DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8726 and Slob

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001260212.1	Gene:	Slob / 34038	FlyBaseID:	FBgn0264087	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	162/725 - (22%)
Similarity:	254/725 - (35%)	Gaps:	210/725 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LLRVWRGASNKNYWTVLRRYN---DFDRLD-KSLRVSG----IELPLPRKRIFGNMRPEFIAERK 93
            ::||...||.|..:|:. ::|   ...|:| ::..|:|    :..|:|.|::...|:.   ..:.
  Fly   109 IVRVCEVASAKKSFTMF-KFNKAAQQQRIDNRNSAVTGHDPFVRPPVPEKKVRNIMKK---LHKA 169

  Fly    94 QALQEYINAVLMNPILASSLPAKR----FVDPE-SYSQSFHDHAVQNAML------------CLR 141
            ..|:...:|:..:   .|:|.|..    :..|. .|..|..|..  |.::            .|.
  Fly   170 NGLKRSNSAIEFD---VSALTAANRRQIYSRPNIKYQYSALDSG--NGIVERSPRERAQREKALN 229

  Fly   142 NDTTWSLGGS--------MGAIGWRLRKHYFKVTTK-------------PPEKSSNKQLVKSGSQ 185
            ....|..|.:        :..||.|..|::|.||..             ||:..:.:.|
  Fly   230 ATQEWIQGANGRYEVIAHLDEIGSRHGKNWFLVTDASVRTDRLQTLLPLPPDCVAFEDL------ 288

  Fly   186 THQSKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMG-LQHPHIE 249
                                     |.:|...|                 |:..|:| |.||:|.
  Fly   289 -------------------------PPNECARE-----------------ILMELLGSLHHPYIY 311

  Fly   250 PVLLAAHTEN-----GCLVIRKFHKHGTLKDVLCMAANPKNTFLSKY-GNPKGRTALSMKQVATY 308
            |||......|     .||| ..|:..|:||| |...|.....:..|| ..|.|   |.:.||...
  Fly   312 PVLDLGFLRNSSYNYACLV-TPFNSRGSLKD-LIYKAQWNEPWARKYTRKPNG---LPVSQVQRL 371

  Fly   309 GKQILEALIFLHSKGY-AYGHLHSGNIVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIET 372
            |:||||||:||..:|: .:|||||||:::.:...:|..:||.|||:.:.........| :..||.
  Fly   372 GRQILEALLFLKERGFPLHGHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWSRS-VTEIEN 435

  Fly   373 IDVYCFGHVLFEMAMG-------------------YPLQESVVRQITECPEALKCLLESILSKEA 418
            :|:.||||:|:||..|                   ||       ||.:..|.|..:.|.  ....
  Fly   436 VDIVCFGHLLYEMCTGQELTTPKPSMRVLEMELQHYP-------QIGQILEILGLIFEP--PSGV 491

  Fly   419 CKAGLPTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLS-LNAKELLKQAAIKSENRLRDEQK- 481
            |    |::|.|:....|......|..|...:..||....| ||..:.:|:....|......|..
  Fly   492 C----PSVEDLVLCDLFRSIDLRELRGPCFSTIKPSLSRSTLNLLQAVKKRQCASLGHSLSEANS 552

  Fly   482 -----SVKNQKRIVRVQELMSSEEEKRKSKQKAKLE-------HKQSKLKQQSSIQTNNGRLSLV 534
                 |..:.:| ..:...|.|.:....|::....|       |:|..|:    :|..:...|.|
  Fly   553 PCTPPSTPHDRR-TGISRTMDSFDISSDSEEGLLEEIVVGGSCHRQHLLR----LQQWHSAHSYV 612

  Fly   535 AATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPP-----LTPGPHLGSIYQQELPS 594
            .:.|:.:.........:...|:.......|:.||......|..     |..|. ...:|:::  .
  Fly   613 HSYASESPIHYCDPAAVYSDDNSQEPGQDPQPPTIRCSTSSQSNLDVLLAEGA-ADEVYEEQ--E 674

  Fly   595 TTGAPVERQSSTPNMLSEDAEGGDGDEP------TRSA--------LLESICKFNRGSLRKV--- 642
            ..|...|          |:|.|..|.:.      |.||        |...:|.:.....|::
  Fly   675 EEGFEQE----------EEASGSSGTQRLQAPACTSSAAGASFNHQLTADMCNYKNSKSRRLEYS 729

  Fly   643 -------RSN 645
                   |||
  Fly   730 LKCLKYGRSN 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	24/107 (22%)
CG8726	NP_610341.2	PKc	237..432	CDD:270622	73/221 (33%)
Slob	NP_001260212.1	PKc	286..481	CDD:270622	72/255 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6221
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D477171at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22999
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970