DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8726 and KIF16B

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_005260807.1	Gene:	KIF16B / 55614	HGNCID:	15869	Length:	1883	Species:	Homo sapiens

Alignment Length:	476	Identity:	87/476 - (18%)
Similarity:	171/476 - (35%)	Gaps:	139/476 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 IGGIMKS----LMGLQHPHIEPVLLAAHTENGCLVIRKFHKHGTLKDVLC--MAANPKNTFLSKY 291
            ||.::.|    |:|:....:...::..|.:.|...:.: ....|.:|::.  :....::......
Human   445 IGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGR-DDASTEQDIVLHGLDLESEHCIFENI 508

  Fly   292 GNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGNIVIV-----------DDCVKLLD 345
            |.......||..|.:..|.||:||.           ||:.|.::::           .:..||.:
Human   509 GGTVTLIPLSGSQCSVNGVQIVEAT-----------HLNQGAVILLGRTNMFRFNHPKEAAKLRE 562

  Fly   346 ------IENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQ---------ESV 395
                  :.:|.|.:....:    ....:.|:          :|:...: :|::         |..
Human   563 KRKSGLLSSFSLSMTDLSK----SRENLSAV----------MLYNPGL-FPIKGPICLRLEFERQ 612

  Fly   396 VRQITECPEALKCLLESILSKE-ACKAGLPTLEQ-LLGHRFFLQYASTESAGAAANAEKPYFKLS 458
            .|:..|..|:.:.|:|.:..|: :.||.|..::| :...|...:....:......:.::..|.:.
Human   613 QREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIE 677

  Fly   459 LNAKELLKQAAIKSENRLRDEQKSVKNQKR------------IVRVQELMSSEE----------- 500
            ...|:||.:.....|.|||::|:....:||            :.|::||.::|:
Human   678 NKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELD 742

  Fly   501 --EKRKSKQKAKLEHKQSKLKQQSSIQTNNGRLSLVAATAAAASSSTTVV-----GELCGTDSFN 558
              :|.|.:|.||||.::.:|::|...|     :.|||...........::     ||:...:
Human   743 QLQKEKDEQYAKLELEKKRLEEQEKEQ-----VMLVAHLEEQLREKQEMIQLLRRGEVQWVE--- 799

  Fly   559 RSDSTPEEPTTLAGIKSPPLTPGPHLGSIYQQELPSTTGAPVERQSSTPNMLSEDAEGG--DGDE 621
                  ||...|.||:...|                              .:.|...||  ||:|
Human   800 ------EEKRDLEGIRESLL------------------------------RVKEARAGGDEDGEE 828

  Fly   622 PTRSALLESICKFNRGSLRKV 642
            ..::.|  ...:|.|..|.|:
Human   829 LEKAQL--RFFEFKRRQLVKL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781
CG8726	NP_610341.2	PKc	237..432	CDD:270622	37/228 (16%)
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816
		KISc	3..365	CDD:214526
		Kinesin_assoc	364..476	CDD:292801	6/30 (20%)
		FHA	478..543	CDD:278899	14/76 (18%)
		TPH	610..934	CDD:290579	59/284 (21%)
		GBP_C	<618..818	CDD:303769	46/243 (19%)
		coiled coil	808..818	CDD:293879	2/39 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900