DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and ACACA

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	XP_016880042.1	Gene:	ACACA / 31	HGNCID:	84	Length:	2391	Species:	Homo sapiens

Alignment Length:	2376	Identity:	1445/2376 - (60%)
Similarity:	1788/2376 - (75%)	Gaps:	98/2376 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NSIDISISISKMSETNESNDTAAQSAEGERPSFLVGDEIDERAAEAGEACDEFPLKMQNDVRQNG 213
            |.:.:.:.|...|..:|.|      :|.|..:.:..|.::|:.....      |..:.:|...:.
Human    55 NMVFLEVDIYSDSSVSEDN------SEDEISNLVKLDLLEEKEGSLS------PASVGSDTLSDL 107

  Fly   214 DISERRK----RLRPSMSRGTGL-----GQDRHQ---DRDFHIATTEEFVKRFGGTRVINKVLIA 266
            .||..:.    .:|.|||   ||     |:||.:   .|||.:|:..|||.||||.:||.|||||
Human   108 GISSLQDGLALHIRSSMS---GLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIA 169

  Fly   267 NNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYAN 331
            ||||||||||||||||:||||:|||||||||||||||||||||||||||||||||||.|||||||
Human   170 NNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYAN 234

  Fly   332 VELIVDIALRTQVQAVWAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAE 396
            ||||:|||.|..|||||||||||||||||||||.|.|:.|:|||.:||||||||:|||||||||.
Human   235 VELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAG 299

  Fly   397 IPTLPWSGSDLKA-----QYSGKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGGGK 456
            |||||||||.|:.     .:|.:.:.:..||:.:|.|.:|:.||.|..::|:|||||||||||||
Human   300 IPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGK 364

  Fly   457 GIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRH 521
            |||:|:..::||.|||||||||||||||||:||:.:||||||:|||||||||||||||||:||||
Human   365 GIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRH 429

  Fly   522 QKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPRLQVEHPCT 586
            |||||||||.:|.|.|||.||:.||:|||||||||||||||||..:|.::|||||||||||||||
Human   430 QKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCT 494

  Fly   587 EMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSEN 651
            |||||||||||||||.|||||||:||||::||.||||.|.||||:..:.|.|.||||||||||||
Human   495 EMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSEN 559

  Fly   652 PDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALK 716
            |||||||||||||||||||:|||||||||||:|||||||||||||||||||||::|..|:|:|||
Human   560 PDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALK 624

  Fly   717 ELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVMCGSLHIADRQI 781
            ||||||||||||||||.||||..|..|.|||.|||.||||:||:|:||.:|||:||:||:||..:
Human   625 ELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSL 689

  Fly   782 TESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRL 846
            ..|.|:|..|||:||:..|:||.|.||||||.:|::|.::..:...|||.::||.|..|::||||
Human   690 RNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRL 754

  Fly   847 SDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVS 911
            ||||||:|.:|:|||||||||||||||.|||:|||||||||||::|||||||||..|||||.||.
Human   755 SDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVF 819

  Fly   912 KGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQP 976
            .||.||||||||||||||:.|:|.:.:|:||||.||.|.:|..::||:||.|.:|:...|...:.
Human   820 AGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRI 884

  Fly   977 ENAPV-PEKLNRVHNTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIA 1040
            ::..: .|||:||.:.....|.|.:.|||||:||.:.:::|.:|:.|::||||||||||||:::.
Human   885 QSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMT 949

  Fly  1041 SISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIV 1105
            |:|||||.:|||.|:|.|..|..||||||.||||||||:::|||||||.::::|:|||:.|||||
Human   950 SVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIV 1014

  Fly  1106 QLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHNKDDMQTVVNTIFSHSQV 1170
            |||||||:||||.|||.|.:|||||..||:|||.|||||||..:||.||.||.||:|.||||:||
Human  1015 QLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQV 1079

  Fly  1171 AKKNLLVTLLIDHLWANEPGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQ 1235
            .|||||||:|||.|...:|.|||||.|.|:|||.|::..:::||||:||||||:|.|:|||||||
Human  1080 TKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQ 1144

  Fly  1236 MESIFLSAVDMYGHDFHPENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELT 1300
            :|||||||:|||||.|..||||:||||||||||:|.:||||||:.|..|||||||||||.:|||.
Human  1145 VESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELN 1209

  Fly  1301 CLQHLELSGGLPLVHFQFLLPTAHPNR----LFSRMSSPD-----GLDQAAAES---LGNSFV-- 1351
            .:||.:|.....:|.|||:|||:||||    ..:|||...     |:...|:.|   |.|||.
Human  1210 SVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPP 1274

  Fly  1352 --RTGAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVEAADSISDSRHSTSINVSLSD 1414
              |.|.:.:|.:||.|....||::....|  ||..           :.:..::.|:     ||.|
Human  1275 CQRMGGMVSFRTFEDFVRIFDEVMGCFSD--SPPQ-----------SPTFPEAGHT-----SLYD 1321

  Fly  1415 PVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAALKK 1479
                   .::....|||||::||::...:::|.::|.:|..:.|::...|....|||:||...:|
Human  1322 -------EDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQK 1379

  Fly  1480 ---------------RQFPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTYDLEALPTANQ 1529
                           |:|||||||||||||.|||||||||||.||.||||||:.:||.|:|.||.
Human  1380 DFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANH 1444

  Fly  1530 KMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDELEVAFSHP 1594
            |||||||.|||..|.||||||||:|:|||||||:|||||||||||||||:||||||||||||::.
Human  1445 KMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNT 1509

  Fly  1595 HAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQSPQSPTQAV 1659
            :. |||||||||||||||||||:||||||..|:||||.|||||||||||||:.||.:|......:
Human  1510 NV-RTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPI 1573

  Fly  1660 RLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQKRFQAQSN 1724
            ||.:.|:|||:||||:|.|.|:..|..|.|:|||:|||.|||..|:|||:|||.||.|||||||.
Human  1574 RLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSL 1638

  Fly  1725 GTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVLEGD-NLVEMQRLPGENNC 1788
            ||||:||:|:||||...:.|...|..........|..:| ...||||:.. .||.|.||||.|..
Human  1639 GTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML-TYTELVLDDQGQLVHMNRLPGGNEI 1702

  Fly  1789 GMVAWRIVLATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGA 1853
            |||||::...:||||.||:||||.||:||.|||||.:||:||.:||:|||...:||||:|.||||
Human  1703 GMVAWKMTFKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGA 1767

  Fly  1854 RIGLAEEVKAMFKIAWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDEGEQRYKITDIIG 1918
            |||||||::.||.:||.|||:|.||::||||:.:||.:|:.||||....:|||||.|||||||||
Human  1768 RIGLAEEIRHMFHVAWVDPEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIG 1832

  Fly  1919 KDDGLGVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYA 1983
            |::|:|.||||.:|:||||:|.||.||:||::||||.||||:|:||||||.||::|||:||||..
Human  1833 KEEGIGPENLRGSGMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAG 1897

  Fly  1984 ALNKLLGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVLPND 2048
            ||||:|||:||.|||||||.|||.||||||.|...|.:||:|:|.||||:|..:...:|::...|
Human  1898 ALNKVLGREVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKD 1962

  Fly  2049 RIERPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVP 2113
            .|:|.::|:|||:||||||||.||.:|.....|.:||||..|:||||..||:|||.|||||||:|
Human  1963 PIDRIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIP 2027

  Fly  2114 VGVIAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWR 2178
            |||:||||||||:.:||||||||||||.:|||||||:|||::||.||||||.||.|||:||||||
Human  2028 VGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWR 2092

  Fly  2179 GFSGGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPE 2243
            ||||||||||:|::||||||||||||..:|||:|:||.||||||:|.|:||.||||:||.|||.|
Human  2093 GFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSINPRHMEMYADRE 2157

  Fly  2244 ARGGVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARIAVL 2308
            :||.||||||.||||::.||||||:.|:||..|.|.:.|.....|  .....:::.|:|.|...|
Human  2158 SRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELS--TAERKELENKLKEREEFL 2220

  Fly  2309 MHVYHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQDNLS 2373
            :.:||.|||.||||||||.||.||..||:|:.|:.||.:.|||||||||||...|||..|...|:
Human  2221 IPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELT 2285

  Fly  2374 VGQAKQMLRRWLVEEKGATEAYLWDKNEEMVSWYEEQINAE----SIVSRNVNSVRRDAIISTIS 2434
            .||.:.|||||.||.:|..:||:||.|:::..|.|:|:..|    |::..|:..:.||.::..|.
Human  2286 DGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIR 2350

  Fly  2435 KMLEDCPDVALDAVVGLCQGLTPVNRGVVVRTLAQM 2470
            .:::..|:||:|:::.:.|.::|..|..|:|.|:.|
Human  2351 SLVQANPEVAMDSIIHMTQHISPTQRAEVIRILSTM 2386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	395/501 (79%)
		CPSase_L_chain	260..379	CDD:278706	103/118 (87%)
		ATP-grasp_4	384..607	CDD:302634	165/227 (73%)
		Biotin_carb_C	644..751	CDD:280880	91/106 (86%)
		biotinyl_domain	891..952	CDD:133459	42/60 (70%)
		ACC_central	956..1700	CDD:285519	435/775 (56%)
		Carboxyl_trans	1800..2344	CDD:279390	351/543 (65%)
ACACA	XP_016880042.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	810	1.000	Domainoid score	I71
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31015
Inparanoid	1	1.050	2809	1.000	Inparanoid score	I23
Isobase	1	0.950	-	0	Normalized mean entropy	S894
OMA	1	1.010	-	-		QHG53830
OrthoDB	1	1.010	-	-		D10336at33208
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		otm42167
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	O	PTHR45728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11
SonicParanoid	1	1.000	-	-		X1180
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.960