DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8726 and Rps6kc1

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_848890.3	Gene:	Rps6kc1 / 320119	MGIID:	2443419	Length:	1056	Species:	Mus musculus

Alignment Length:	713	Identity:	133/713 - (18%)
Similarity:	237/713 - (33%)	Gaps:	219/713 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GHTEYLLRVWRGASNKN--------YWTVLRRYNDFDRLDKSL--------RVSGIELPLPRKRI 80
            |:|.|.:.. |..|.:|        .|   |||:||.:|.:.|        |.|.:..|..:..:
Mouse    26 GYTVYKVTA-RVVSRRNPEDVQEIIVW---RRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTV 86

  Fly    81 FGNMRPEFIAERKQALQEYINAVLMNPILASSL-------------------PAKRFVDPESYSQ 126
            ||......|.||:|..::.:......|.|.:|.                   ||:.:  |:|.:.
Mouse    87 FGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAY--PDSPAN 149

  Fly   127 SFHDHAVQNAMLCLRNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQ--- 188
            :|.:        |             |..|:........:|......:.    |..|..:.|
Mouse   150 AFPE--------C-------------GTEGFSSDSDLLSLTVDADSLAE----VDDGMASRQGSP 189

  Fly   189 SKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGI----MKSLMGLQHPHIE 249
            |:.|....|..|.   ..|.:...||         |.: ::::|...:    :|..:| :..::|
Mouse   190 SRTFGLSLSTDSS---AVGAVASDSE---------PSR-VEDRESRSLFPSSLKPRLG-RRDYLE 240

  Fly   250 ------PVLLAAHTENGCLVIRKFHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATY 308
                  .:.|....|:.......|::.|.  |:|......::       :|..|.|:. ::.|.|
Mouse   241 KAGELIKLALKKEEEDDYEAASDFYRKGV--DLLLEGVQGES-------SPTRREAVK-RRTAEY 295

  Fly   309 ---GKQI--LEALIFLHSKGYAYGHLHSGN----------------IVIVDDCVKLLDI---ENF 349
               .:.|  |.|...||:.....|.|.|..                :.::|..:.::|.   :.|
Mouse   296 LMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTF 360

  Fly   350 LLG---------------VPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQI 399
            :|.               :|.........|:.|.:.|::      .::.:.|.|..|...:.:.:
Mouse   361 ILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESV------FLVLQRAEGGKLWSYISKFL 419

  Fly   400 TECPEALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAA----NAEKPYFKLSLN 460
            ....:      ||:..||    |.|::..    |..||..|....|.::    .::......:|.
Mouse   420 NRSSQ------ESLDIKE----GRPSMPP----RVCLQQPSASPQGGSSFESRGSDTGSMLKALP 470

  Fly   461 AKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSK-----LKQ 520
            .|..|..::....|:..|.|.|....     :....|||:|..........|:.|.|     |.:
Mouse   471 LKTSLTPSSQDDSNQEDDGQPSSPKW-----LDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSE 530

  Fly   521 QSSIQTNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPPLTPGPHLG 585
            :|.:|....:    |.|.|.:|.::...|.: ...:..|..|..|:   |..:.|||.:
Mouse   531 ESVMQPEGDK----ADTQAVSSPASLATGSV-SPSTHLRVFSGGED---LEAVSSPPTS------ 581

  Fly   586 SIYQQELPSTTGAPVE-----RQSSTPNMLSED------------------AEGGDGDEPTRS 625
                :.|..:..:|:|     .:.||..:|..|                  .|  |||.|::|
Mouse   582 ----ESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLE--DGDSPSQS 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	31/134 (23%)
CG8726	NP_610341.2	PKc	237..432	CDD:270622	39/239 (16%)
Rps6kc1	NP_848890.3	PX_RPK118_like	11..128	CDD:132820	26/105 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..223		5/28 (18%)
		MIT_SNX15	237..309	CDD:239140	15/81 (19%)
		PKc_like	334..>427	CDD:304357	12/104 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..504		18/90 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..588		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..662		6/13 (46%)
		S_TKc	<864..1046	CDD:214567
		STKc_RPK118_like	<869..1046	CDD:270728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900