DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACC and ACACB

DIOPT Version :9

Sequence 1:NP_610342.1 Gene:ACC / 35761 FlyBaseID:FBgn0033246 Length:2482 Species:Drosophila melanogaster
Sequence 2:NP_001084.3 Gene:ACACB / 32 HGNCID:85 Length:2458 Species:Homo sapiens


Alignment Length:2532 Identity:1451/2532 - (57%)
Similarity:1825/2532 - (72%) Gaps:144/2532 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLITILGTLAAFLAFLLTLIFGRGQKRSKPV---QSSAATSATTATTGDSDNGNTNHNSSVIAAT 62
            :|:.:...:.:.|.|....|:|: ...|||:   :|.|....:......|||.......:....|
Human     3 LLLCLSCLIFSCLTFSWLKIWGK-MTDSKPITKSKSEANLIPSQEPFPASDNSGETPQRNGEGHT 66

  Fly    63 ATATTTSSKP----------------PIAPAAPPSAVKASDKRFPKACIKKVQFSSESLRSDVDE 111
            ...|.:.::|                |.:...||....:|....|...::.....::.|     |
Human    67 LPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGTGTQGL-----E 126

  Fly   112 LCDQLKDSALSNLSNDNIRIACHQNNNNSSINKNQNN--NSIDISISISKMSETNESNDTAAQSA 174
            ..|       :|..:.:.|....|..:.|..:|.|.|  ..:..:..:....:.:...|:.|.|:
Human   127 ATD-------TNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSS 184

  Fly   175 -----EGERPSFLVGDEIDERAAEAGEACDEFPLKMQNDVRQNGDISERRKRLRPSMSRGTGL-- 232
                 :|.|.|  :|....|.....|||....|                  .:|||||   ||  
Human   185 RESTRKGSRAS--LGALSLEAYLTTGEAETRVP------------------TMRPSMS---GLHL 226

  Fly   233 ---GQDRHQ---DRDFHIATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNER 291
               |::..:   .|||.:|:..|||.||||.|||.||||||||||||||||||||||||||:|||
Human   227 VKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNER 291

  Fly   292 AIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASE 356
            ||||||||||||||||||||||||||||||||.|||||||||||||||.|..|||||||||||||
Human   292 AIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASE 356

  Fly   357 NPKLPELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQYS------GKK 415
            ||||||||.|.|:.|||||..||||||||:||::||||.::||||||||.|..:::      ||:
Human   357 NPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKR 421

  Fly   416 IKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPG 480
            |.:..:::.:|||.:|::||.|..:||||:||||||||||||||:.::.|:||.||||||:|:||
Human   422 ISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPG 486

  Fly   481 SPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAA 545
            ||||:||||:.|||||||:||||||||:||||||||||||||||:|||||.:|...:||.||:.|
Human   487 SPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCA 551

  Fly   546 VRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRL 610
            :||||.|||||||||||||..:|.:.|||||||||||||||||:||||||||||||.||:||:||
Human   552 IRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRL 616

  Fly   611 KDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVW 675
            |||||||||||||.:.|.||.|.|.|...||||||||||||||||||||||||||||||||||||
Human   617 KDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVW 681

  Fly   676 GYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRF 740
            |||||||:|||||||||||||||||||||::|..|:|:|||||||||||||||||||.||||..|
Human   682 GYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESF 746

  Fly   741 LDNSIDTAWLDALIAERVQSEKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQAANTLTN 805
            .:|.|||.|||.||||:||:|||||:|||:||:|::||.......:.|..|||:||:..|::|.|
Human   747 QNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLN 811

  Fly   806 VVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDR 870
            :||||||..|::|.::.|:.....:.|:||....||:.|||:|||||:|..|.|||||||||||.
Human   812 LVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDS 876

  Fly   871 YRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGT 935
            |||.|||:||||||||||::|||||||||....||||.||..|.:|||:|||||:|||..||.|.
Human   877 YRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGR 941

  Fly   936 VTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQPENAPV-PEKLNRVHNTYKSILENT 999
            |.:::||||||:||.::..|||||||.|..|:||.|:....:..|: .|||::|.::....|.|.
Human   942 VKYIKRPGAVLEAGCVVARLELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNV 1006

  Fly  1000 LAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKKIRKLMTLYERN 1064
            ::|:|||||..:.:|::.::|.|.:||.||||||||||::.|::||||..|||.:|::|..|..|
Human  1007 MSGFCLPEPVFSIKLKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASN 1071

  Fly  1065 ITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIVQLVQRYRNGIRGRMKAAVHELLRQ 1129
            |||||.||||||||:::|.||||||::|||:|||:.||||||||||||:||||.||..|.:|||:
Human  1072 ITSVLCQFPSQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRR 1136

  Fly  1130 YYDVESQFQYGHYDKCVGLVREHNKDDMQTVVNTIFSHSQVAKKNLLVTLLIDHLWANEPGLTDE 1194
            |..||..||..||||||..:||..|.||..|::.||||:||||||.||.:|||.|...:|.|:||
Human  1137 YLRVEHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSDE 1201

  Fly  1195 LANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAVDMYGHDFHPENLQRL 1259
            |.:.|:|||.|:::||.:||||:||:|||:|.|:|||||||:|||||||:|||||.|.||||::|
Human  1202 LISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENLKKL 1266

  Fly  1260 ILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELTCLQHLELSGGLPLVHFQFLLPTAH 1324
            |||||:|||:|..||||:|:.||.|:|||||||.|.:|||..|||.:|..|..:|.|||:||::|
Human  1267 ILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSH 1331

  Fly  1325 PNRLFSRMS--SPDGLDQAAAESLGNSF----VRTGAIAAFDSFEHFEMYSDEILDLLEDFVSPA 1383
            |||:...:|  :||.|..:....:.:.|    .|.||:.||..||.|....||::          
Human  1332 PNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVI---------- 1386

  Fly  1384 MVNAKVLEAVEAADSISDSRHSTSINVSLSDPV-----TRANAAEEAKS--TEPIHIVSVAVRET 1441
                                 |...||....|:     |...:.::.||  .|||||::|:::..
Human  1387 ---------------------SCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCA 1430

  Fly  1442 GELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAALKKRQFPKFFTFRARDKFTEDRIYRHLEPA 1506
            ..|:|..:..|...:.|.....|....:|||||...::::|||||||||||:|.|||||||||||
Human  1431 DHLEDEALVPILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPA 1495

  Fly  1507 SAFHLELNRMKTYDLEALPTANQKMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEASFEY 1571
            .||.||||||:.:||.|:|.||.|||||||.|||.:|.||||:|||||:||||||||||||||||
Human  1496 LAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEY 1560

  Fly  1572 LQNEGERVLLEAMDELEVAFSHPHAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGPRLWK 1636
            |||||||:||||||||||||::. :.|||||||||||||||||||.||||||..|:||||.||||
Human  1561 LQNEGERLLLEAMDELEVAFNNT-SVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGSRLWK 1624

  Fly  1637 LRVLQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHG 1701
            |||||||:|:.|||:.......:||.|.|:|||:||||:|.|.|:..:|.|.|.::|.|||..||
Human  1625 LRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGPQHG 1689

  Fly  1702 HPISTPYMTKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKI---L 1763
            ..|:|||:|||.||.||||||:.||||:||.|:||||...:.|            .:|||.   :
Human  1690 MLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLW------------GSPDKYPKDI 1742

  Fly  1764 IECKELVLEGD-NLVEMQRLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKED 1827
            :...||||:.. .||||.||||.|..||||:::...|.|||.||::|||.||:|:.|||||..||
Human  1743 LTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIGSFGPGED 1807

  Fly  1828 VLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQV 1892
            :|:.:||::||...:|:||::.|||||||:|||:|.||.:||.|||:|.||||||||:.:||.::
Human  1808 LLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFKYLYLTPQDYTRI 1872

  Fly  1893 ANLNSVRAILIEDEGEQRYKITDIIGKDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIG 1957
            ::||||....||:.||.||.|||||||||||||||||.:|:||||:|.||||||||::||||.||
Human  1873 SSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIG 1937

  Fly  1958 IGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDG 2022
            ||:|:|||||||||::||||||||.:||||:|||:||.|||||||.|||..|||:|.|...|.:|
Human  1938 IGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITVPDDFEG 2002

  Fly  2023 VYTILDWLSYIPAYIGCDLPIVLPNDRIERPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFD 2087
            |||||:||||:|......:||:.|.|.|:|.::|:|:::||||||||.||.:|.....|::||||
Human  2003 VYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSRAPYDPRWMLAGRPHPTLKGTWQSGFFD 2067

  Fly  2088 RDSWSEIMASWAKTVVTGRARLGGVPVGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPD 2152
            ..|:.||||.||:|||||||||||:||||||||||||||.:||||||||||||.:|||||||:||
Human  2068 HGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVAVPADPANLDSEAKIIQQAGQVWFPD 2132

  Fly  2153 SSYKTAQAIKDFGREELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNA 2217
            |:||||||:|||.||:|||::|||||||||||||||:|::|||||||||||:||:|:|||:||.|
Human  2133 SAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYA 2197

  Fly  2218 ELRGGAWAVLDSLINPRYMETYADPEARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKEL 2282
            |||||:|.|:|:.|||..:|.|||.|:|||||||||.||||:::|||:|::.|:||....|.::|
Human  2198 ELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQL 2262

  Fly  2283 DEANASGDKVRAAQVDEKIKARIAVLMHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRW 2347
            .|.:.| ||.| ..::.::|||..:|:.:||.|||.|||.||||.|||||..||:|:.|:.:|.:
Human  2263 GEPDLS-DKDR-KDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTF 2325

  Fly  2348 LYWRLRRLLLEDAYIKKILRAQDNLSVGQAKQMLRRWLVEEKGATEAYLWDKNEEMVSWYEEQIN 2412
            ||||||||||||...::||:|...||....:.|||||.||.:||.:|||||.|:.:|.|.|:...
Human  2326 LYWRLRRLLLEDQVKQEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQ 2390

  Fly  2413 A----ESIVSRNVNSVRRDAIISTISKMLEDCPDVALDAVVGLCQGLTPVNRGVVVRTLAQM 2470
            |    .|.:..|:..::.|:::.||..::|:.|:||:|.|:.|.|.::|..|..||..|:.|
Human  2391 AGDGPRSTIRENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTM 2452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACCNP_610342.1 AccC 260..757 CDD:223516 392/502 (78%)
CPSase_L_chain 260..379 CDD:278706 106/118 (90%)
ATP-grasp_4 384..607 CDD:302634 156/228 (68%)
Biotin_carb_C 644..751 CDD:280880 92/106 (87%)
biotinyl_domain 891..952 CDD:133459 39/60 (65%)
ACC_central 956..1700 CDD:285519 419/757 (55%)
Carboxyl_trans 1800..2344 CDD:279390 354/543 (65%)
ACACBNP_001084.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..155 21/131 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..193 4/18 (22%)
AccC 260..763 CDD:223516 392/502 (78%)
CPSase_L_chain 260..379 CDD:278706 106/118 (90%)
ATP-grasp_4 420..613 CDD:302634 138/192 (72%)
Biotin_carb_C 650..757 CDD:280880 92/106 (87%)
Biotin_lipoyl 895..961 CDD:278778 39/65 (60%)
ACC_central 962..1688 CDD:285519 419/757 (55%)
Carboxyltransferase. /evidence=ECO:0000255|PROSITE-ProRule:PRU01138 1695..2345 414/663 (62%)
Carboxyl_trans 1780..2328 CDD:279390 356/549 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159499
Domainoid 1 1.000 810 1.000 Domainoid score I71
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2809 1.000 Inparanoid score I23
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53830
OrthoDB 1 1.010 - - D10336at33208
OrthoFinder 1 1.000 - - FOG0001818
OrthoInspector 1 1.000 - - otm42167
orthoMCL 1 0.900 - - OOG6_101052
Panther 1 1.100 - - LDO PTHR45728
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11
SonicParanoid 1 1.000 - - X1180
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.940

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