Protein Alignment ACC and Acacb

DIOPT Version :10

• Sequence 1: NP_610342.1
• Gene: ACC / 35761
• FlyBaseID: FBgn0033246
• Length: 2482
• Species: Drosophila melanogaster
• Sequence 2: NP_001390456.1
• Gene: Acacb / 100705
• MGIID: 2140940
• Length: 2469
• Species: Mus musculus
• Alignment Length: 2490
• Identity: 1444/2490 - (57%)
• Similarity: 1808/2490 - (72%)
• Gaps: 144/2490 - (5%)

  Fly    68 TSSKPPIAPAAPPSAVKASDKRFPKACIKKVQFSSESLRSDVDELCDQLKDSALSNLSNDNIRIA 132
            |.|||........:.:.:.:.      :...:.|.|.|:...|..|...:....::...:::..:
Mouse    27 TDSKPLTNSKVEANLLSSEES------LSASELSGEQLQEHGDHSCLSYRGPRDASQQRNSLPSS 85

  Fly   133 CHQNNNNS-SINKNQNNNSIDISISISKMSETNESND-----------TAAQSAEGER------- 178
            |.:...|. |.|....:..:..:.:.:...|..::|.           |.:.|.|..:
Mouse    86 CQRPPRNPLSSNDTWPSPELQTNWTAAPGPEVPDANGLSFPARPPSQRTVSPSREDRKQAHIKRQ 150

  Fly   179 --PSFLVGDEIDERAAEAGEACDEFPLKMQNDVRQN-----GDISE-----------RRKRLRPS 225
              .||::| .:|:.:::...:...|    ||..|::     |.:|:           ....:|||
Mouse   151 LMTSFILG-SLDDNSSDEDPSAGSF----QNSSRKSSRASLGTLSQEAALNTSDPESHAPTMRPS 210

  Fly   226 MSRGTGL-----GQDRHQ---DRDFHIATTEEFVKRFGGTRVINKVLIANNGIAAVKCMRSIRRW 282
            ||   ||     |::..:   .|||.:|:..|||.||||.|||.|||||||||||||||||||||
Mouse   211 MS---GLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGNRVIEKVLIANNGIAAVKCMRSIRRW 272

  Fly   283 AYEMFKNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGSNNNNYANVELIVDIALRTQVQAV 347
            |||||:|||||||||||||||||||||||||||.|||||||.|||||||||||:|||.|..||||
Mouse   273 AYEMFRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNNNYANVELIIDIAKRIPVQAV 337

  Fly   348 WAGWGHASENPKLPELLHKEGLVFLGPPERAMWALGDKVASSIVAQTAEIPTLPWSGSDLKAQYS 412
            |||||||||||||||||.|..:.|||||..||||||||:||:|||||.:|||||||||.|..:::
Mouse   338 WAGWGHASENPKLPELLCKHEIAFLGPPSEAMWALGDKIASTIVAQTLQIPTLPWSGSGLTVEWT 402

  Fly   413 ------GKKIKISSELFARGCVTNVEQGLAAVNKIGFPVMIKASEGGGGKGIRRVDTTEEFPGLF 471
                  ||.|.:..:::.:|||.:|::||.|..|||||:||||||||||||||:.::.|:||.||
Mouse   403 EDSRHQGKCISVPEDVYEQGCVKDVDEGLQAAEKIGFPLMIKASEGGGGKGIRKAESAEDFPMLF 467

  Fly   472 RQVQAEVPGSPIFVMKLARGARHLEVQLLADQYGNAISLFGRDCSIQRRHQKIIEEAPAIVAQPE 536
            ||||:|:||||||:||||:.|||||||:||||||||:||||||||||||||||||||||.:|.|.
Mouse   468 RQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFGRDCSIQRRHQKIIEEAPATIAAPA 532

  Fly   537 VFEDMEKAAVRLAKMVGYVSAGTVEYLYDPEGRYFFLELNPRLQVEHPCTEMVADVNLPAAQLQI 601
            |||.||:.||.|||||||||||||||||..:|.:.|||||||||||||||||:||||||||||||
Mouse   533 VFEFMEQCAVLLAKMVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQI 597

  Fly   602 GMGIPLYRLKDIRLLYGESPWGSSVIDFENPPNKPRPSGHVIAARITSENPDEGFKPSSGTVQEL 666
            .||:||:|||||||||||||||.:.|.||.|.:.|...|||||||||||||||||||||||||||
Mouse   598 AMGVPLHRLKDIRLLYGESPWGVTPIPFETPLSPPIARGHVIAARITSENPDEGFKPSSGTVQEL 662

  Fly   667 NFRSSKNVWGYFSVAASGGLHEFADSQFGHCFSWGENRQQARENLVIALKELSIRGDFRTTVEYL 731
            ||||:|||||||||||:|||||||||||||||||||||::|..|:|:||||||||||||||||||
Mouse   663 NFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYL 727

  Fly   732 ITLLETNRFLDNSIDTAWLDALIAERVQSEKPDILLGVMCGSLHIADRQITESFSSFQTSLEKGQ 796
            :.||||..|.:|.|||.|||.|||:|||:|||||:|||:||:|::||.......:.|..|||:||
Mouse   728 VNLLETESFQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVCGALNVADAMFRTCMTEFLHSLERGQ 792

  Fly   797 IQAANTLTNVVDVELINDGIRYKVQAAKSGANSYFLLMNSSFKEIEVHRLSDGGLLISLEGASYT 861
            :..|::|.|:||||||..||:|.::.|:.....:.|:||....||:.|||:|||||:|..|:|||
Mouse   793 VLPADSLLNIVDVELIYGGIKYALKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGSSYT 857

  Fly   862 TYMKEEVDRYRIVIGNQTCVFEKENDPSLLRSPSAGKLINMIVEDGAHVSKGQAYAEIEVMKMVM 926
            ||||||||.|||.|||:||||||||||::|||||||||:...||||.||..|.:|||:|||||:|
Mouse   858 TYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGDHVEAGSSYAEMEVMKMIM 922

  Fly   927 TLTSQEAGTVTFVRRPGAVLDAGSLLGHLELDDPSLVTKAQPFKGQFLQPENAPV-PEKLNRVHN 990
            ||..||:|.|.:::|||.:|:||.::..|||||||.|..||||.|:....:..|: .|||::|.:
Mouse   923 TLNVQESGRVKYIKRPGVILEAGCVVARLELDDPSKVHAAQPFTGELPAQQTLPILGEKLHQVFH 987

  Fly   991 TYKSILENTLAGYCLPEPFNAQRLRDIIEKFMQSLRDPSLPLLELQEVIASISGRIPISVEKKIR 1055
            .....|.|.::||||||||.:.:|:|.::|.|.:||.||||||||||::.|::||||..|||.:|
Mouse   988 GVLENLTNVMSGYCLPEPFFSMKLKDWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKAVR 1052

  Fly  1056 KLMTLYERNITSVLAQFPSQQ---------------------IASVIDSHAATLQKRADRDVFFL 1099
            ::|..|..||||||.||||||                     ||:::|.||||||::|||:|||:
Mouse  1053 RVMAQYASNITSVLCQFPSQQCWASGTLGKHSTTELHPELLKIATILDCHAATLQRKADREVFFM 1117

  Fly  1100 TTQSIVQLVQRYRNGIRGRMKAAVHELLRQYYDVESQFQYGHYDKCVGLVREHNKDDMQTVVNTI 1164
            .||||||||||||:|.||.|||.|.:|||:|.:||..||..||||||..:||..|.||..|::.|
Mouse  1118 NTQSIVQLVQRYRSGTRGYMKAVVLDLLRKYLNVEHHFQQAHYDKCVINLREQFKPDMTQVLDCI 1182

  Fly  1165 FSHSQVAKKNLLVTLLIDHLWANEPGLTDELANTLSELTSLNRAEHSRVALRSRQVLIAAHQPAY 1229
            ||||||||||.|||:|||.|...:|.|:|||.:.|.|||.|:|:||.:||||:||||||:|.|:|
Mouse  1183 FSHSQVAKKNQLVTMLIDELCGPDPTLSDELTSILCELTQLSRSEHCKVALRARQVLIASHLPSY 1247

  Fly  1230 ELRHNQMESIFLSAVDMYGHDFHPENLQRLILSETSIFDILHDFFYHSNRAVCNAALEVYVRRAY 1294
            ||||||:|||||||:|||||.|.||||::||||||:|||:|..||||.|:.||.|:|||||||.|
Mouse  1248 ELRHNQVESIFLSAIDMYGHQFCPENLKKLILSETTIFDVLPTFFYHENKVVCMASLEVYVRRGY 1312

  Fly  1295 TSYELTCLQHLELSGGLPLVHFQFLLPTAHPNRLF--SRMSSPDGLDQAAAESLGNSF----VRT 1353
            .:|||..|||.||..|..:|.|||:||::||||:.  ..:|:||.|..:....:.:.|    .|.
Mouse  1313 IAYELNSLQHRELPDGTCVVEFQFMLPSSHPNRMAVPISVSNPDLLRHSTELFMDSGFSPLCQRM 1377

  Fly  1354 GAIAAFDSFEHFEMYSDEILDLLEDFVSPAMVNAKVLEAVEAADSISDSRHSTSINVSLSDPVTR 1418
            ||:.||..||.|....||::.        ...|.:       .|::..|:..||:
Mouse  1378 GAMVAFRRFEEFTRNFDEVIS--------CFANVQ-------TDTLLFSKACTSL---------- 1417

  Fly  1419 ANAAEEAKS--TEPIHIVSVAVRETGELDDLQMAQIFGNYCQEHNEELFQRRIRRITFAALKKRQ 1481
             .:.|::||  .|||||::||::....::|..:..:|..:.|.....|....:|||||...::|:
Mouse  1418 -YSEEDSKSLREEPIHILNVAIQCADHMEDEALVPVFRAFVQSKKHILVDYGLRRITFLVAQERE 1481

  Fly  1482 FPKFFTFRARDKFTEDRIYRHLEPASAFHLELNRMKTYDLEALPTANQKMHLYLGKAKVSKGQEV 1546
            |||||||||||:|.|||||||||||.||.|||:||:.:||.|:|.||.|||||||.|||.:|.||
Mouse  1482 FPKFFTFRARDEFAEDRIYRHLEPALAFQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEV 1546

  Fly  1547 TDYRFFIRSIIRHSDLITKEASFEYLQNEGERVLLEAMDELEVAFSHPHAKRTDCNHIFLNFVPT 1611
            ||:|||||:|||||||||||||||||||||||:||||||||||||::. :.||||||||||||||
Mouse  1547 TDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNT-SVRTDCNHIFLNFVPT 1610

  Fly  1612 VIMDPAKIEESVTKMIMRYGPRLWKLRVLQAELKMVIRQSPQSPTQAVRLCIANDSGYFLDISMY 1676
            |||||.||||||..|:||||.|||||||||||:|:.|||:.......:||.|.|:|||:||||:|
Mouse  1611 VIMDPLKIEESVRDMVMRYGSRLWKLRVLQAEVKINIRQTTSDSAIPIRLFITNESGYYLDISLY 1675

  Fly  1677 TEQTEPETGIIKFKAYGEKQGSLHGHPISTPYMTKDFLQQKRFQAQSNGTTYVYDVPDMFRQMTE 1741
            .|.|:..:|.|.|.::|.|||||||..|:|||:|||.||.|||||||.|||||||.|:||||...
Mouse  1676 REVTDSRSGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALF 1740

  Fly  1742 RHWREFSKARPTVDIRTPDKI---LIECKELVLEGD-NLVEMQRLPGENNCGMVAWRIVLATPEY 1802
            :.|            .:|:|.   ::...||||:.. .||||.||||.|..||||:::...||||
Mouse  1741 KLW------------GSPEKYPKDILTYTELVLDSQGQLVEMNRLPGCNEVGMVAFKMRFKTPEY 1793

  Fly  1803 PNGREIIVIANDLTYLIGSFGIKEDVLFAKASQLARQLKVPRIYISVNSGARIGLAEEVKAMFKI 1867
            |.||:.:||.||:|:.||||||.||.|:.:||::||...:|:||::.|||||:|||||:|.:|::
Mouse  1794 PEGRDAVVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANSGARMGLAEEIKQIFQV 1858

  Fly  1868 AWEDPEEPDKGFKYLYLSTEDYAQVANLNSVRAILIEDEGEQRYKITDIIGKDDGLGVENLRYAG 1932
            ||.|||:|.|||:||||:.:||.|:::.|||....||||||.||.|.|:||||..|||||||.:|
Mouse  1859 AWVDPEDPHKGFRYLYLTPQDYTQISSQNSVHCKHIEDEGESRYVIVDVIGKDANLGVENLRGSG 1923

  Fly  1933 LIAGETSQAYEEIVTIAMVTCRTIGIGSYVVRLGQRVIQIDNSHIILTGYAALNKLLGRKVYASN 1997
            :||||.|.|||:.|||:|||||.:|||:|:|||||||||::||||||||..||||:|||:||.||
Mouse  1924 MIAGEASLAYEKTVTISMVTCRALGIGAYLVRLGQRVIQVENSHIILTGAGALNKVLGREVYTSN 1988

  Fly  1998 NQLGGTQIMFNNGVTHKTEAIDLDGVYTILDWLSYIPAYIGCDLPIVLPNDRIERPVDFMPTKSP 2062
            |||||.|||..|||:|.|...|.:||.|||:|||:||......:||..|:|.|:|.::|.|||:|
Mouse  1989 NQLGGVQIMHTNGVSHVTVPDDFEGVCTILEWLSFIPKDNRSPVPITTPSDPIDREIEFTPTKAP 2053

  Fly  2063 YDPRWMLGGRVNPVNANDWENGFFDRDSWSEIMASWAKTVVTGRARLGGVPVGVIAVETRTVEVE 2127
            |||||||.||.:|.....|::||||..|:.||||.||:|||||||||||:||||||||||||||.
Mouse  2054 YDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVA 2118

  Fly  2128 MPADPANLDSEAKTLQQAGQVWYPDSSYKTAQAIKDFGREELPLIVFANWRGFSGGMKDMYEQIV 2192
            :||||||||||||.:|||||||:|||:|||||.|:||.:|.|||::|||||||||||||||||::
Mouse  2119 VPADPANLDSEAKIIQQAGQVWFPDSAYKTAQVIRDFNKERLPLMIFANWRGFSGGMKDMYEQML 2183

  Fly  2193 KFGAYIVDGLREYKKPVLIYLPPNAELRGGAWAVLDSLINPRYMETYADPEARGGVLEPEGIVEI 2257
            |||||||||||.|::|:|||:||.||||||:|.||||.|||..:|.|||.|:|||||||||.|||
Mouse  2184 KFGAYIVDGLRLYEQPILIYIPPCAELRGGSWVVLDSTINPLCIEMYADKESRGGVLEPEGTVEI 2248

  Fly  2258 KYKEKDLVKTIHRLDPTTIALKKELDEANASGDKVRAAQVDEKIKARIAVLMHVYHTVAVHFADL 2322
            |:::|||||||.|:||....|..:|.:|... ||.| .:::.::|||..:|:.:||.|||.||||
Mouse  2249 KFRKKDLVKTIRRIDPVCKKLVGQLGKAQLP-DKDR-KELEGQLKAREELLLPIYHQVAVQFADL 2311

  Fly  2323 HDTPERMLEKECISEIVPWRDSRRWLYWRLRRLLLEDAYIKKILRAQDNLSVGQAKQMLRRWLVE 2387
            ||||..||||..||:::.|:.:|.:.||||||||||....::||||...|:....:.|||||.||
Mouse  2312 HDTPGHMLEKGIISDVLEWKTARTFFYWRLRRLLLEAQVKQEILRASPELNHEHTQSMLRRWFVE 2376

  Fly  2388 EKGATEAYLWDKNEEMVSWYEEQINAE----SIVSRNVNSVRRDAIISTISKMLEDCPDVALDAV 2448
            .:||.:|||||.|:.:|.|.|:..:|:    |.:..|:|.::||:::.||..::::.|:|.:|.|
Mouse  2377 TEGAVKAYLWDSNQVVVQWLEQHWSAKDGLRSTIRENINYLKRDSVLKTIQSLVQEHPEVIMDCV 2441

  Fly  2449 VGLCQGLTPVNRGVVVRTLA 2468
            ..|.|.|||..|..|.:.|:
Mouse  2442 AYLSQHLTPAERIQVAQLLS 2461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACC	NP_610342.1	PccA	260..764	CDD:443802	398/509 (78%)
		biotinyl_domain	891..952	CDD:133459	37/60 (62%)
		ACC_central	956..1700	CDD:462429	430/773 (56%)
		Carboxyl_trans	1800..2342	CDD:426008	350/541 (65%)
Acacb	NP_001390456.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..145		14/96 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..213		12/60 (20%)
		PccA	250..776	CDD:443802	409/525 (78%)
		Biotin_lipoyl	885..951	CDD:395290	37/65 (57%)
		ACC_central	952..1699	CDD:462429	430/773 (56%)
		Carboxyltransferase. /evidence=ECO:0000255|PROSITE-ProRule:PRU01138	1706..2356		410/663 (62%)
		Carboxyl_trans	1791..2345	CDD:426008	358/555 (65%)