVKIPPGRSLVTVPEEIYKKACVYTTEEAIASCQVVGYPAMI 326

  Fly   448 KASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFG 512
            |||.||||||||:|...:|...||:|||.||||||||:||:|..:||||.|||.|||||..:|..
plant   327 KASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEAQLLCDQYGNVAALHS 391

  Fly   513 RDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPE-GRYFFLELN 576
            ||||:||||||||||.|..||..|..:.:|:||.||||.|.||.|.||||||..: |.|:|||||
plant   392 RDCSVQRRHQKIIEEGPITVAPQETIKKLEQAARRLAKSVNYVGAATVEYLYSMDTGEYYFLELN 456

  Fly   577 PRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWG-----------SSVIDFE 630
            ||||||||.||.:|:|||||||:.:||||||:::.:||..||....|           :|..||:
plant   457 PRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMEHGGGYDSWRKTSVVASPFDFD 521

  Fly   631 NPPNKPRPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFG 695
            ...:. ||.||.:|.|:|||:||:||||:||.:|||:|:|..|:|.||||.:.||:|||:|||||
plant   522 EAESL-RPKGHCVAVRVTSEDPDDGFKPTSGEIQELSFKSKPNMWSYFSVKSGGGIHEFSDSQFG 585

  Fly   696 HCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQS 760
            |.|::||:|..|..|:|:||||:.||||.||.|:|.|.||..:.:.:|.|.|.|||:.||.||::
plant   586 HVFAFGESRSVAIANMVLALKEIQIRGDIRTNVDYTIDLLHASDYRENKIHTGWLDSRIAMRVRA 650

  Fly   761 EKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKS 825
            |:|...|.|:.|:|:.|....:...|.:...||||||...:.......|.|..:|.:|.:...:.
plant   651 ERPPWYLSVVGGALYKASTTSSAVVSDYVGYLEKGQIPPKHISLVHSQVSLNIEGSKYTIDVVRG 715

  Fly   826 GANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSL 890
            |:.:|.|.|::|....|:|.|.|||||:.|:|.|:..|.|||....|::|..:||:.:.::|||.
plant   716 GSGTYRLRMSNSEVVAEIHTLRDGGLLMQLDGKSHVIYAKEEATGTRLLIDGRTCLLQNDHDPSK 780

  Fly   891 LRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHL 955
            |.:.:..||:..:|.|.:.:.....|||:|||||.|.|.|..:|.:.|....|..:.||.|:..|
plant   781 LMAETPCKLLRYLVSDNSSIDTDTPYAEVEVMKMCMPLISPASGVIHFKLSEGQAMQAGELIAKL 845

  Fly   956 ELDDPSLVTKAQPFKGQFLQPENAPVPEKLN-RVHNTYKSILENT---LAGYCLPEPFNAQRLRD 1016
            :|||||.|.||:||:|.|   ....:|..:: :||....:.|...   ||||       ..::.:
plant   846 DLDDPSAVRKAKPFRGSF---PRLGLPTAISGKVHQRCAATLNAARMILAGY-------DHKVDE 900

  Fly  1017 IIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKKIRKLMTLYERNI-----TSVLAQFPSQQ 1076
            :::..:..|..|.||.|:.||..|.::.|:|    |.:|.::.|..:..     ||:...||::.
plant   901 VLQDLLNCLDSPELPFLQWQECFAVLATRLP----KDLRNMLELKYKEFEIISKTSLTPDFPAKL 961

  Fly  1077 IASVIDSHAATLQKRADRDVFFLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGH 1141
            :..::::|.::..:: :|.......:.::.||:.|..|.....:..||.|..:|..||..|....
plant   962 LKGILEAHLSSCDEK-ERGSLERLIEPLMSLVKSYEGGRESHARLIVHSLFEEYLSVEELFNDNM 1025

  Fly  1142 YDKCVGLVREHNKDDMQTVVNTIFSHSQVAKKNLLVTLLIDHLWANEPGLTDELANTLSELTSLN 1206
            ....:..:|:..|.|...:|:.:.||..:..||.||..|::.|....|....|   .|...::||
plant  1026 LADVIERMRQQYKKDRLKIVDIVLSHQGIIHKNKLVLRLMEQLVYPNPAAYRE---KLIRFSALN 1087

  Fly  1207 RAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAVDMY---GHDFH--------PENLQRLI 1260
            ...:|::||::.|:|....:.  |||.|...|  ||.::|:   |.:..        .|.::.|:
plant  1088 HTNYSQLALKASQLLEQTKRS--ELRSNIARS--LSELEMFTEAGENMDTPKRKSAISETMENLV 1148

  Fly  1261 LSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELTCLQHLELSGGLPLVHFQFLLPTAHP 1325
            .|..::.|.|...|.||:..:....:|.|:.|.|..|
plant  1149 SSSLAVEDALVGLFDHSDHTLQRRVVETYIHRLYQPY---------------------------- 1185

  Fly  1326 NRLFSRMSSPDGLDQAAAESLGNSFVRTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAK-- 1388
                           ...||:...:.::|.||:::..||||..:....|   ..:|...:.||
plant  1186 ---------------VVKESVRMQWHQSGVIASWEFLEHFERKNTGPDD---HEISEKGIVAKSS 1232

  Fly  1389 --------VLEAVEAADSISDSRHSTSINVSLSDPVTRANAAEEAK---STEPIHIVSVAV---- 1438
                    ::::::...||        ||.||.:  |..:..|.|:   |...:||..|.:
plant  1233 KRKRGTMVIIKSLQFLPSI--------INASLRE--TNHSHCEYARAPLSGNMMHIAVVGINNQM 1287

  Fly  1439 ---RETGELDDLQ-----MAQIFGN---------------YCQEHNEELFQRRIRRITFAALKKR 1480
               :::|:.|..|     :|:|...               .|....:|  .|...|.:|..|.::
plant  1288 SLLQDSGDEDQTQERVNKLAKILKEEEVSLTLCSAGVGVISCIIQRDE--GRTPMRHSFHWLMEK 1350

  Fly  1481 QFPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTY-DLEALPTANQKMHLYLGKAKVSKGQ 1544
            |:           :.|:.:.||:||..:.:|||:::|.| :::..|:.:::.|:|
plant  1351 QY-----------YVEEPLLRHVEPPLSVYLELDKLKGYSNIQYSPSRDRQWHMY---------- 1394

  Fly  1545 EVTD-----YRFFIRSIIRHSDLITKEASFEYLQNEGE-------------------RVLLEAMD 1585
            .|||     .|.|:||::|.:.:     :..:|..:|:                   |.|:.||:
plant  1395 SVTDRPVPIKRMFLRSLVRQTTM-----NDGFLLQQGQDYQLSQTVLSMAFTSKCILRSLMNAME 1454

  Fly  1586 ELEVAFSHPHAKRTDCNHIFL-----NFVPTVIMDPAKIE--------------ESVTKMIMR-Y 1630
            |||:. :|..|.:.|..|:||     ..:..::..|.:.|              |..|:.|.| .
plant  1455 ELELN-AHNAAMKPDHAHMFLCILREQQIDDLVPYPRRFEVNAEDEETTVETILEEATQEIHRSV 1518

  Fly  1631 GPRLWKLRVLQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEK 1695
            |.|:..|.|.:.|:::.:..|..: ..|.|:.:||.:|....:.:|.|........:.:.:. .|
plant  1519 GVRMHALGVCEWEVRLWLVSSGLA-NGAWRVVVANVTGRTCTVHIYREVEATGRNSLIYHSI-TK 1581

  Fly  1696 QGSLHGHPISTPYMTKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPD 1760
            :|.|||..|:..|...:.|.:||..|:.:.|||.||.|..|....|.:|     |.....:|.|.
plant  1582 KGPLHGTLINGQYKPLNNLDRKRLAARRSNTTYCYDFPLAFETALELNW-----ASQHSGVRKPC 1641

  Fly  1761 K-ILIECKELVLE------GDNLVEMQRLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYL 1818
            | .||..||||..      |.:|:.::|..|.|:.|||||.:.::|||:|.||:::::|||:|:.
plant  1642 KNRLINVKELVFSNTEGSLGTSLIPVERPAGLNDIGMVAWILEMSTPEFPMGRKLLIVANDVTFK 1706

  Fly  1819 IGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLY 1883
            .||||.:||..|...::||...|:|.||::.|||||:|:||||||.||:.|.|...|...|:|:|
plant  1707 AGSFGPREDAFFLAVTELACTKKLPLIYLAANSGARLGVAEEVKACFKVGWSDEVSPGNDFQYIY 1771

  Fly  1884 LSTEDYAQVANLNSVRAILIE-DEGEQRYKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVT 1947
            ||:||||::.  :||.|..:: ..||.|:.|..|:||:||||||||..:|.|||..|:||.|..|
plant  1772 LSSEDYARIG--SSVIAHEVKLPSGETRWVIDTIVGKEDGLGVENLTGSGAIAGAYSRAYNETFT 1834

  Fly  1948 IAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVT 2012
            :..|:.|::|||:|:.|||.|.||..:..|||||::.|||||||:||:|:.||||.:||..|||.
plant  1835 LTFVSGRSVGIGAYLARLGMRCIQRLDQPIILTGFSTLNKLLGREVYSSHMQLGGPKIMGTNGVV 1899

  Fly  2013 HKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVLPNDRIERPVDFMPTKSPYDPRWMLGGRVNPVN 2077
            |.|.:.||:||..||:||||||||:|..||::.|.|..||.|:::|..| .|||..:.| :|. |
plant  1900 HLTVSDDLEGVSAILNWLSYIPAYVGGPLPVLAPLDPPERTVEYIPENS-CDPRAAIAG-IND-N 1961

  Fly  2078 ANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTL 2142
            ...|..|.||::|:.|.:..||:|||||||:|||:|:||:||||:||...:||||..|||..:.:
plant  1962 TGKWLGGIFDKNSFVETLEGWARTVVTGRAKLGGIPIGVVAVETQTVMHVIPADPGQLDSHERVV 2026

  Fly  2143 QQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKK 2207
            .||||||:|||:.|||||:.||.||:|||.:.|||||||||.:|::|.|::.|:.||:.||.|::
plant  2027 PQAGQVWFPDSAAKTAQALMDFNREQLPLFIIANWRGFSGGQRDLFEGILQAGSAIVENLRTYRQ 2091

  Fly  2208 PVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLD 2272
            ||.:|:|...|||||||.|:||.||..|:|.|||..|||.||||||::|||::.|:|::.:.|||
plant  2092 PVFVYIPMMGELRGGAWVVVDSQINSDYIEMYADETARGNVLEPEGMIEIKFRRKELLECMGRLD 2156

  Fly  2273 PTTIALKKELDEANASGDKVRAAQVDEKIKARIAVLMHVYHTVAVHFADLHDTPERMLEKECISE 2337
            .|.|.||..:.:|..:........:.::||.|...|:.||..:|..||:||||..||..|..|..
plant  2157 QTLINLKANIQDAKRNKAYANIELLQKQIKTREKQLLPVYTQIATKFAELHDTSMRMAAKGVIKS 2221

  Fly  2338 IVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQ-DNLSVGQAKQMLRRWLVEE---KGATEAYLWD 2398
            :|.|..||.:.|.:|.|.:.|.:.::.|.:|. |.||...|..:::.|..:.   ||..||  |.
plant  2222 VVEWSGSRSFFYKKLYRRIAESSLVRNIRKASGDILSYKSAMGLIQDWFRKSEIAKGKEEA--WT 2284

  Fly  2399 KNEEMVSWYEEQINAESIVS-------------------------------RNVNSVRRDAIIST 2432
            .::...:|.:...|.|..:|                               ..|:..||:.::..
plant  2285 DDQLFFTWKDNVSNYEQKLSELRTQKLLNQLAEIGNSSDLQALPQGLANLLNKVDLSRREELVDA 2349

  Fly  2433 ISKML 2437
            |.|:|
plant  2350 IRKVL 2354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	285/508 (56%)
		CPSase_L_chain	260..379	CDD:278706	71/118 (60%)
		ATP-grasp_4	384..607	CDD:302634	131/223 (59%)
		Biotin_carb_C	644..751	CDD:280880	61/106 (58%)
		biotinyl_domain	891..952	CDD:133459	21/60 (35%)
		ACC_central	956..1700	CDD:285519	189/848 (22%)
		Carboxyl_trans	1800..2344	CDD:279390	278/544 (51%)
ACC2	NP_174850.4	Peptidases_S8_S53	<9..>38	CDD:299169
		CPSase_L_chain	139..258	CDD:278706	71/118 (60%)
		AccC	142..647	CDD:223516	284/505 (56%)
		ATP-grasp_4	263..487	CDD:302634	131/223 (59%)
		Biotin_carb_C	534..641	CDD:280880	61/106 (58%)
		biotinyl_domain	781..845	CDD:133459	22/63 (35%)
		ACC_central	846..1586	CDD:285519	189/848 (22%)
		Carboxyl_trans	1688..2240	CDD:279390	283/556 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	561	1.000	Domainoid score	I46
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31015
Inparanoid	1	1.050	1352	1.000	Inparanoid score	I12
OMA	1	1.010	-	-		QHG53830
OrthoDB	1	1.010	-	-		D156081at2759
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		otm3180
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	O	PTHR45728
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1180
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980