DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and PCB

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	NP_001163103.1	Gene:	PCB / 36020	FlyBaseID:	FBgn0027580	Length:	1197	Species:	Drosophila melanogaster

Alignment Length:	1236	Identity:	295/1236 - (23%)
Similarity:	487/1236 - (39%)	Gaps:	348/1236 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 INKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGS 324
            |..||:||.|..|::..|:.         .|..|:.|.:.:.:| |.:....|..:.|:...|..
  Fly    39 IRSVLVANRGEIAIRVFRAC---------TELGIKSVAVYSEQD-KMHMHRQKADESYIVGKGLP 93

  Fly   325 NNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVASS 389
            ....|.|:..::.:.....|.||..|:|..||.....:.:...||.|:||....:..:|||||:.
  Fly    94 PVEAYLNIPELIRVCKENDVDAVHPGYGFLSERSDFAQAVIDAGLRFIGPSPEVVQKMGDKVAAR 158

  Fly   390 IVAQTAEIPTLPWSGSDLKAQYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGG 454
            :.|..|.:|.:|  |:|                   |.||..|:.|....|.|.||:.||:.|||
  Fly   159 VAAIEAGVPIVP--GTD-------------------GPVTTKEEALEFCKKHGLPVIFKAAYGGG 202

  Fly   455 GKGIRRV----DTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDC 515
            |:|:|.|    |..|.|.....:.:|......:|:.|.....||:|||||.|:.||.:.|:.|||
  Fly   203 GRGMRVVRKMEDVEESFQRASSEAKAAFGNGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDC 267

  Fly   516 SIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPRLQ 580
            |:||||||::|.|||.....|:.:.|.:||||||:.|||.:|||||:|.|..|.::|:|:|.|||
  Fly   268 SVQRRHQKVVEIAPAPRLPIEIRDKMTEAAVRLARHVGYENAGTVEFLCDESGNFYFIEVNARLQ 332

  Fly   581 VEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAA 645
            |||..||.:..::|..:|:::..|:.|..|.     |.:              :|..|.|:.|..
  Fly   333 VEHTVTEEITGIDLVQSQIRVAEGMTLPELG-----YTQ--------------DKIVPRGYAIQC 378

  Fly   646 RITSENPDEGFKPSSGTVQELNFRSSKNVW-GYFSVAASGG--LHEFADSQFGHCFSWGENRQQA 707
            |:|:|:|...|:|::|.::.  |||.:.:. ...|.:|..|  :..:.||......|...:.|.:
  Fly   379 RVTTEDPANDFQPNTGRLEV--FRSGEGMGIRLDSASAYAGAIISPYYDSLLVKVISHASDLQSS 441

  Fly   708 RENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQ--SEKPDI----- 765
            ...:..||:|..||| .:|.:.:|:.:||..:||...:||.::|    |..|  ..||.:
  Fly   442 ASKMNRALREFRIRG-VKTNIPFLLNVLENQKFLHGVLDTYFID----EHPQLFKFKPSLNRAQK 501

  Fly   766 LLGVM-------------------CGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVEL 811
            ||..|                   ..|.|:.:..:..|..:.:.. |:|:.:.......:.:| |
  Fly   502 LLNYMGEVLVNGPQTPLATTLKPALVSPHVPEVPLDLSPEAIERE-ERGEAKVTEPPKGLREV-L 564

  Fly   812 INDGIRYKVQAAKSGANSYFLLMNSSFKEIE--------------------VHRLSDGGLLISLE 856
            :.:|.....:..::  ....|||:::|::..                    .|:.::   |.|||
  Fly   565 VCEGPEAFAKEVRN--RKELLLMDTTFRDAHQSLLATRVRSHDLLKISPYVTHKFNN---LYSLE 624

  Fly   857 ---GASYTTYMK-------EEVDRYRIVIGN------------------------QTC------- 880
               ||::...::       |.::..|..|.|                        :.|
  Fly   625 NWGGATFDVALRFLHECPWERLEEMRKRIPNIPFQMLLRGANAVGYTSYPDNVVYKFCELAVQTG 689

  Fly   881 -----VFEKEND-PSL-LRSPSAGK------------------------------LINMIVEDGA 908
                 ||:..|. |:| |...:|||                              |.:.:|:.|.
  Fly   690 MDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPKRTKYDLKYYTNLADELVKAGT 754

  Fly   909 HVSKGQAYAEI---EVMKMVMTLTSQE---------------AGTVTFVRRPGAVLDAGSLLGHL 955
            ||...:..|.:   |..::::|....:               ||..:.:    |..:||:.:..:
  Fly   755 HVLCIKDMAGLLKPESARLLITAIRDKHPDIPIHIHTHDTSGAGVASML----ACANAGADVVDV 815

  Fly   956 ELDDPSLVTKAQPFKGQFLQP-ENAPVPEKLN-RVHNTYKSILENTLAGYCLPEPF--------- 1009
            .:|..|.:| :||..|..:.. :..|:...|: |..:.|.:..|.|...|.   ||
  Fly   816 AVDSMSGMT-SQPSMGAVVASLQGTPLDTNLDLRTVSEYSAYWEQTRTLYA---PFECTTTMRSG 876

  Fly  1010 ---------------NAQ------RLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKK 1053
                           |.|      .|.|..|...::.|:.:|.|.::.:|..|
  Fly   877 NADVYLNEIPGGQYTNLQFQAFSLGLGDFFEDVKKAYREANLLLGDIIKVTPS------------ 929

  Fly  1054 IRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIVQLVQ--------- 1109
                     ..:...||||..|.     |..|..:.:||:...|   .:|:|:.:|
  Fly   930 ---------SKVVGDLAQFMVQN-----DLTADQVLERAEELSF---PKSVVEYLQGSIGIPHGG 977

  Fly  1110 -----RYR-----NGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHNKDDMQTVVNTI 1164
                 |.|     ..|.||..|.:.:|  .:..::.:.|..|  .||     .|:|.|...:
  Fly   978 FPEPLRSRVLKDMPRIEGRPGAELKDL--DFDKLKKELQESH--TCV-----TNRDVMSAAL--- 1030

  Fly  1165 FSHSQVAKKNLLVTLLIDHL-WANEPGLTDELANTLSELTSLNRAEHSRVAL-RSRQVLIAAHQP 1227
              :.||..         |.| :..:.|..|:| :|...||.....|...|.| |.:.:.:.|...
  Fly  1031 --YPQVTN---------DFLNFREKYGPVDKL-DTRIFLTGPKVGEEFDVPLERGKTLSVKALAV 1083

  Fly  1228 AYELRHNQMESIF------LSAVDMYGHDFHPENLQRLILSETSIFDI-LHDFFYHSNRAVCNAA 1285
            :.:|:.|.:..:|      |.||.              ||.:.::.:| :|.....||::...|.
  Fly  1084 SADLKPNGIREVFFELNGQLRAVH--------------ILDKEAVKEIHVHPKANKSNKSEVGAP 1134

  Fly  1286 L 1286
            :
  Fly  1135 M 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	162/503 (32%)
		CPSase_L_chain	260..379	CDD:278706	30/118 (25%)
		ATP-grasp_4	384..607	CDD:302634	92/226 (41%)
		Biotin_carb_C	644..751	CDD:280880	31/109 (28%)
		biotinyl_domain	891..952	CDD:133459	17/108 (16%)
		ACC_central	956..1700	CDD:285519	80/391 (20%)
		Carboxyl_trans	1800..2344	CDD:279390
PCB	NP_001163103.1	CPSase_L_chain	39..147	CDD:278706	30/117 (26%)
		pyruv_carbox	41..1197	CDD:130302	294/1234 (24%)
		ATP-grasp_4	153..360	CDD:302634	92/227 (41%)
		Biotin_carb_C	377..484	CDD:214878	31/109 (28%)
		DRE_TIM_PC_TC_5S	584..867	CDD:163675	50/293 (17%)
		PYC_OADA	880..1078	CDD:280576	51/250 (20%)
		biotinyl_domain	1130..1196	CDD:133459	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24048at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850