DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8726 and MDM1

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_013603.1	Gene:	MDM1 / 854867	SGDID:	S000004572	Length:	1127	Species:	Saccharomyces cerevisiae

Alignment Length:	712	Identity:	121/712 - (16%)
Similarity:	223/712 - (31%)	Gaps:	277/712 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPI---------DDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLR 67
            |||         |..:|:..::|..:..:.:.:..:.|   ..||||           ::.|||.
Yeast   152 LPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAV---EFNKNY-----------KIHKSLS 202

  Fly    68 V------SGIELPLPRKRIFGNMRPEFIAERKQAL------QEYINAVLMNPILASSLPAKRFVD 120
            :      ..||..: ||.:.|.:...|..:...:|      .|.:...:::|::.      :|.|
Yeast   203 LKPNALQKEIEKSI-RKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIF------KFTD 260

  Fly   121 PESY-------SQSFHD--HAVQNAMLCL----------RNDTTWSLGGSMGAIGWRLR------ 160
            |:|:       ||::.:  |.|......|          .||......|...:....|.
Yeast   261 PDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGK 325

  Fly   161 --KHY-----------------FKVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHSIDA 206
              :||                 :.:..|..:...|:.|.|...: ::.:...:.:...|..|...
Yeast   326 QFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLK-YKKRLLLSLNLIESKLSFPG 389

  Fly   207 GTLDPGSEVVAEWLEYGPDKFIDE----KEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKF 267
            ..:|..|:.:|....| ||..:|.    ||:...:.|:
Yeast   390 SEIDTASKKLAREANY-PDLNMDNGIVLKEMASFLTSI--------------------------- 426

  Fly   268 HKHGTLKDVL-----------CMAANPK---NTFL------SKYGNP----------KGRTALSM 302
                ||||::           .:.:.|:   :|||      ..:.||          .|.:.:|.
Yeast   427 ----TLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGIST 487

  Fly   303 KQVATYG------------KQILEAL---IFLHSKGYAYGH-------LHSGNIVIVDDCVKLLD 345
            .|:....            |.:.|.|   |.|....:...:       .....:::..:.:|.||
Yeast   488 MQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLD 552

  Fly   346 IENFLLGVPAFYR-PFFMQH-SKIHAIETIDVYCFGHVLFEM-AMGYPLQESVVRQ--------- 398
             :.||   |.|.: |.|::. |..|.|.| |:|  .|.|..: .:..|.|..:::.
Yeast   553 -DRFL---PLFKKTPSFLKMLSTSHIIST-DIY--AHFLSRIGGVNNPEQNKIIKDNVKTDFMNP 610

  Fly   399 --------ITECPEALKCLLESILSKEACK------AGLPTLEQLLG------------------ 431
                    ||:.       |::|::....|      :..|...||.|
Yeast   611 VRIFANPGITDA-------LDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDN 668

  Fly   432 ------------HRFFLQYASTESAGAAANAEKPYFKLSLNAKELLKQAAIKSENRLRDE----- 479
                        |...::..|..|..:..|..:.|                 ..|..||.
Yeast   669 TSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFY-----------------GSNNFRDNIASLT 716

  Fly   480 ------QKSVKNQKRIVRVQELMSSEEEKR--KSKQKAKLEHKQSK--LKQQSSIQTNNGRL 531
                  :|.::..:.::...:|.:::.:.:  |..|:..|:..:.|  ||||..:|.|...|
Yeast   717 ISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSL 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	28/148 (19%)
CG8726	NP_610341.2	PKc	237..432	CDD:270622	47/302 (16%)
MDM1	NP_013603.1	PXA	85..276	CDD:214611	29/144 (20%)
		RGS	462..567	CDD:413378	19/108 (18%)
		PX_MDM1p	763..900	CDD:132786	7/16 (44%)
		Nexin_C	993..1106	CDD:400794
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900