Protein Alignment ACC and T28F3.5

DIOPT Version :9

• Sequence 1: NP_610342.1
• Gene: ACC / 35761
• FlyBaseID: FBgn0033246
• Length: 2482
• Species: Drosophila melanogaster
• Sequence 2: NP_001255934.2
• Gene: T28F3.5 / 178510
• WormBaseID: WBGene00012131
• Length: 1612
• Species: Caenorhabditis elegans
• Alignment Length: 2047
• Identity: 614/2047 - (29%)
• Similarity: 933/2047 - (45%)
• Gaps: 563/2047 - (27%)

  Fly   232 LGQDRHQDRDFHIATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEMFKNERAIRFV 296
            ||.:...|.|.:  ..:||||...|.|.|.::|:||||:||:||:.|||:|....|.....:.||
 Worm     4 LGDENSSDPDSN--KIDEFVKMLEGGRSIKRILVANNGLAAMKCLISIRQWLQNQFGTSGVVSFV 66

  Fly   297 VMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAGWGHASENPKLP 361
            .:.|.:::::.:.|:|:||..|..|.|||:.|:||.::|:.:|:..||.||:.|||||||||:|.
 Worm    67 CIATEDEMRSASHYLKLADEIVMAPAGSNSKNFANCDVIIRLAVEAQVDAVYVGWGHASENPELC 131

  Fly   362 ELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQ-------YSGKKIKIS 419
            ..|....::|:||.|:::.|.|||:.|:|:||:..:||:.|:||.:|.:       |
 Worm   132 RRLELNNIIFIGPSEKSIIASGDKIVSTIIAQSIGMPTVTWTGSGVKVEECVDFEHY-------- 188

  Fly   420 SELFARGCVTNVEQGLAAVNK--IGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQVQAEVPGSP 482
            .||.::..:.||::||.|:.|  ||.|:||||||||||||||:.:..::|..||::|:.|.|.||
 Worm   189 HELRSKATIRNVKEGLEAIEKYGIGVPMMIKASEGGGGKGIRKCENMDDFKRLFKEVELEFPNSP 253

  Fly   483 IFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFEDMEKAAVR 547
            ||:||...||||:|:|:|.|::|:.|:|..|||:||||.||:||||||.:...||.:.|:|.|:.
 Worm   254 IFLMKCMDGARHVEIQILGDKHGDVIALSSRDCTIQRRCQKVIEEAPASIVPGEVMQKMKKDAIA 318

  Fly   548 LAKMVGYVSAGTVEYLYDP-EGRYFFLELNPRLQVEHPCTEMVADVNLPAAQLQIGMGIPLYRLK 611
            .|..|||.||||||.|:.| ...||||||||||||||||||.:.|||:||.|.||.||   .:||
 Worm   319 FANFVGYYSAGTVELLFIPTTNEYFFLELNPRLQVEHPCTESICDVNVPALQYQIAMG---RKLK 380

  Fly   612 DI----RLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSENPDEGFKPSSGTVQELNFRSSK 672
            ||    |....|:...:..:             |.:|||:|.|:|::.|.||:|||:.|.|.|:.
 Worm   381 DIPCIKRFREREATGNAGGV-------------HCMAARVTCEDPNDRFLPSTGTVRSLKFNSTS 432

  Fly   673 NVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYLITLLET 737
            ..|.|||::....:|||||||.||.|:.|.:|.:|..||...|:.|.|...|.|..:|||.||..
 Worm   433 KAWAYFSLSDGSTVHEFADSQIGHVFARGRDRNEAIANLKHGLQNLKIDATFPTQSDYLIDLLSL 497

  Fly   738 NRFLDNSIDTAWLDALIAERVQSEK----PDILLGVMCGSLHIADRQITESFSSFQTSLEKGQIQ 798
            .:|..|..||.|||..||.: :.:|    .|.|:.:...:  |...:|..:|..::..|:.|:|.
 Worm   498 EKFKSNQYDTQWLDKRIASK-EGQKLTLSIDHLIAISAAA--IGRSKIRRAFEKYEHQLKTGKIV 559

  Fly   799 AANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISL-EGASYTT 862
            ....|:...:::|:.:.::|.::..:..:..|.:.|..  :|..|..|..|...::: :|.|...
 Worm   560 LPIELSRCTELDLLMNNLKYTLKVFEETSMKYHVRMGE--QETTVKMLQYGSQTLAIHQGKSTDF 622

  Fly   863 YMKEEVDRYRIVIGNQTCVF--EKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMV 925
            .:::..|.|.|.||.....|  ...||.:.||||..||.:...|:.|..|..||.||:||.||||
 Worm   623 CLEKSDDFYFIKIGGNKLKFPITDTNDATCLRSPYTGKFLEYKVQPGEFVEVGQTYAQIESMKMV 687

  Fly   926 M-TLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQPENAPVPEKLNRVH 989
            . .:|....|.:..:.:.|.:::.||:||.||:|     .:.|         :..|..||.:
 Worm   688 FDVVTKIVPGRLIPIAKEGDLINPGSILGRLEID-----KQVQ---------DQLPTSEKFS--- 735

  Fly   990 NTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKKI 1054
                    ..:.|:.:.|....:|.:.|:|                        ||.|:
 Worm   736 --------GKMKGWKMEEKSYFERAKLILE------------------------GRGPL------ 762

  Fly  1055 RKLMTLYERNITSVLAQFPSQQIASVIDSHAATL--QKRADRDVFFLTTQSIVQLVQRYRNGIRG 1117
                            .:|       :||..:.|  .|....|......|:
 Worm   763 ----------------DYP-------VDSLISGLFYSKECGDDATLSNEQT-------------- 790

  Fly  1118 RMKAAVHELLRQYYDVESQFQ-YGHYDKCVGLVREHNKD--DMQTVVNTIFSHSQVAKKNLLVTL 1179
                  ||||.::.:.|..|. ...:|:.|..:.:.|.|  |.:.||:.|:|:|.
 Worm   791 ------HELLERFLETEQYFDARDSFDESVQNMIKSNVDVLDFENVVDQIYSNSH---------- 839

  Fly  1180 LIDHLWANEPGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAYELRHNQMESIFLSAV 1244
                                               ||:::.||
 Worm   840 -----------------------------------LRTKEKLI---------------------- 847

  Fly  1245 DMYGHDFHPENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAYTSYELTCLQHLELSG 1309
              :|           :||..|...:..|||               :...:..:||..|:.:
 Worm   848 --FG-----------VLSHISKSQVEPDFF---------------IPILWKLFELNHLKEV---- 880

  Fly  1310 GLPLVHFQFLLPTAHPNRLFSRMSSPDGLDQAAAESLGNSFVRTGAIAAFDSFEH--FEMYSDEI 1372
                            |.|.:|:                         .:.|.||  |.:.|.:|
 Worm   881 ----------------NILTARI-------------------------LYRSIEHQDFTVKSCKI 904

  Fly  1373 LDLLEDFVSPAMVNAKVLEAVEAADSISDSRHSTSINVSLSDPVTRANAAEEAKSTEPIHIVSVA 1437
            :.....|                :|.::..:.....:||:|:.:.:|             ::.
 Worm   905 VTHKSGF----------------SDCVASMKFENDTDVSISNCIDQA-------------LIE-- 938

  Fly  1438 VRETGELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAALKKRQFPKFFTFRARDKFTEDRIYRH 1502
                           |.||..|::         ::.|.|
 Worm   939 ---------------FVNYSSEYS---------KLKFVA-------------------------- 953

  Fly  1503 LEPASAFHLELNRMKTYDLEALPTANQKMHLYLGKAKVSKGQEVTDYRFFIRSIIRHSDLITKEA 1567
                       ||:|                                      |..:||
 Worm   954 -----------NRIK--------------------------------------IANNSD------ 963

  Fly  1568 SFEYLQNEGERVLLEAMDELEVAFSHPHAKRTDCNHIFLNFVPTVIMDPAKIEESVTKMIMRYGP 1632
              .|:.::.|.::|:...:||
 Worm   964 --NYIVSDIENLILKRQKQLE-------------------------------------------- 982

  Fly  1633 RLWKLRVLQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQG 1697
                    .||:|.|..|......:.|     |:.|.|        :||
 Worm   983 --------DAEVKEVFIQRAGGSLRFV-----NEFGVF--------RTE---------------- 1010

  Fly  1698 SLHGHPISTPYMTKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTERHWREFSKARPTVDIRTPDKI 1762
            .||....|:.:...|....||..|:.|.|||:||.|.||.      |.....::..:|..:.
 Worm  1011 VLHNSDESSEFSPPDKRDFKRSLARQNRTTYIYDFPRMFA------WVASGSSKEPLDTWSS--- 1066

  Fly  1763 LIECKELVLEGDNL----------VEMQRLPGENNCGMVAWRIVLATPEYPNGREIIVIANDLTY 1817
            .::.:|||::.::.          :|.:...|.|:|.:|||.:.:...:  ...|.::|.||:|:
 Worm  1067 TVQVQELVIDDESSELRFISDLKELEARATEGANSCSVVAWLLNIHIDQ--KNMEFVLIGNDVTH 1129

  Fly  1818 LIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKIAWEDPEEPDKGFKYL 1882
            .:|||...|..||..||:|||:.::|||.||.|||||||||.:|..:.|:..   :.....|.||
 Worm  1130 QVGSFAQPEHRLFEMASKLAREKQIPRINISCNSGARIGLARDVLDVLKVKL---KSNGHDFDYL 1191

  Fly  1883 YLSTEDYAQVANLNSVRAILIEDEGEQRYKITDIIG-KDDGLGVENLRYAGLIAGETSQAYEEIV 1946
            |:...:..::.:.      ::..:.|...:|..:.| |::.:|||||..:|.|.||||:||.||.
 Worm  1192 YVDATEKERIGSQ------IVYKQHENELRIKAVKGKKNEYIGVENLMGSGAIGGETSRAYREIP 1250

  Fly  1947 TIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASNNQLGGTQIMFNNGV 2011
            |...||.|::|||:|..||.:|:||.:.:|:||||.||||.|||:|||||||:|||.:||.:||:
 Worm  1251 TYCYVTGRSVGIGAYTARLARRIIQHEKAHLILTGSAALNTLLGKKVYASNNRLGGIEIMRSNGI 1315

  Fly  2012 THKTEAIDLDGVYTILDWLSYIPAYIGCDLPIV------LPNDRIERPVDFMPTKSPYDPRWMLG 2070
            .|.|.:.||.||..::.|:.|:|| ...:.|..      .|:..:| .|.....:...|.:
 Worm  1316 AHATVSSDLAGVAKLVHWMQYLPA-TQSEFPFFRCFNDQSPSTELE-AVGVTKDEMQLDVK---- 1374

  Fly  2071 GRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGVIAVETRTVEVEMPADPANL 2135
               |.....:.:.|.||.||:.||.:|||.::|||||:|.|:||||||.:.::.|..:.||.:..
 Worm  1375 ---NLFEGFNGKQGLFDTDSFDEIRSSWAASMVTGRAKLNGLPVGVIASQWKSYEKLLLADESVE 1436

  Fly  2136 DSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWRGFSGGMKDMYEQIVKFGAYIVD 2200
            :||.....:|||||||:|::||:|||.||.||.||||:.|:.||||||.|||.:|::.|||:|:|
 Worm  1437 NSEEMITSKAGQVWYPESAFKTSQAISDFNRESLPLIMIASLRGFSGGRKDMSDQVLTFGAHIID 1501

  Fly  2201 GLREYKKPVLIYLPPNAELRGGAWAVLDSLIN 2232
            .|.:|::||::|:|...|||||||||:||.:|
 Worm  1502 ELSQYQQPVIVYIPAGGELRGGAWAVVDSNVN 1533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	AccC	260..757	CDD:223516	234/510 (46%)
		CPSase_L_chain	260..379	CDD:278706	51/118 (43%)
		ATP-grasp_4	384..607	CDD:302634	121/232 (52%)
		Biotin_carb_C	644..751	CDD:280880	49/106 (46%)
		biotinyl_domain	891..952	CDD:133459	24/61 (39%)
		ACC_central	956..1700	CDD:285519	94/750 (13%)
		Carboxyl_trans	1800..2344	CDD:279390	193/440 (44%)
T28F3.5	NP_001255934.2	AccC	30..518	CDD:223516	234/512 (46%)
		CPSase_L_chain	30..149	CDD:278706	51/118 (43%)
		ATP-grasp_4	154..379	CDD:302634	121/235 (51%)
		Biotin_carb_C	404..511	CDD:298715	49/106 (46%)
		AccB	<647..719	CDD:223585	28/71 (39%)
		biotinyl_domain	653..718	CDD:133459	26/64 (41%)
		ACC_central	<791..>876	CDD:285519	29/179 (16%)
		Carboxyl_trans	1115..>1533	CDD:279390	192/437 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I3461
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53830
OrthoDB	1	1.010	-	-		D10336at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14406
orthoMCL	1	0.900	-	-		OOG6_101052
Panther	1	1.100	-	-	O	PTHR45728
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930