Protein Alignment CG8726 and Rps6kc1

DIOPT Version :10

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_848890.3
• Gene: Rps6kc1 / 320119
• MGIID: 2443419
• Length: 1056
• Species: Mus musculus
• Alignment Length: 713
• Identity: 133/713 - (18%)
• Similarity: 237/713 - (33%)
• Gaps: 219/713 - (30%)

  Fly    32 GHTEYLLRVWRGASNKN--------YWTVLRRYNDFDRLDKSL--------RVSGIELPLPRKRI 80
            |:|.|.:.. |..|.:|        .|   |||:||.:|.:.|        |.|.:..|..:..:
Mouse    26 GYTVYKVTA-RVVSRRNPEDVQEIIVW---RRYSDFKKLHRELWQIHRNAFRHSELFPPFAKGTV 86

  Fly    81 FGNMRPEFIAERKQALQEYINAVLMNPILASSL-------------------PAKRFVDPESYSQ 126
            ||......|.||:|..::.:......|.|.:|.                   ||:.:  |:|.:.
Mouse    87 FGRFDKTVIEERRQCAEDLLQFSANIPALYNSRQLQDFFKGGVISDGSELIGPAEAY--PDSPAN 149

  Fly   127 SFHDHAVQNAMLCLRNDTTWSLGGSMGAIGWRLRKHYFKVTTKPPEKSSNKQLVKSGSQTHQ--- 188
            :|.:        |             |..|:........:|......:.    |..|..:.|
Mouse   150 AFPE--------C-------------GTEGFSSDSDLLSLTVDADSLAE----VDDGMASRQGSP 189

  Fly   189 SKHFAAGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGI----MKSLMGLQHPHIE 249
            |:.|....|..|.   ..|.:...||         |.: ::::|...:    :|..:| :..::|
Mouse   190 SRTFGLSLSTDSS---AVGAVASDSE---------PSR-VEDRESRSLFPSSLKPRLG-RRDYLE 240

  Fly   250 ------PVLLAAHTENGCLVIRKFHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATY 308
                  .:.|....|:.......|::.|.  |:|......::       :|..|.|:. ::.|.|
Mouse   241 KAGELIKLALKKEEEDDYEAASDFYRKGV--DLLLEGVQGES-------SPTRREAVK-RRTAEY 295

  Fly   309 ---GKQI--LEALIFLHSKGYAYGHLHSGN----------------IVIVDDCVKLLDI---ENF 349
               .:.|  |.|...||:.....|.|.|..                :.::|..:.::|.   :.|
Mouse   296 LMRAESICSLRAAPQLHTGPQPPGSLSSRPPWSLRSPAEELKAFRVLGVIDKVLLVMDTRTEQTF 360

  Fly   350 LLG---------------VPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQI 399
            :|.               :|.........|:.|.:.|::      .::.:.|.|..|...:.:.:
Mouse   361 ILKGLRKSSECSRNRKTIIPRCVPNMVCLHTYIISEESV------FLVLQRAEGGKLWSYISKFL 419

  Fly   400 TECPEALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAA----NAEKPYFKLSLN 460
            ....:      ||:..||    |.|::..    |..||..|....|.::    .::......:|.
Mouse   420 NRSSQ------ESLDIKE----GRPSMPP----RVCLQQPSASPQGGSSFESRGSDTGSMLKALP 470

  Fly   461 AKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSK-----LKQ 520
            .|..|..::....|:..|.|.|....     :....|||:|..........|:.|.|     |.:
Mouse   471 LKTSLTPSSQDDSNQEDDGQPSSPKW-----LDSGSSSEDECTAGYLTLCNEYGQEKMDLVSLSE 530

  Fly   521 QSSIQTNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKSPPLTPGPHLG 585
            :|.:|....:    |.|.|.:|.::...|.: ...:..|..|..|:   |..:.|||.:
Mouse   531 ESVMQPEGDK----ADTQAVSSPASLATGSV-SPSTHLRVFSGGED---LEAVSSPPTS------ 581

  Fly   586 SIYQQELPSTTGAPVE-----RQSSTPNMLSED------------------AEGGDGDEPTRS 625
                :.|..:..:|:|     .:.||..:|..|                  .|  |||.|::|
Mouse   582 ----ESLSRSKNSPMEFFRIDSKDSTSELLGLDFGEKLHSLKPEPLKALFTLE--DGDSPSQS 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	31/134 (23%)
		Protein Kinases, catalytic domain	237..432	CDD:473864	39/239 (16%)
		WH2	622..646	CDD:425359	2/4 (50%)
Rps6kc1	NP_848890.3	PX_RPK118_like	11..128	CDD:132820	26/105 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..223		5/28 (18%)
		MIT_SNX15	237..309	CDD:239140	15/81 (19%)
		Protein Kinases, catalytic domain	334..>427	CDD:473864	12/104 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..504		18/90 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..588		15/76 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..662		6/13 (46%)
		STKc_RPK118_like	<869..1046	CDD:270728