DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CSN4 and Cops4

DIOPT Version :9

Sequence 1:	NP_001163080.1	Gene:	CSN4 / 35759	FlyBaseID:	FBgn0027054	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001004275.1	Gene:	Cops4 / 360915	RGDID:	1302952	Length:	406	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	285/393 - (72%)
Similarity:	330/393 - (83%)	Gaps:	0/393 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AALRSQLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILN 74
            ||:|..|..|:|.:|:|||.|.||||:|:..:..:|.|.::.|:.||||:|||:||||||||:|.
  Rat     3 AAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLT 67

  Fly    75 DVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPL 139
            |..:.|..|||..:|.:.|||||||.|||||||||||.||..||:|||:.:.||:||.|||||||
  Rat    68 DFCTHLPNLPDSTAKEVYHFTLEKVQPRVISFEEQVASIRQRLASIYEKEEDWRNAAQVLVGIPL 132

  Fly   140 ETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDY 204
            |||||||:|:.||.||||||||||||:|.||||.:||||||||.|:.:|:||:.|||||||||||
  Rat   133 ETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDY 197

  Fly   205 RRKFIEAAQRYNELSYRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYG 269
            ||||||||||||||||:.||.:.||:.|||.||.||:||||||||||||||||||||||.|.|||
  Rat   198 RRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYG 262

  Fly   270 ILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGAL 334
            |||||||:||||.::||||.|:|..||||.|:||||||||||.||||||||||||||||||||||
  Rat   263 ILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGAL 327

  Fly   335 LDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFENRELLPQWDRQIQSLCYQVNSIIEKISVAE 399
            |:|||.|||||||||||||||||.||||..|||||.||.||.||:||||||:|||:::||||...
  Rat   328 LEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTA 392

  Fly   400 PDW 402
            |:|
  Rat   393 PEW 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN4	NP_001163080.1	RPN5	<95..384	CDD:227403	230/288 (80%)
CSN4	NP_001163080.1	PCI	271..369	CDD:279707	81/97 (84%)
Cops4	NP_001004275.1	RPN5	<71..377	CDD:227403	237/305 (78%)
		PCI	264..362	CDD:396121	81/97 (84%)
		CSN4_RPN5_eIF3a	365..406	CDD:375846	20/31 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339774
Domainoid	1	1.000	360	1.000	Domainoid score	I931
eggNOG	1	0.900	-	-		E1_KOG1497
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8067
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1054
OMA	1	1.010	-	-		QHG54346
OrthoDB	1	1.010	-	-		D457777at33208
OrthoFinder	1	1.000	-	-		FOG0005728
OrthoInspector	1	1.000	-	-		oto96393
orthoMCL	1	0.900	-	-		OOG6_103354
Panther	1	1.100	-	-	LDO	PTHR10855
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4718
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770