DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACC and pod-2

DIOPT Version :9

Sequence 1:NP_610342.1 Gene:ACC / 35761 FlyBaseID:FBgn0033246 Length:2482 Species:Drosophila melanogaster
Sequence 2:NP_001254027.1 Gene:pod-2 / 173500 WormBaseID:WBGene00004076 Length:2165 Species:Caenorhabditis elegans


Alignment Length:2532 Identity:785/2532 - (31%)
Similarity:1227/2532 - (48%) Gaps:527/2532 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SDNGN-------TNHNSSVIAATATATTTSSKPPIAPAAPPSAVKASDKRFPKACIKKVQFSSES 104
            |:||:       .....|::....:...|::||      ||.::..||..           ....
 Worm     5 SENGSQQAPAAAQRRKPSLVYGQFSQEITAAKP------PPWSITFSDGA-----------EDNQ 52

  Fly   105 LRSDVDELCDQLKDSALSNLSNDNIRIACHQNNNNSSINKNQ---------NNNSIDISISISKM 160
            .:..||.:||...|...:.|               .|||..:         .::...:||:.|: 
 Worm    53 EKPPVDSICDVAIDFESATL---------------ESINYVELLGVLGLPFTSSVCQVSINFSQ- 101

  Fly   161 SETNESNDTAAQSAEGERPSF----LVGDEIDERAAEAGEACDEFPLKMQNDVRQNGDISERRKR 221
             :..:..........|::|..    :.|:.:...||:..|:.::|                    
 Worm   102 -QVTDLGRAFTMVVNGQKPDIRTIVVSGNSLTNDAADQYESMEQF-------------------- 145

  Fly   222 LRPSMSRGTGLGQDRHQDRDFHIATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRWAYEM 286
                          .|.    |:|..|   ||    |.|.::|:|.|||||::|:.:.:::.:..
 Worm   146 --------------IHS----HVADIE---KR----RPIKRLLVATNGIAAMRCLMTAKKFLHHT 185

  Fly   287 FKNERAIRFVVMVTPEDLKANAEYIKMAD-HYVPVPGGSNNNNYANVELIVDIALRTQVQAVWAG 350
            |:|:..|.||.|.|.:::::.:|.::|.: .....|.|:|.||:|||:.|:..|::.:|.|||||
 Worm   186 FRNDNLIHFVCMTTEDEIQSMSESLRMPNITLAESPSGTNKNNFANVDEILKHAIKYEVDAVWAG 250

  Fly   351 WGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQ----Y 411
            ||||||||.||..|:...:.|:|||..||::||||:||:|:|||..:||:.||||.:..:    .
 Worm   251 WGHASENPDLPRRLNDHNIAFIGPPASAMFSLGDKIASTIIAQTVGVPTVAWSGSGITMESIERS 315

  Fly   412 SGKKIKISSELFARGCVTNVEQGLAAV--NKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLFRQV 474
            .|..:.:..:|..:.||.|.::||.|:  :.||||:||||||||||||||:....|:|..:|.:|
 Worm   316 RGDFVVVPEDLLEQACVANYKEGLEALKTHNIGFPLMIKASEGGGGKGIRKCTKVEDFKSMFEEV 380

  Fly   475 QAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPEVFE 539
            ..||.|||||:||...||||:|||||||:|.|.||::.||||||||.||||||||||:|...:.:
 Worm   381 AQEVQGSPIFLMKCVDGARHIEVQLLADRYENVISVYTRDCSIQRRCQKIIEEAPAIIASSHIRK 445

  Fly   540 DMEKAAVRLAKMVGYVSAGTVEYLYDP-----EGRYFFLELNPRLQVEHPCTEMVADVNLPAAQL 599
            .|::.||||||.|||.|||||||||.|     |..|:|||||||||||||.||||:::::||.||
 Worm   446 SMQEDAVRLAKYVGYESAGTVEYLYLPASEGQEEHYYFLELNPRLQVEHPTTEMVSNISIPAIQL 510

  Fly   600 QIGMGIPLYRLKDIRLLY-----GESPWGSSV-IDFENPPNKPRPSGHVIAARITSENPDEGFKP 658
            ||.||:||:::||||.||     |:|.....| :|.:.         |.||||||.||||:.|:|
 Worm   511 QIAMGLPLHKIKDIRKLYDLPIDGDSELPDEVLVDTKL---------HAIAARITCENPDDSFRP 566

  Fly   659 SSGTVQELNFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGD 723
            |:|.|.|:||.||::.|.||||.....:|:||||||||.|:.|.:|.:|...:...||.::||..
 Worm   567 STGKVYEINFPSSQDAWAYFSVGRGSSVHQFADSQFGHIFTRGTSRTEAMNTMCSTLKHMTIRSS 631

  Fly   724 FRTTVEYLITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVM--CGSLHIADRQITESFS 786
            |.|.|.||:.|:....|::|:.:|.|||..||.::: :|..:.:.|:  ..:..|...::|..|.
 Worm   632 FPTQVNYLVDLMHDADFINNAFNTQWLDKRIAMKIK-QKCSLSMSVIIAVSAAVIGSSRVTGVFE 695

  Fly   787 SFQTSLEKGQIQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGL 851
            ||:.|:::||::..|.||.....:|:.|...|.::..:|..|::.:::|.|...:.|..|.:|..
 Worm   696 SFEESIDRGQVRPPNDLTETFIFDLVKDLNIYSLKVVRSAENTFVIILNGSKVTVGVKELQNGEF 760

  Fly   852 LISLEGASYTTYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAY 916
            :::.....|....:|..:.|::.:.|:...|||:||.|:|:||..|||:....|||..::.|..|
 Worm   761 MVTHCEIVYRCAFEETKEAYKVTVNNEIITFEKDNDVSVLKSPYTGKLLQWKKEDGDWLNVGDVY 825

  Fly   917 AEIEVMKMVMTLTSQEA-GTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQ----P 976
            |..|.||||..:...:| |.:..|...|..:..||:|..|.....|...:||||.|.||:    .
 Worm   826 ATAESMKMVFQVEVAKAPGRLQRVVNEGDPIHPGSVLAKLVDQTESEADRAQPFHGTFLEWSWHS 890

  Fly   977 ENAPVPEKLNRVHNTYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIAS 1041
            ..|....|.|.                ||.:              .|:|                
 Worm   891 SKANEQSKFND----------------CLAQ--------------CQNL---------------- 909

  Fly  1042 ISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIASVIDSHAATLQKRADRDVFFLTTQSIVQ 1106
            ::|..|:.....|.:|  .:..|                 :||.|                    
 Worm   910 LAGSTPMDSACIITEL--FHHLN-----------------ESHTA-------------------- 935

  Fly  1107 LVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHN---KDDMQTVVNTIFSHS 1168
                       .....:::|||.|.:||..|:...||..||.::|.:   ||    ||.||:||:
 Worm   936 -----------HASEVLNQLLRDYINVEKYFEGKVYDDSVGEIKEDHLSRKD----VVRTIYSHT 985

  Fly  1169 QVAKKNLLVTLLIDHLWANE-----PGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQPA 1228
            |:..||:::..|:..|....     |.|.|    .|.::.:|:..|  .::..:|::|:..|...
 Worm   986 QIKSKNIVMKALLGALKQGSGSKFIPSLLD----NLRQIGNLHHTE--EISNLAREILLFYHSMC 1044

  Fly  1229 YELRHNQMESIFLSAVDMYGHDFH-----PENLQRLILSETSIFDILHDFFYHSNRAVCNAALEV 1288
            |:   |....|..|.:...|.:..     |  |.|  ..::|.:.::|::|:  :..:.:..|:.
 Worm  1045 YK---NNYSEITASGLRPTGQEVKAWLDGP--LSR--RPDSSGWKVIHEYFF--DETIGSQCLDR 1100

  Fly  1289 YVRRAYTSYELTCLQHLELSGGLPLVHFQFLLPTAHPNRLFSRMSSPDGLDQAAAESLGNSFVRT 1353
            ||           ..|:....|                                  |:||::...
 Worm  1101 YV-----------AMHISAEEG----------------------------------SIGNTYPLP 1120

  Fly  1354 GAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVE------AADSISDSRHSTSINVSL 1412
            ......|   ||.:.:           :|...|..||:..:      :.||.:.::...|....|
 Worm  1121 QMKCTID---HFTLTA-----------TPKSFNKVVLKGNKLIVVRLSLDSKTFNQQCFSSEKFL 1171

  Fly  1413 SDPVTRANAAEEAKSTEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELF------------ 1465
            .  ..:.|..:..|.|:.|: ||:.|:.|   |||:..|......::..:.:.            
 Worm  1172 D--CLKTNFRKYCKKTDVIN-VSIFVKIT---DDLEAHQDPSTLTEQEEQRVCYAQNAVVDMKTI 1230

  Fly  1466 ---QRRIRRI-TFAALKKRQFPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTYDLEALPT 1526
               :.|:.|: |...|..|..|:...|. :.:..:||:     ||:::.: |:::.|        
 Worm  1231 LEKEFRVNRVNTVLCLNDRPLPQLTIFE-QVRLEKDRL-----PANSYPV-LSKLST-------- 1280

  Fly  1527 ANQKMHLYLGKAKVSKGQEVTD--YRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDELEV 1589
                       .:||:..:.|.  .:.|:|     ..||....:.|.:|.:..:.:..|:|....
 Worm  1281 -----------VRVSQHDDPTSNFAKLFVR-----QQLIIPGNNAEEVQKKISQAVYLALDNACT 1329

  Fly  1590 AFSHPHAKRTDC------NHIFLNFV------PTVIMDPAKIE---ESVTKMIMRYGPRLWKLRV 1639
            |.....||:|..      ||:|: |:      ..||....::|   :.:|..:..:...|.|.::
 Worm  1330 AAQVAMAKKTKANKTFTSNHVFV-FISCPGLPEKVIGSQEQLEFMKKCITDEVDSHKAILAKHQI 1393

  Fly  1640 LQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMYTEQTEPETGIIKFKAYGEKQGSLHGHPI 1704
            .:.|   |:.:|.....   |:.|.:::|...::  .||.:|...|:                  
 Worm  1394 NEVE---VVYESVDGHK---RIVIRDETGVTTEV--ITEFSEASLGV------------------ 1432

  Fly  1705 STPYMTKDFLQQKRFQAQSNGTTYVYDVP----------------------DMFRQMTERHWREF 1747
               |...:.:::||..|:...::|:||.|                      :|.:.:.|:.||||
 Worm  1433 ---YPVINTIEKKRLAARRVNSSYIYDFPIIFGMAAMNFWKSASSAMELPNEMAQALKEQRWREF 1494

  Fly  1748 SKARPTVDIRTPDKILIECKELVLEGDNLVEM--------QRLPGENNCGMVAWRIVLATPEYPN 1804
                            .:.:|||||...|.|:        :.....||||||||.:.|.|||.|.
 Worm  1495 ----------------FQIRELVLENGVLTEISDAEILKKRSANALNNCGMVAWIMTLYTPEKPR 1543

  Fly  1805 GREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKIAW 1869
            |.::|||.||:|:..||||..||.|||.||..:|:.|:||:.:||||||||||:.::..:.|:..
 Worm  1544 GFDLIVIGNDVTFQSGSFGTAEDDLFAAASTYSREHKLPRVNVSVNSGARIGLSTKISKLVKLQL 1608

  Fly  1870 EDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDEGEQRYKITDIIG-KDDGLGVENLRYAGL 1933
            |:.::|::||:|:|:..|..||:..     .::.|:.|..|.||..:|| |::.:|||||:.:||
 Worm  1609 ENEDKPEQGFEYIYIDGEHKAQIEG-----EVVYEELGNGRLKILAVIGAKNEKIGVENLQGSGL 1668

  Fly  1934 IAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASNN 1998
            |||||::||.|:.|...||.|::|||:|..||..|::|...||:|||||.|||.|||:|||.|||
 Worm  1669 IAGETARAYAEVPTYCYVTGRSVGIGAYTARLAHRIVQHKQSHLILTGYEALNTLLGKKVYTSNN 1733

  Fly  1999 QLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIP---------AYIGCDL---PIVLPNDRIE 2051
            ||||.::||.|||||.....||:|:..::.|:|::|         :..|.|.   .:|:|:|   
 Worm  1734 QLGGPEVMFRNGVTHAVVDNDLEGIAKVIRWMSFLPTPTEEFPFFSKHGDDCSARDVVIPSD--- 1795

  Fly  2052 RPVDFMPTKSPYDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGV 2116
                  ..::.||.|.::..:    |.:: :.|..|..|:.||...|||::|.|||||.|:|:||
 Worm  1796 ------SEQNTYDVRDLIDSK----NLSN-QTGICDTMSFDEICGDWAKSIVAGRARLCGIPIGV 1849

  Fly  2117 IAVETRTVEVEMPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWRGFS 2181
            ::.|.|.....:|||||...|:.:..|:|||||||||::|||:||.|..:|.|||::.|:.||||
 Worm  1850 VSSEFRNFSTIVPADPAIDGSQVQNTQRAGQVWYPDSAFKTAEAINDLNKENLPLMIIASLRGFS 1914

  Fly  2182 GGMKDMYEQIVKFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPEARG 2246
            ||.||||:.::||||.|||.|..|.:||::|:|...||||||||||||.|.|.::...||.::||
 Worm  1915 GGQKDMYDMVLKFGAQIVDALAVYNRPVIVYIPEAGELRGGAWAVLDSKIRPEFIHLVADEKSRG 1979

  Fly  2247 GVLEPEGIVEIKYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARIAVLMHV 2311
            |:|||..:|.||:::..:::.:.|.|||...|....:           .:..|:::.|...|...
 Worm  1980 GILEPNAVVGIKFRKPMMMEMMKRSDPTYSKLSSSTE-----------PEAREQLEERYEELSKT 2033

  Fly  2312 YHTVAVHFADLHDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQDNLSVGQ 2376
            |...:|.|||.||..:||.....:..:....:|||.....||..|.:....:....|...:....
 Worm  2034 YRNASVEFADAHDRWQRMKSVGVVEHVTSLTNSRRLFSELLRNELAKVGMAEIYSSAPHTVKPCL 2098

  Fly  2377 AKQM------LRRWLVEEKGATEAYLWDKNEEMVSWYEEQINAESIVSRNVNSVRRDAIIST 2432
            |..|      ||.::.......|.|     .::..:||.|...:.:::.|.:..|.:..::|
 Worm  2099 ATAMTWVETNLRSYVQPNSSMDEQY-----TQIEQYYETQFVDDLVIAINEDRKRYEQQLNT 2155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACCNP_610342.1 AccC 260..757 CDD:223516 256/514 (50%)
CPSase_L_chain 260..379 CDD:278706 49/119 (41%)
ATP-grasp_4 384..607 CDD:302634 134/233 (58%)
Biotin_carb_C 644..751 CDD:280880 51/106 (48%)
biotinyl_domain 891..952 CDD:133459 23/61 (38%)
ACC_central 956..1700 CDD:285519 147/799 (18%)
Carboxyl_trans 1800..2344 CDD:279390 237/556 (43%)
pod-2NP_001254027.1 CPSase_L_chain 159..279 CDD:278706 49/119 (41%)
ATP-grasp_4 284..518 CDD:302634 134/233 (58%)
Biotin_carb_C 552..659 CDD:280880 51/106 (48%)
AccB 717..865 CDD:223585 44/147 (30%)
biotinyl_domain 799..865 CDD:133459 24/65 (37%)
ACC_central <922..>1037 CDD:285519 38/174 (22%)
Carboxyl_trans 1539..2076 CDD:279390 241/566 (43%)
AccC 159..665 CDD:223516 256/514 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 454 1.000 Domainoid score I254
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1154 1.000 Inparanoid score I108
Isobase 1 0.950 - 0 Normalized mean entropy S894
OMA 1 1.010 - - QHG53830
OrthoDB 1 1.010 - - D10336at33208
OrthoFinder 1 1.000 - - FOG0001818
OrthoInspector 1 1.000 - - otm14406
orthoMCL 1 0.900 - - OOG6_101052
Panther 1 1.100 - - LDO PTHR45728
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11
SonicParanoid 1 1.000 - - X1180
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.960

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