DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8726 and SNX25

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001364961.1	Gene:	SNX25 / 83891	HGNCID:	21883	Length:	1037	Species:	Homo sapiens

Alignment Length:	440	Identity:	77/440 - (17%)
Similarity:	144/440 - (32%)	Gaps:	155/440 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DDTQALSC--EITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSL-----RVSGIE 72
            ::.:.|.|  .:.::|||.           |...|| |||.||.::|..|.:.|     .:..::
Human   719 ENGEQLPCYFVMVSLQEVG-----------GVETKN-WTVPRRLSEFQNLHRKLSECVPSLKKVQ 771

  Fly    73 LPLPRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPE-SYSQSFHDHAVQNA 136
            ||...|..|.::..:|:.:.|..|.:::..:|.:..|..|.....|:.|. .|.:.......:|:
Human   772 LPSLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQGKKNS 836

  Fly   137 MLCLRNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSG 201
            .             |:.:...||.:.:|                     :||.:.
Human   837 F-------------SLSSFLERLPRDFF---------------------SHQEEE---------- 857

  Fly   202 HSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRK 266
                       :|..::..:||.|  :|            |.:....||..:        |:...
Human   858 -----------TEEDSDLSDYGDD--VD------------GRKDALAEPCFM--------LIGEI 889

  Fly   267 FHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHS 331
            |...|..|.|                   .||.:::.|| |:|:.|.:.
Human   890 FELRGMFKWV-------------------RRTLIALVQV-TFGRTINKQ---------------- 918

  Fly   332 GNIVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVV 396
                 :.|.|..:..|..|:.....:|..|..:.|:....||            ......||:..
Human   919 -----IRDTVSWIFSEQMLVYYINIFRDAFWPNGKLAPPTTI------------RSKEQSQETKQ 966

  Fly   397 RQITECPEALKCLLESILSKEACKAGL----PTLEQLLGHRFFLQYASTE 442
            |...:..|.:..:|:|::.::..:.|:    ..|::...::..| ||..|
Human   967 RAQQKLLENIPDMLQSLVGQQNARHGIIKIFNALQETRANKHLL-YALME 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	29/124 (23%)
CG8726	NP_610341.2	PKc	237..432	CDD:270622	32/198 (16%)
SNX25	NP_001364961.1	PXA	166..321	CDD:396666
		235kDa-fam	<331..>691	CDD:130673
		RGS_SNX25	488..596	CDD:188675
		PX_SNX25	699..821	CDD:132788	27/113 (24%)
		Nexin_C	898..1004	CDD:400794	25/158 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900