DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN4 and COPS4

DIOPT Version :9

Sequence 1:	NP_001163080.1	Gene:	CSN4 / 35759	FlyBaseID:	FBgn0027054	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001317656.1	Gene:	COPS4 / 51138	HGNCID:	16702	Length:	420	Species:	Homo sapiens

Alignment Length:	391	Identity:	268/391 - (68%)
Similarity:	317/391 - (81%)	Gaps:	6/391 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILN 74
            ||:|..|..|:|.:|:|||.|.||||:|:..:..:|.|.::.|:.||||:|||:||||||||:|.
Human     3 AAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLT 67

  Fly    75 DVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPL 139
            |..:.|..|||..:|.:.||||||:.|||||||||||.||.|||:|||:.:.||:||.|||||||
Human    68 DFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPL 132

  Fly   140 ETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDY 204
            |||||||:|:.||.||||||||||||:|.||||.:||||||||.|:.:|:||:.|||||||||||
Human   133 ETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDY 197

  Fly   205 RRKFIEAAQRYNELSYRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYG 269
            ||||||||||||||||:.||.:.||:.|||.||.||:||||||||||||||||||||||.|.|||
Human   198 RRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYG 262

  Fly   270 ILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGAL 334
            |||||||:||||.::||||.|:|..||||.|:||||||||||.||||||||||||||||||||||
Human   263 ILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGAL 327

  Fly   335 LDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFE----NRELLPQWDRQIQSLCYQVNSIIEKI 395
            |:|||.|||||||||||||||||.||||..|||||    ::.:...|...:..:  .:|.||:.:
Human   328 LEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETSGNHQSIFCLWIYLVWIV--HINGIIQYV 390

  Fly   396 S 396
            :
Human   391 T 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN4	NP_001163080.1	RPN5	<95..384	CDD:227403	222/292 (76%)
CSN4	NP_001163080.1	PCI	271..369	CDD:279707	81/97 (84%)
COPS4	NP_001317656.1	RPN5	<71..374	CDD:227403	228/302 (75%)
COPS4	NP_001317656.1	PCI	264..362	CDD:279707	81/97 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146035
Domainoid	1	1.000	363	1.000	Domainoid score	I949
eggNOG	1	0.900	-	-		E1_KOG1497
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8067
Inparanoid	1	1.050	563	1.000	Inparanoid score	I1085
Isobase	1	0.950	-	0	Normalized mean entropy	S2157
OMA	1	1.010	-	-		QHG54346
OrthoDB	1	1.010	-	-		D457777at33208
OrthoFinder	1	1.000	-	-		FOG0005728
OrthoInspector	1	1.000	-	-		oto89270
orthoMCL	1	0.900	-	-		OOG6_103354
Panther	1	1.100	-	-	LDO	PTHR10855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2466
SonicParanoid	1	1.000	-	-		X4718
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750