DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and ACC1

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	NP_001185143.1	Gene:	ACC1 / 840521	AraportID:	AT1G36160	Length:	2254	Species:	Arabidopsis thaliana

Alignment Length:	2312	Identity:	897/2312 - (38%)
Similarity:	1332/2312 - (57%)	Gaps:	197/2312 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 IATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANA 308
            ::..:||.|...|.|.|:.:||||||:||||.:||:|.||||.|..|:||..|.|.||||::.||
plant    21 VSQVDEFCKALRGKRPIHSILIANNGMAAVKFIRSVRTWAYETFGTEKAILLVGMATPEDMRINA 85

  Fly   309 EYIKMADHYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLG 373
            |:|::||.:|.||||:||||||||:|||::|..|:|.|||.|||||||||:||:.|..:|::|||
plant    86 EHIRIADQFVEVPGGTNNNNYANVQLIVEMAEVTRVDAVWPGWGHASENPELPDALDAKGIIFLG 150

  Fly   374 PPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQYSGKKIKISSELFARGCVTNVEQGLAAV 438
            ||..:|.|||||:.||::||.|::||||||||.:|...:...:.|..|::.:.||...|:.:|:.
plant   151 PPASSMAALGDKIGSSLIAQAADVPTLPWSGSHVKIPPNSNLVTIPEEIYRQACVYTTEEAIASC 215

  Fly   439 NKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQ 503
            ..:|:|.|||||.||||||||:|...:|...||:|||.||||||||:||:|..:||||||||.|:
plant   216 QVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEVQLLCDK 280

  Fly   504 YGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPE- 567
            :||..:|..||||:||||||||||.|..||.||..:.:|:||.||||.|.||.|.||||||..:
plant   281 HGNVSALHSRDCSVQRRHQKIIEEGPITVAPPETVKKLEQAARRLAKSVNYVGAATVEYLYSMDT 345

  Fly   568 GRYFFLELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWG-------SS 625
            |.|:|||||||||||||.||.:|::||||||:.:||||||:::.:||..||....|       :|
plant   346 GEYYFLELNPRLQVEHPVTEWIAEINLPAAQVAVGMGIPLWQIPEIRRFYGIEHGGGYDSWRKTS 410

  Fly   626 VIDFENPPNKP---RPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLH 687
            |:.|....:|.   ||.||.:|.|:|||:||:||||:||.||||:|:|..|||.||||.:.||:|
plant   411 VVAFPFDFDKAQSIRPKGHCVAVRVTSEDPDDGFKPTSGRVQELSFKSKPNVWAYFSVKSGGGIH 475

  Fly   688 EFADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDA 752
            ||:||||||.|::||:|..|..|:|:.|||:.|||:.||.|:|.|.||..:.:.||.|.|.|||:
plant   476 EFSDSQFGHVFAFGESRALAIANMVLGLKEIQIRGEIRTNVDYTIDLLHASDYRDNKIHTGWLDS 540

  Fly   753 LIAERVQSEKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIR 817
            .||.||::|:|...|.|:.|:|:.|........|.:...||||||...:.......|.|..:|.:
plant   541 RIAMRVRAERPPWYLSVVGGALYKASATSAAVVSDYVGYLEKGQIPPKHISLVHSQVSLNIEGSK 605

  Fly   818 YKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVF 882
            |.:...:.|:.:|.|.||.|....|:|.|.|||||:.|:|.|:..|.:||....|::|..:||:.
plant   606 YTIDVVRGGSGTYRLRMNKSEVVAEIHTLRDGGLLMQLDGKSHVIYAEEEAAGTRLLIDGRTCLL 670

  Fly   883 EKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLD 947
            :.::|||.|.:.:..||:..::.|.:::.....|||:|||||.|.|.|..:|.:.|....|..:.
plant   671 QNDHDPSKLMAETPCKLMRYLISDNSNIDADTPYAEVEVMKMCMPLLSPASGVIHFKMSEGQAMQ 735

  Fly   948 AGSLLGHLELDDPSLVTKAQPFKGQFLQPENAPVPEKLN-RVHNTYKSILENT---LAGYCLPEP 1008
            ||.|:.:|:|||||.|.||:||.|.|   ....:|..:: |||....:.|...   ||||
plant   736 AGELIANLDLDDPSAVRKAEPFHGSF---PRLGLPTAISGRVHQRCAATLNAARMILAGY----- 792

  Fly  1009 FNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPIS----VEKKIRKLMTLYERNITSVL 1069
              ..::.::::..:..|..|.||.|:.||..|.::.|:|.:    :|.|.|:..::...::|:
plant   793 --EHKVDEVVQDLLNCLDSPELPFLQWQECFAVLATRLPKNLRNMLESKYREFESISRNSLTT-- 853

  Fly  1070 AQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVE 1134
             .||::.:..::::|.::..:: :|.......:.::.|.:.|..|.....:..||.|..:|..||
plant   854 -DFPAKLLKGILEAHLSSCDEK-ERGALERLIEPLMSLAKSYEGGRESHARVIVHSLFEEYLSVE 916

  Fly  1135 SQFQYGHYDKCVGLVREHNKDDMQTVVNTIFSHSQVAKKNLLVTLLIDHL-WANEPGLTDELANT 1198
            ..|........:..:|:..|.|:..:|:.:.||..:..||.||..|::.| :.|.....|:|.
plant   917 ELFNDNMLADVIERMRQLYKKDLLKIVDIVLSHQGIKNKNKLVLRLMEQLVYPNPAAYRDKLI-- 979

  Fly  1199 LSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAVDMYGHDFH----------- 1252
              ..::||...:|.:||::.|:|  ......|||.|...|  ||.::|:..|..
plant   980 --RFSTLNHTNYSELALKASQLL--EQTKLSELRSNIARS--LSELEMFTEDGENMDTPKRKSAI 1038

  Fly  1253 PENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELTCLQHLELSGGLPLVHFQ 1317
            .|.::.|:.:..::.|.|...|.||:..:....:|.|:||.|..|.:.....::......|..::
plant  1039 NERIEDLVSASLAVEDALVGLFDHSDHTLQRRVVETYIRRLYQPYVVKDSVRMQWHRSGLLASWE 1103

  Fly  1318 FLLPTAHPNRLFSRMSSPDGLDQAAAESLGNSFVRTGAIAAFDSFEHFEMYSDEILDLLEDFVSP 1382
            ||  ..|..|....:..||..::...|.  .|..:.||:....|           |..|...:|.
plant  1104 FL--EEHMERKNIGLDDPDTSEKGLVEK--RSKRKWGAMVIIKS-----------LQFLPSIISA 1153

  Fly  1383 AMVNAKVLEAVEAADSISDSRHSTSINVSLSDPVT-RANAAEEAKSTEPIHIVSVAVRETGELDD 1446
            |:...|..:...|...:|.:....:| |.:::.:: ..::.:|.::.|.::.::..::|......
plant  1154 ALRETKHNDYETAGAPLSGNMMHIAI-VGINNQMSLLQDSGDEDQAQERVNKLAKILKEEEVSSS 1217

  Fly  1447 LQMAQIFGNYCQEHNEELFQRRIRRITFAALKKRQFPKFFTFRARDKFTEDRIYRHLEPASAFHL 1511
            |..|.:....|....:|  .|...|.:|....::|:           :.|:.:.|||||..:.:|
plant  1218 LCSAGVGVISCIIQRDE--GRTPMRHSFHWSLEKQY-----------YVEEPLLRHLEPPLSIYL 1269

  Fly  1512 ELNRMKTY-DLEALPTANQKMHLYLGKAKVSKGQEVTD-----YRFFIRSIIRHSDLITKEASFE 1570
            ||:::|.| :::..|:.:::.|||          .|||     .|.|:||::|.:   |....|.
plant  1270 ELDKLKGYSNIQYTPSRDRQWHLY----------TVTDKPVPIKRMFLRSLVRQA---TMNDGFI 1321

  Fly  1571 YLQNEGE-----------------RVLLEAMDELEVAFSHPHAKRTDCNHIFLNFV--------- 1609
            ..|.:.:                 |.|::||:|||:. :|..|.:.|..|:||..:
plant  1322 LQQGQDKQLSQTLISMAFTSKCVLRSLMDAMEELELN-AHNAAMKPDHAHMFLCILREQQIDDLV 1385

  Fly  1610 --PTVIMDPAKIEESVTKMIMR---------YGPRLWKLRVLQAELKMVIRQSPQSPTQAVRLCI 1663
              |..:...|:.||:..:||:.         .|.|:.:|.|.:.|:::.:..|..: ..|.|:.:
plant  1386 PFPRRVEVNAEDEETTVEMILEEAAREIHRSVGVRMHRLGVCEWEVRLWLVSSGLA-CGAWRVVV 1449

  Fly  1664 ANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQKRFQAQSNGTTY 1728
            ||.:|....:.:|.|...|....:.:.:. .|:|.||..|||..|....:|.::|..|:.:.|||
plant  1450 ANVTGRTCTVHIYREVETPGRNSLIYHSI-TKKGPLHETPISDQYKPLGYLDRQRLAARRSNTTY 1513

  Fly  1729 VYDVPDMFRQMTERHWREFSKARPTVDIRTPDK-ILIECKELVL------EGDNLVEMQRLPGEN 1786
            .||.|..|....|..|     |.....::.|.| .||..||||.      .|.:|..::|.||.|
plant  1514 CYDFPLAFGTALELLW-----ASQHPGVKKPYKDTLINVKELVFSKPEGSSGTSLDLVERPPGLN 1573

  Fly  1787 NCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNS 1851
            :.|||||.:.::|||:|.||:::|||||:|:..||||.:||..|...::||...|:|.||::.||
plant  1574 DFGMVAWCLDMSTPEFPMGRKLLVIANDVTFKAGSFGPREDAFFLAVTELACAKKLPLIYLAANS 1638

  Fly  1852 GARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIE-DEGEQRYKITD 1915
            |||:|:||||||.||:.|.|...|:.||:|:|||.||:.::.  :||.|..:: ..||.|:.|..
plant  1639 GARLGVAEEVKACFKVGWSDEISPENGFQYIYLSPEDHERIG--SSVIAHEVKLSSGETRWVIDT 1701

  Fly  1916 IIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILT 1980
            |:||:||:|||||..:|.|||..|:||.|..|:..|:.||:|||:|:.|||.|.||..:..||||
plant  1702 IVGKEDGIGVENLTGSGAIAGAYSKAYNETFTLTFVSGRTVGIGAYLARLGMRCIQRLDQPIILT 1766

  Fly  1981 GYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVL 2045
            |::.|||||||:||:|:.||||.:||..|||.|.|.:.||:||..||:||||||||:|..||::.
plant  1767 GFSTLNKLLGREVYSSHMQLGGPKIMGTNGVVHLTVSDDLEGVSAILNWLSYIPAYVGGPLPVLA 1831

  Fly  2046 PNDRIERPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLG 2110
            |.|..||.|:::|..| .|||..:.|..:  |...|..|.||::|:.|.:..||:|||||||:||
plant  1832 PLDPPERIVEYVPENS-CDPRAAIAGVKD--NTGKWLGGIFDKNSFIETLEGWARTVVTGRAKLG 1893

  Fly  2111 GVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFA 2175
            |:||||:||||:||...:||||..|||..:.:.||||||:|||:.|||||:.||.||||||.:.|
plant  1894 GIPVGVVAVETQTVMQIIPADPGQLDSHERVVPQAGQVWFPDSAAKTAQALMDFNREELPLFILA 1958

  Fly  2176 NWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYA 2240
            ||||||||.:|::|.|::.|:.||:.||.|::||.:|:|...|||||||.|:||.||..|:|.||
plant  1959 NWRGFSGGQRDLFEGILQAGSTIVENLRTYRQPVFVYIPMMGELRGGAWVVVDSQINSDYVEMYA 2023

  Fly  2241 DPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARI 2305
            |..|||.||||||.:|||::.|:|::.:.|||...|:||.:|.:|..|........:.::||||.
plant  2024 DETARGNVLEPEGTIEIKFRTKELLECMGRLDQKLISLKAKLQDAKQSEAYANIELLQQQIKARE 2088

  Fly  2306 AVLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQ- 2369
            ..|:.||..:|..||:||||..||..|..|..:|.|..||.:.|.:|.|.:.|.:.:|.:..|.
plant  2089 KQLLPVYIQIATKFAELHDTSMRMAAKGVIKSVVEWSGSRSFFYKKLNRRIAESSLVKNVREASG 2153

  Fly  2370 DNLSVGQAKQMLRRWLVEE---KGATEAYLWDKNEEMVSW------YE---EQINAESIVSR--- 2419
            |||:...:.::::.|....   ||..||  |..::...:|      ||   .::.|:.::::
plant  2154 DNLAYKSSMRLIQDWFCNSDIAKGKEEA--WTDDQVFFTWKDNVSNYELKLSELRAQKLLNQLAE 2216

  Fly  2420 -------------------NVNSVRRDAIISTISKML 2437
                               .|...:|:.:::.|.|:|
plant  2217 IGNSSDLQALPQGLANLLNKVEPSKREELVAAIRKVL 2253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	290/507 (57%)
		CPSase_L_chain	260..379	CDD:278706	74/118 (63%)
		ATP-grasp_4	384..607	CDD:302634	131/223 (59%)
		Biotin_carb_C	644..751	CDD:280880	62/106 (58%)
		biotinyl_domain	891..952	CDD:133459	20/60 (33%)
		ACC_central	956..1700	CDD:285519	186/807 (23%)
		Carboxyl_trans	1800..2344	CDD:279390	282/544 (52%)
ACC1	NP_001185143.1	CPSase_L_chain	37..156	CDD:278706	74/118 (63%)
		AccC	40..545	CDD:223516	289/504 (57%)
		ATP-grasp_4	161..385	CDD:302634	131/223 (59%)
		Biotin_carb_C	432..539	CDD:280880	62/106 (58%)
		AccB	601..741	CDD:223585	50/139 (36%)
		biotinyl_domain	679..741	CDD:133459	21/61 (34%)
		ACC_central	744..1485	CDD:285519	186/807 (23%)
		Carboxyl_trans	1587..2139	CDD:279390	287/556 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	561	1.000	Domainoid score	I46
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31015
Inparanoid	1	1.050	1352	1.000	Inparanoid score	I12
OMA	1	1.010	-	-		QHG53830
OrthoDB	1	1.010	-	-		D156081at2759
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		otm3180
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	LDO	PTHR45728
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980