Protein Alignment CG8726 and pxk

DIOPT Version :10

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001076277.1
• Gene: pxk / 557065
• ZFINID: ZDB-GENE-050208-393
• Length: 575
• Species: Danio rerio
• Alignment Length: 643
• Identity: 253/643 - (39%)
• Similarity: 347/643 - (53%)
• Gaps: 93/643 - (14%)

  Fly    10 RKLPIDDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLRVSGIELP 74
            ||.|:|||..||..|.|.|.:..||||::||.||.|..|.|||:|||:|||.|:.||.:||:.||
Zfish    14 RKPPLDDTVPLSAVIEASQSLQSHTEYIIRVQRGVSTDNSWTVIRRYSDFDMLNNSLLISGLNLP 78

  Fly    75 LPRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHDHAVQNAMLC 139
            ||.|::.|||..||||||::.||.|:|.:..:.||.|....|:|:|..:||.::.:.|:|...:.
Zfish    79 LPPKKLLGNMDREFIAERQKGLQAYLNYITQHHILCSCELVKKFLDTNNYSANYTEIALQQVSMF 143

  Fly   140 LRNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHSI 204
            .|:|..|.:...:..|||||||.||              |||...|
Zfish   144 FRSDPKWEVIEPLKDIGWRLRKRYF--------------LVKDKDQ------------------- 175

  Fly   205 DAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKFHK 269
                  |..:.|..|::.|||||:.:|::...||.|..|.|.:|.||..|..:|:..|:||.|.:
Zfish   176 ------PKEKQVLSWVDLGPDKFLSDKDLQSAMKLLPTLSHSNISPVSFATTSESSALIIRVFSE 234

  Fly   270 HGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGNI 334
            .|||:|.:| ...||..||.||.|||....|.::|:.|:|:||||||.|||.||:.|||||:.|:
Zfish   235 KGTLRDHIC-KVKPKEPFLRKYCNPKKIQGLELQQIRTFGRQILEALKFLHDKGFPYGHLHASNV 298

  Fly   335 VIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQI 399
            :|.::..||||:||.|||:|::|||:..|..||:..|:||||.|||:|:||..|.| .::|  .:
Zfish   299 LIEENTCKLLDVENSLLGLPSYYRPYVTQFRKINTTESIDVYSFGHLLYEMTYGRP-PDAV--PV 360

  Fly   400 TECPEA----LKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLSLN 460
            .:||.|    :..:|:||||.||||.|:||:.|||....|...       ...|:|||.||:|..
Zfish   361 DQCPPAPFSSIVSVLQSILSTEACKTGMPTVSQLLQTPLFYDV-------LLFNSEKPQFKISSK 418

  Fly   461 AKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQS--KLKQQSS 523
            .||.||.:....|.||.:||:::...||:.|.|....|||||||.|..|:.:.:||  ::::..|
Zfish   419 LKEALKSSKEGLEKRLVEEQRTIHQHKRLTRAQSHHGSEEEKRKRKILARKKSRQSTYEIEEDLS 483

  Fly   524 IQTNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPPLTPGPHLGSIY 588
            ::.||.      :..:.|||..|     |           |..||.|.| ...||.|.|
Zfish   484 VKYNNN------SAGSGASSPPT-----C-----------PSSPTPLPG-SGAPLPPPP------ 519

  Fly   589 QQELPSTTGAPVERQSSTPNMLSEDAEGGDGDEPTRSALLESICKFNRGSLRKVRSND 646
                |.....|.....|.|..||..:..|.|    |.|||.||..|::..|:|..:.|
Zfish   520 ----PPPPPPPPPGIDSGPPSLSPPSANGVG----RGALLSSIQSFSKNKLKKAETVD 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	59/118 (50%)
		Protein Kinases, catalytic domain	237..432	CDD:473864	98/198 (49%)
		WH2	622..646	CDD:425359	9/23 (39%)
pxk	NP_001076277.1	PX_MONaKA	17..136	CDD:132781	59/118 (50%)
		Protein Kinases, catalytic domain	202..349	CDD:473864	75/147 (51%)
		WH2_DdVASP-like	543..573	CDD:409205	12/31 (39%)
		actin-binding sequence	562..565	CDD:409205	1/2 (50%)