Protein Alignment CG8726 and Slob

DIOPT Version :10

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001260212.1
• Gene: Slob / 34038
• FlyBaseID: FBgn0264087
• Length: 1347
• Species: Drosophila melanogaster
• Alignment Length: 726
• Identity: 162/726 - (22%)
• Similarity: 256/726 - (35%)
• Gaps: 212/726 - (29%)

  Fly    37 LLRVWRGASNKNYWTVLRRYN---DFDRLD-KSLRVSG----IELPLPRKRIFGNMRPEFIAERK 93
            ::||...||.|..:|:. ::|   ...|:| ::..|:|    :..|:|.|::...|:.   ..:.
  Fly   109 IVRVCEVASAKKSFTMF-KFNKAAQQQRIDNRNSAVTGHDPFVRPPVPEKKVRNIMKK---LHKA 169

  Fly    94 QALQEYINAVLMNPILASSLPAKR----FVDPE-SYSQSFHDHAVQNAML------------CLR 141
            ..|:...:|:..:   .|:|.|..    :..|. .|..|..|..  |.::            .|.
  Fly   170 NGLKRSNSAIEFD---VSALTAANRRQIYSRPNIKYQYSALDSG--NGIVERSPRERAQREKALN 229

  Fly   142 NDTTWSLGGS--------MGAIGWRLRKHYFKVTTK-------------PPEKSSNKQLVKSGSQ 185
            ....|..|.:        :..||.|..|::|.||..             ||:..:.:.|
  Fly   230 ATQEWIQGANGRYEVIAHLDEIGSRHGKNWFLVTDASVRTDRLQTLLPLPPDCVAFEDL------ 288

  Fly   186 THQSKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMG-LQHPHIE 249
                                     |.:|...|                 |:..|:| |.||:|.
  Fly   289 -------------------------PPNECARE-----------------ILMELLGSLHHPYIY 311

  Fly   250 PVLLAAHTEN-----GCLVIRKFHKHGTLKDVLCMAANPKNTFLSKY-GNPKGRTALSMKQVATY 308
            |||......|     .||| ..|:..|:||| |...|.....:..|| ..|.|   |.:.||...
  Fly   312 PVLDLGFLRNSSYNYACLV-TPFNSRGSLKD-LIYKAQWNEPWARKYTRKPNG---LPVSQVQRL 371

  Fly   309 GKQILEALIFLHSKGY-AYGHLHSGNIVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIET 372
            |:||||||:||..:|: .:|||||||:::.:...:|..:||.|||:.:.........| :..||.
  Fly   372 GRQILEALLFLKERGFPLHGHLHSGNVILQNGAARLSGLENGLLGLSSRINAVMWSRS-VTEIEN 435

  Fly   373 IDVYCFGHVLFEMAMG-------------------YPLQESVVRQITECPEALKCLLESILSKEA 418
            :|:.||||:|:||..|                   ||       ||.:..|.|..:.|.
  Fly   436 VDIVCFGHLLYEMCTGQELTTPKPSMRVLEMELQHYP-------QIGQILEILGLIFEP------ 487

  Fly   419 CKAGL-PTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLS-LNAKELLKQAAIKSENRLRDEQK 481
             .:|: |::|.|:....|......|..|...:..||....| ||..:.:|:....|......|..
  Fly   488 -PSGVCPSVEDLVLCDLFRSIDLRELRGPCFSTIKPSLSRSTLNLLQAVKKRQCASLGHSLSEAN 551

  Fly   482 ------SVKNQKRIVRVQELMSSEEEKRKSKQKAKLE-------HKQSKLKQQSSIQTNNGRLSL 533
                  |..:.:| ..:...|.|.:....|::....|       |:|..|:    :|..:...|.
  Fly   552 SPCTPPSTPHDRR-TGISRTMDSFDISSDSEEGLLEEIVVGGSCHRQHLLR----LQQWHSAHSY 611

  Fly   534 VAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPP-----LTPGPHLGSIYQQELP 593
            |.:.|:.:.........:...|:.......|:.||......|..     |..|. ...:|:::
  Fly   612 VHSYASESPIHYCDPAAVYSDDNSQEPGQDPQPPTIRCSTSSQSNLDVLLAEGA-ADEVYEEQ-- 673

  Fly   594 STTGAPVERQSSTPNMLSEDAEGGDGDEP------TRSA--------LLESICKFNRGSLRKV-- 642
            ...|...|          |:|.|..|.:.      |.||        |...:|.:.....|::
  Fly   674 EEEGFEQE----------EEASGSSGTQRLQAPACTSSAAGASFNHQLTADMCNYKNSKSRRLEY 728

  Fly   643 --------RSN 645
                    |||
  Fly   729 SLKCLKYGRSN 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	24/107 (22%)
		Protein Kinases, catalytic domain	237..432	CDD:473864	73/222 (33%)
		WH2	622..646	CDD:425359	9/48 (19%)
Slob	NP_001260212.1	Protein Kinases, catalytic domain	286..481	CDD:473864	72/255 (28%)