DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and Acaca

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	XP_038942680.1	Gene:	Acaca / 60581	RGDID:	621248	Length:	2384	Species:	Rattus norvegicus

Alignment Length:	2384	Identity:	1447/2384 - (60%)
Similarity:	1797/2384 - (75%)	Gaps:	107/2384 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SINKNQNNNSIDISISISKMSETNESNDTAAQSAEGERPSFLVGDEIDERAAEAGEACDEFPLKM 205
            ::..||::..|     |..:||.|..::.          |.||..:::|:.....      |..:
  Rat    49 TLELNQHSRFI-----IGSVSEDNSEDEI----------SNLVKLDLEEKEGSLS------PASV 92

  Fly   206 QNDVRQNGDISERRK----RLRPSMSRGTGL-----GQDRHQ---DRDFHIATTEEFVKRFGGTR 258
            .:|...:..||..:.    .:|.|||   ||     |:||.:   .|||.:|:..|||.||||.:
  Rat    93 SSDTLSDLGISALQDGLAFHMRSSMS---GLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNK 154

  Fly   259 VINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG 323
            ||.|||||||||||||||||||||:||||:|||||||||||||||||||||||||||||||||||
  Rat   155 VIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG 219

  Fly   324 SNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVAS 388
            :|||||||||||:|||.|..|||||||||||||||||||||.|.|:.|:|||.:||||||||:||
  Rat   220 ANNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIAS 284

  Fly   389 SIVAQTAEIPTLPWSGSDLKA-----QYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIK 448
            |||||||.|||||||||.|:.     .:|.:.:.:..:|:.:|.|.:|:.||.|..::|:|||||
  Rat   285 SIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQDLYEKGYVKDVDDGLKAAEEVGYPVMIK 349

  Fly   449 ASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGR 513
            |||||||||||:|:..::||.|||||||||||||||||:||:.:||||||:||||||||||||||
  Rat   350 ASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGR 414

  Fly   514 DCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPR 578
            |||:|||||||||||||.:|.|.|||.||:.||:|||||||||||||||||..:|.::|||||||
  Rat   415 DCSVQRRHQKIIEEAPAAIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPR 479

  Fly   579 LQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVI 643
            |||||||||||||||||||||||.|||||:|:||||::||.||||.:.|||||..:.|.|.||||
  Rat   480 LQVEHPCTEMVADVNLPAAQLQIAMGIPLFRIKDIRMMYGVSPWGDAPIDFENSAHVPCPRGHVI 544

  Fly   644 AARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQAR 708
            |||||||||||||||||||||||||||:|||||||||||:|||||||||||||||||||||::|.
  Rat   545 AARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAI 609

  Fly   709 ENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVMCGS 773
            .|:|:|||||||||||||||||||.||||..|..|.|||.|||.||||:||:|:||.:|||:||:
  Rat   610 SNMVVALKELSIRGDFRTTVEYLIKLLETESFQLNRIDTGWLDRLIAEKVQAERPDTMLGVVCGA 674

  Fly   774 LHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSF 838
            ||:||..:..|.|:|..|||:||:..|:||.|.||||||.:||:|.::..:...|||.::||.|.
  Rat   675 LHVADVNLRNSISNFLHSLERGQVLPAHTLLNTVDVELIYEGIKYVLKVTRQSPNSYVVIMNGSC 739

  Fly   839 KEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMI 903
            .|::||||||||||:|.:|:|||||||||||||||.|||:|||||||||||::|||||||||..|
  Rat   740 VEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYI 804

  Fly   904 VEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQP 968
            ||||.||..||.||||||||||||||:.|:|.:.:|:||||.||.|.::..::||:||.|.:|:.
  Rat   805 VEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVIAKMQLDNPSKVQQAEL 869

  Fly   969 FKGQFLQPENAPV-PEKLNRVHNTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPL 1032
            ..|...|.::..: .|||:||.:.....|.|.:.|||||:||.:.:::|.:|:.|::||||||||
  Rat   870 HTGSLPQIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPL 934

  Fly  1033 LELQEVIASISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVF 1097
            ||||:::.|:|||||::|||.|:|.|..|..||||||.||||||||:::|||||||.::::|:||
  Rat   935 LELQDIMTSVSGRIPLNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVF 999

  Fly  1098 FLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHNKDDMQTVVN 1162
            |:.||||||||||||:||||.|||.|.:|||||..||:|||.|||||||..:||.||.||.||:|
  Rat  1000 FMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLN 1064

  Fly  1163 TIFSHSQVAKKNLLVTLLIDHLWANEPGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQP 1227
            .||||:||.|||||||:|||.|...:|.|||||.|.|:|||.|::..:::||||:||||||:|.|
  Rat  1065 YIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLP 1129

  Fly  1228 AYELRHNQMESIFLSAVDMYGHDFHPENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRR 1292
            :|||||||:|||||||:|||||.|..||||:||||||||||:|.:||||||:.|..|||||||||
  Rat  1130 SYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRR 1194

  Fly  1293 AYTSYELTCLQHLELSGGLPLVHFQFLLPTAHPNR----LFSRMSSPD-----GLDQAAAES--- 1345
            ||.:|||..:||.:|.....:|.|||:|||:||||    ..:|||...     |:...|:.|
  Rat  1195 AYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFASNLNHYGMTHVASVSDVL 1259

  Fly  1346 LGNSFV----RTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVEAADSISDSRHST 1406
            |.|:|.    |.|.:.:|.:||.|....||::....|  ||..           :.:..:|.|:
  Rat  1260 LDNAFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFCD--SPPQ-----------SPTFPESGHT- 1310

  Fly  1407 SINVSLSDPVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIRR 1471
                ||.|       .::....|||||::||::..|:::|.::|.:|..:.|::...|.:..|||
  Rat  1311 ----SLYD-------EDKVPRDEPIHILNVAIKTDGDIEDDRLAAMFREFTQQNKATLVEHGIRR 1364

  Fly  1472 ITFAALKK---------------RQFPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTYDL 1521
            :||...:|               |:|||||||||||||.|||||||||||.||.||||||:.:||
  Rat  1365 LTFLVAQKDFRKQVNCEVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDL 1429

  Fly  1522 EALPTANQKMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDE 1586
            .|:|.||.|||||||.|||..|.||||||||:|:|||||||:|||||||||||||||:|||||||
  Rat  1430 TAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDE 1494

  Fly  1587 LEVAFSHPHAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQS 1651
            |||||::.:. |||||||||||||||||||:||||||..|:||||.|||||||||||||:.||.:
  Rat  1495 LEVAFNNTNV-RTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLT 1558

  Fly  1652 PQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQ 1716
            .......:||.:.|:|||:||||:|.|.|:..|..|.|:|||:|||.|||..|:|||:|||.||.
  Rat  1559 TTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQS 1623

  Fly  1717 KRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVLEGD-NLVEMQ 1780
            |||||||.||||:||:|:||||...:.|...|..........|..|| ...||||:.. .||.|.
  Rat  1624 KRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDIL-TYTELVLDDQGQLVHMN 1687

  Fly  1781 RLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRI 1845
            ||||.|..|||||::.|.:||||:||::|||.||:||.|||||.:||:||.:||:|||...:|||
  Rat  1688 RLPGGNEIGMVAWKMSLKSPEYPDGRDVIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRI 1752

  Fly  1846 YISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDEGEQR 1910
            |::.|||||||||||::.||.:||.|.|:|.||:|||||:.:||.:|:.||||....:|||||.|
  Rat  1753 YVAANSGARIGLAEEIRHMFHVAWVDSEDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESR 1817

  Fly  1911 YKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNS 1975
            |||||||||::|||.||||.:|:||||:|.||:||:||::||||.||||:|:||||||.||::||
  Rat  1818 YKITDIIGKEEGLGAENLRGSGMIAGESSLAYDEIITISLVTCRAIGIGAYLVRLGQRTIQVENS 1882

  Fly  1976 HIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCD 2040
            |:||||..||||:|||:||.|||||||.|||.||||||.|...|.:||:|:|.||||:|..:...
  Rat  1883 HLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKNVHSS 1947

  Fly  2041 LPIVLPNDRIERPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTG 2105
            :|::...|.|:|.::|:|||:||||||||.||.:|.....|.:||||..|:||||..||:|||.|
  Rat  1948 VPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVG 2012

  Fly  2106 RARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELP 2170
            ||||||:||||:||||||||:.:||||||||||||.:|||||||:|||::||.||||||.||.||
  Rat  2013 RARLGGIPVGVVAVETRTVELSVPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLP 2077

  Fly  2171 LIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRY 2235
            |:||||||||||||||||:|::||||||||||||..:||::|:||.||||||:|.|:|..||||:
  Rat  2078 LMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTINPRH 2142

  Fly  2236 METYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEK 2300
            ||.|||.|:||.||||||.||||:::||||||:.|:||..|.|.:.|.....|  .....:::.|
  Rat  2143 MEMYADRESRGSVLEPEGTVEIKFRKKDLVKTMRRVDPVYIRLAERLGTPELS--PTERKELESK 2205

  Fly  2301 IKARIAVLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKI 2365
            :|.|...|:.:||.|||.||||||||.||.||..|::|:.|:.||.:.|||||||||||...|||
  Rat  2206 LKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVINDILDWKTSRTFFYWRLRRLLLEDLVKKKI 2270

  Fly  2366 LRAQDNLSVGQAKQMLRRWLVEEKGATEAYLWDKNEEMVSWYEEQINAE----SIVSRNVNSVRR 2426
            ..|...|:.||.:.|||||.||.:|..:||:||.|:::|.|.|:|:..|    |::..|:..:.|
  Rat  2271 HSANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISR 2335

  Fly  2427 DAIISTISKMLEDCPDVALDAVVGLCQGLTPVNRGVVVRTLAQM 2470
            |.::..|..:::..|:||:|::|.:.|.::|..|..|||.|:.|
  Rat  2336 DYVLKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTM 2379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	393/501 (78%)
		CPSase_L_chain	260..379	CDD:278706	103/118 (87%)
		ATP-grasp_4	384..607	CDD:302634	164/227 (72%)
		Biotin_carb_C	644..751	CDD:280880	91/106 (86%)
		biotinyl_domain	891..952	CDD:133459	42/60 (70%)
		ACC_central	956..1700	CDD:285519	436/775 (56%)
		Carboxyl_trans	1800..2344	CDD:279390	347/543 (64%)
Acaca	XP_038942680.1	AccC	156..658	CDD:223516	393/501 (78%)
		AccB	709..856	CDD:223585	98/146 (67%)
		Biotin_lipoyl	791..856	CDD:395290	42/64 (66%)
		ACC_central	858..1607	CDD:400565	436/774 (56%)
		Carboxyl_trans	1707..2255	CDD:395825	349/549 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I68
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31015
Inparanoid	1	1.050	2819	1.000	Inparanoid score	I20
OMA	1	1.010	-	-		QHG53830
OrthoDB	1	1.010	-	-		D10336at33208
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		otm46318
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	O	PTHR45728
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1180
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980