Protein Alignment CG8726 and PXK

DIOPT Version :10

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001336421.1
• Gene: PXK / 54899
• HGNCID: 23326
• Length: 581
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 217/568 - (38%)
• Similarity: 316/568 - (55%)
• Gaps: 71/568 - (12%)

  Fly    11 KLPIDDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLRVSGIELPL 75
            |:.:|||..|:..|.|.|.:..||||::||.||.|.:|.|.::|||:|||.|:.||:::|:.|||
Human    11 KVLLDDTVPLTAAIEASQSLQSHTEYIIRVQRGISVENSWQIVRRYSDFDLLNNSLQIAGLSLPL 75

  Fly    76 PRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHDHAVQNAMLCL 140
            |.|::.|||..||||||::.||.|:|.:..|.||::....|:|:||.:||.::.:.|:|...:..
Human    76 PPKKLIGNMDREFIAERQKGLQNYLNVITTNHILSNCELVKKFLDPNNYSANYTEIALQQVSMFF 140

  Fly   141 RNDTTWSLGGSMGAIGWRLRKHYF--KVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHS 203
            |::..|.:...:..||||:||.||  |:..:|.|:
Human   141 RSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKER------------------------------ 175

  Fly   204 IDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKFH 268
                       :|..|.:.||||::.:|:...::|.|....||:|..|..|...|:..|:||.|:
Human   176 -----------LVLSWADLGPDKYLSDKDFQCLIKLLPSCLHPYIYRVTFATANESSALLIRMFN 229

  Fly   269 KHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGN 333
            :.||||| |...|.||:.||.||.|||....|.::|:.|||:||||.|.|||.||:.|||||:.|
Human   230 EKGTLKD-LIYKAKPKDPFLKKYCNPKKIQGLELQQIKTYGRQILEVLKFLHDKGFPYGHLHASN 293

  Fly   334 IVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQ 398
            :::..|..:|||:||.|||:|:|||.:|.|..||:.:|::||:||||:|:||..|.|.....|..
Human   294 VMLDGDTCRLLDLENSLLGLPSFYRSYFSQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDS 358

  Fly   399 ITECPE-ALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLSLNAK 462
            ....|. |:..:|||.||.||||.|:||:.:||....|.....|.|       |||.||:....|
Human   359 FPPAPSMAVVAVLESTLSCEACKNGMPTISRLLQMPLFSDVLLTTS-------EKPQFKIPTKLK 416

  Fly   463 ELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSKLK--QQSSIQ 525
            |.|:.|....|.||.:|||.:...:|:.|.|....||||::|.|..|:.:.|:|.|:  ::.|.:
Human   417 EALRIAKECIEKRLIEEQKQIHQHRRLTRAQSHHGSEEERKKRKILARKKSKRSALENSEEHSAK 481

  Fly   526 TNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGI 573
            .:|...|    ..:.|||..|             |.|:|..|:|.|.:
Human   482 YSNSNNS----AGSGASSPLT-------------SPSSPTPPSTSAAL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	55/118 (47%)
		Protein Kinases, catalytic domain	237..432	CDD:473864	95/195 (49%)
		WH2	622..646	CDD:425359
PXK	NP_001336421.1	PX_MONaKA	13..132	CDD:132781	55/118 (47%)
		Protein Kinases, catalytic domain	198..345	CDD:473864	74/147 (50%)