DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACC and cut6

DIOPT Version :9

Sequence 1:	NP_610342.1	Gene:	ACC / 35761	FlyBaseID:	FBgn0033246	Length:	2482	Species:	Drosophila melanogaster
Sequence 2:	NP_593271.1	Gene:	cut6 / 2543344	PomBaseID:	SPAC56E4.04c	Length:	2280	Species:	Schizosaccharomyces pombe

Alignment Length:	2293	Identity:	1032/2293 - (45%)
Similarity:	1442/2293 - (62%)	Gaps:	165/2293 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 EEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFVVMVTPEDLKANAEYIK 312
            ::::...||..||..:|||||||||||.:||||:||||.|.|||||:|.||.||:|||.||:||:
pombe    57 KDYIASHGGHTVITSILIANNGIAAVKEIRSIRKWAYETFNNERAIKFTVMATPDDLKVNADYIR 121

  Fly   313 MADHYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLPELL--HKEGLVFLGPP 375
            |||.||.||||||||||||||||||||.|..|.|||||||||||||||||:|  ..:.:||:|||
pombe   122 MADQYVEVPGGSNNNNYANVELIVDIAERMNVHAVWAGWGHASENPKLPEMLSASSKKIVFIGPP 186

  Fly   376 ERAMWALGDKVASSIVAQTAEIPTLPWSGSDL---KAQYSGKKIKISSELFARGCVTNVEQGLAA 437
            ..||.:||||::|:||||:|.:|.:.|||::|   :.......:.:..:::.:.|:.:.|:|:|.
pombe   187 GSAMRSLGDKISSTIVAQSARVPCMSWSGNELDQVRIDEETNIVTVDDDVYQKACIRSAEEGIAV 251

  Fly   438 VNKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSPIFVMKLARGARHLEVQLLAD 502
            ..|||:||||||||||||||||:|.:||:|...|:||..|:||||:||||||..|||||||:|||
pombe   252 AEKIGYPVMIKASEGGGGKGIRQVTSTEKFAQAFQQVLDELPGSPVFVMKLAGQARHLEVQILAD 316

  Fly   503 QYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVRLAKMVGYVSAGTVEYLYDPE 567
            ||||.|||||||||:||||||||||||..:|....|.:||:|||||.::|||.||||:||||:||
pombe   317 QYGNNISLFGRDCSVQRRHQKIIEEAPVTIAPAATFHEMERAAVRLGELVGYASAGTIEYLYEPE 381

  Fly   568 G-RYFFLELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLKDIRLLYGESPWGSSVID--F 629
            . |::|||||||||||||.||||:.|||||||||:.||:||.|:..||.|||....|.|.||  |
pombe   382 NDRFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQVAMGLPLSRIPHIRELYGLPRDGDSEIDFFF 446

  Fly   630 ENPPN-----KPRPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAASGGLHEF 689
            :||.:     .|.|.||.:|.|||||:|.||||||||.:::||||||.||||||||..:||:|||
pombe   447 QNPESFKVQKVPTPKGHCVACRITSEDPGEGFKPSSGMIKDLNFRSSSNVWGYFSVGTAGGIHEF 511

  Fly   690 ADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLETNRFLDNSIDTAWLDALI 754
            |||||||.||:.|:|:.:|:::|:||||||||||||||||||:.||||..|.:|...|.|||.||
pombe   512 ADSQFGHIFSFAESRESSRKSMVVALKELSIRGDFRTTVEYLVRLLETKEFSENEFTTGWLDRLI 576

  Fly   755 AERVQSEKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQAANTLTNVVDVELINDGIRYK 819
            |::|.|.:||.:|.|:||:|..|.......:.:|::.||:||:.:...|.||.|:|.|.|..||:
pombe   577 AQKVTSARPDKMLAVVCGALVRAHATADTQYRAFKSYLERGQVPSREFLKNVYDIEFIYDNTRYR 641

  Fly   820 VQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYTTYMKEEVDRYRIVIGNQTCVFEK 884
            ..|::|...||.|.:|.|.....|..|:|||||:.|.|.|||.|.::||...||.|.|.:|:.|:
pombe   642 FTASRSSPGSYHLFLNGSRCTAGVRSLTDGGLLVLLNGHSYTVYYRDEVTGTRISIDNLSCMLEQ 706

  Fly   885 ENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVMTLTSQEAGTVTFVRRPGAVLDAG 949
            ||||:.||:||.|||:..:||.|.|:..|:||||:|||||:|.|.:.|.|.|..:::|||.||||
pombe   707 ENDPTQLRTPSPGKLVRFLVETGEHIKAGEAYAEVEVMKMIMPLVATEDGVVQLIKQPGASLDAG 771

  Fly   950 SLLGHLELDDPSLVTKAQPFKGQ---FLQPE---NAPVPEKLNRVHNTYKSILENTLAGYCLPEP 1008
            .:||.|.|||||.||.|.||.||   :.:|:   |.|    ..|.| ....||.:.|.||
pombe   772 DILGILTLDDPSRVTHALPFDGQLPNWGEPQIAGNKP----CQRYH-ALLCILLDILKGY----- 826

  Fly  1009 FNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRI-PISVEKKIRKLMTLYERNITSVLAQF 1072
            .|...|.....:|::.||:..||..|.....:::..|| |:     :.||.........|..|:|
pombe   827 DNQIILNSTYNEFVEVLRNHELPYSEWSAHYSALVNRISPV-----LDKLFVSIIEKARSRKAEF 886

  Fly  1073 PSQQIASVIDSHA-----ATLQKRADRDVFFLTTQ--SIVQLVQRYRNGIRGRMKAAVHE----- 1125
            |::|:...|.::.     ||.|:        |..|  .:::::..|::|::      |||
pombe   887 PAKQLEVAIQTYCDGQNLATTQQ--------LKVQIAPLLKIISDYKDGLK------VHEYNVIK 937

  Fly  1126 -LLRQYYDVESQFQ--YGHYDKCVGLVREHNKDDMQTVVNTIFSHSQV-AKKNLLVTLLIDHLWA 1186
             ||.:||:||..|.  ....:..:..:|:.||||:..|:....|||:: :|.|||:|:|  .|..
pombe   938 GLLEEYYNVEKLFSGINKREEDVILRLRDENKDDVDKVIALALSHSRIGSKNNLLITIL--DLMK 1000

  Fly  1187 NEPGLTDEL--ANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAV--DMY 1247
            :||.....|  .:.|.:||.|:....|:|:|::|::||....|:...|.:|||.|..|:|  ..|
pombe  1001 SEPSTFVSLYFNDILRKLTDLDSRVTSKVSLKARELLITCAMPSLNERFSQMEHILKSSVVESHY 1065

  Fly  1248 GHDFHPEN------LQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYE-LTCLQHL 1305
            |.......      |:.||.|:.::||:|..||.|::..|..|||||||||||.:|. |....|.
pombe  1066 GDAKFSHRTPSLDILKELIDSKYTVFDVLPAFFCHTDPWVSLAALEVYVRRAYRAYSVLEINYHT 1130

  Fly  1306 ELSGGLPLV---HFQFLLPTAHPNRLFSRMSSPDGLDQAAAESLGNSFVRTGAIAAFDSFEHFEM 1367
            |  .|.|.|   .||.            ..|...||  .|..:.|::|    ..:...|:|:...
pombe  1131 E--AGTPYVLTWRFQL------------HSSGAPGL--GANSTNGSNF----PASTTPSYENSNR 1175

  Fly  1368 YSDEILDL--------LEDFVSPAMVNAKVLEAVE-----AADSISDSRHSTSINVSLSDPVTRA 1419
            ....:.||        .|.|....|:.|:..:.:|     |.|.:..||:..:..::|....:.|
pombe  1176 RLQSVSDLSWYVNKTDSEPFRFGTMIAAETFDELENNLALAIDRLPLSRNYFNAGLTLDGNSSSA 1240

  Fly  1420 NAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAA--LKKRQF 1482
            |    ..:.|..::|:||:..||:|||..:.........:..::|.:..:||:|...  :.|..:
pombe  1241 N----DNTQELTNVVNVALTSTGDLDDSAIVSKLNQILSDFRDDLLEHNVRRVTIVGGRINKSAY 1301

  Fly  1483 PKFFTFR--ARDK------FTEDRIYRHLEPASAFHLELNRMKTYDLEALPTANQKMHLYLGKAK 1539
            |.::|:|  |..|      :.||...||:|||.||.|||.|:..:::|.:.|.|..:|:|...||
pombe  1302 PSYYTYRVSAEQKDGNLVHYNEDERIRHIEPALAFQLELGRLSNFNIEPVFTDNHNIHVYRATAK 1366

  Fly  1540 VSKGQEVTDYRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDELEVAFSHPHAKRTDCNHI 1604
                ...||.|||.|:::|...|..:..:.|||.:|..|::.:.:|.||| ..|   ::||.|||
pombe  1367 ----NMDTDKRFFTRALVRPGRLRDEIPTAEYLISETHRLINDILDALEV-IGH---EQTDLNHI 1423

  Fly  1605 FLNFVPTVIMDPAKIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQSPQSPTQAVRLCIANDSGY 1669
            |:||.|...:.|.::|.::...:.|:|.|||:|||..||::::......:....:|:.|:|.||:
pombe  1424 FINFTPAFGLAPKQVEAALGGFLERFGRRLWRLRVTAAEIRIICTDPSTNTLFPLRVIISNVSGF 1488

  Fly  1670 FLDISMYTE-QTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQKRFQAQSNGTTYVYDVP 1733
            .:::.:|.| :||..:.|  ||:.|: .||:|..||||||.||::||.:|::||..|||:|||.|
pombe  1489 VVNVEIYAEVKTENNSWI--FKSIGQ-PGSMHLRPISTPYPTKEWLQPRRYKAQLMGTTFVYDFP 1550

  Fly  1734 DMFRQMTERHWREFSKARPTVDIRTPDKILIECKELVL-EGDNLVEMQRLPGENNCGMVAWRIVL 1797
            ::||:.....|::....|..|.|  |.. :.||||||. |...|.|:.|.||.|:||||||.|.:
pombe  1551 ELFRRAFTDSWKKVPNGRSKVTI--PQN-MFECKELVADEHGVLQEVNREPGTNSCGMVAWCITV 1612

  Fly  1798 ATPEYPNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVK 1862
            .||||||||:|||:|||:|:.|||||.:||..|.|.:|||||..:||||::.|||||||:|:|:.
pombe  1613 KTPEYPNGRKIIVVANDITFQIGSFGPQEDEYFYKVTQLARQRGIPRIYLAANSGARIGVADEIV 1677

  Fly  1863 AMFKIAWEDPEEPDKGFKYLYLSTEDYAQV----ANLNSVRAILIEDEGEQRYKITDIIGKDDGL 1923
            .:|.|||.||:.|:|||.|:||:.|.|.::    .|:.:...::.| .||.|:|||.|||..:||
pombe  1678 PLFNIAWVDPDSPEKGFDYIYLTPEAYERLQKENPNILTTEEVVTE-TGELRHKITTIIGSSEGL 1741

  Fly  1924 GVENLRYAGLIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKL 1988
            |||.||.:|||||.||:||.:|.|..:||||.:|||:|:||||||.:||:...|||||..||||:
pombe  1742 GVECLRGSGLIAGVTSRAYNDIFTCTLVTCRAVGIGAYLVRLGQRAVQIEGQPIILTGAPALNKV 1806

  Fly  1989 LGRKVYASNNQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVLPNDRIERP 2053
            |||:||.||.||||||:|..||::|.|...|.||:..|::|:||||......:||...:|..:|.
pombe  1807 LGREVYTSNLQLGGTQVMHRNGISHLTSQDDFDGISKIVNWISYIPDKRNNPVPISPSSDTWDRD 1871

  Fly  2054 VDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGVIA 2118
            |:|.|:::.|||||::.|:   .:.:.:..|.||:.|:.|.:..||||||.||||:||:|.||||
pombe  1872 VEFYPSQNGYDPRWLIAGK---EDEDSFLYGLFDKGSFQETLNGWAKTVVVGRARMGGIPTGVIA 1933

  Fly  2119 VETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGR-EELPLIVFANWRGFSG 2182
            |||||:|..:||||||.||..:.|.:|||||||:|::||||||.||.. |:|||.:.||||||||
pombe  1934 VETRTIENTVPADPANPDSTEQVLMEAGQVWYPNSAFKTAQAINDFNHGEQLPLFILANWRGFSG 1998

  Fly  2183 GMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPEARGG 2247
            |.:||:.:::|:|:||||.|..||:||.:|:||.:|||||:|.|:|..||...||.|||.|:|.|
pombe  1999 GQRDMFNEVLKYGSYIVDALASYKQPVFVYIPPFSELRGGSWVVVDPTINEDQMEMYADEESRAG 2063

  Fly  2248 VLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARIAVLMHVY 2312
            ||||||:|.||::.:.|:..:.|.|....:|..||...:.|.|.:...:|  |:..|...||.:|
pombe  2064 VLEPEGMVSIKFRREKLLSLMRRCDHKYASLCNELKRDDLSADDLSTIKV--KLMEREQKLMPIY 2126

  Fly  2313 HTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQDNLSVGQA 2377
            ..:::|||||||...||:.|:.:.:.:.|.::||:.||||||.|.|...::||.:...:|::.::
pombe  2127 QQISIHFADLHDRVGRMVAKKVVRKPLKWTEARRFFYWRLRRRLNEHYALQKITQLIPSLTIRES 2191

  Fly  2378 KQMLRRWLVEEKGATEAYLWDKNEE-MVSWYEEQINAESIVSRNVNSVRRDAIISTISKMLEDCP 2441
            ::.|::|..|..|..:   ||:::: :|.|.||.   ...:|:....::.......:||:|....
pombe  2192 REYLQKWYEEWCGKQD---WDESDKSVVCWIEEH---NDDLSKRTQELKSTYYSERLSKLLRSDR 2250

  Fly  2442 DVALDAVVGLCQGLTPVN 2459
            ...:|:   |.|.||.::
pombe  2251 KGMIDS---LAQVLTELD 2265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	329/509 (65%)
		CPSase_L_chain	260..379	CDD:278706	88/120 (73%)
		ATP-grasp_4	384..607	CDD:302634	140/226 (62%)
		Biotin_carb_C	644..751	CDD:280880	73/106 (69%)
		biotinyl_domain	891..952	CDD:133459	33/60 (55%)
		ACC_central	956..1700	CDD:285519	243/804 (30%)
		Carboxyl_trans	1800..2344	CDD:279390	284/548 (52%)
cut6	NP_593271.1	AccC	69..579	CDD:223516	329/509 (65%)
		CPSase_L_chain	69..190	CDD:278706	88/120 (73%)
		ATP-grasp_4	240..423	CDD:302634	128/182 (70%)
		Biotin_carb_C	466..573	CDD:280880	73/106 (69%)
		AccB	630..779	CDD:223585	74/148 (50%)
		Biotin_lipoyl	711..777	CDD:278778	35/65 (54%)
		ACC_central	778..1517	CDD:285519	243/804 (30%)
		Carboxyl_trans	1615..2170	CDD:279390	292/560 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	590	1.000	Domainoid score	I29
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31015
Inparanoid	1	1.050	1771	1.000	Inparanoid score	I7
OMA	1	1.010	-	-		QHG53830
OrthoFinder	1	1.000	-	-		FOG0001818
OrthoInspector	1	1.000	-	-		oto102042
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	LDO	PTHR45728
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11
SonicParanoid	1	1.000	-	-		X1180
TreeFam	0	0.000	Not matched by this tool.
	12	12.000