DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8726 and Pxk

DIOPT Version :9

Sequence 1:	NP_610341.2	Gene:	CG8726 / 35758	FlyBaseID:	FBgn0033244	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_038949349.1	Gene:	Pxk / 306203	RGDID:	727819	Length:	581	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	212/578 - (36%)
Similarity:	319/578 - (55%)	Gaps:	72/578 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVFASRYERKLPIDDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKS 65
            ||.......||:.:|||..|:..:.|.|.:..||||::||.||.|.:|.|.::|||:|||.|:.|
  Rat     1 MAFMEKPPARKVLLDDTVPLTAAVEASQSLQSHTEYIIRVQRGISAENSWQIVRRYSDFDLLNNS 65

  Fly    66 LRVSGIELPLPRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHD 130
            |:::|:.||||.|::.|||..||||||::.||.|:|.::.|.:|::....|:|:||.:||.::.:
  Rat    66 LQITGLSLPLPPKKLIGNMDREFIAERQKGLQNYLNVIMANHVLSNCELLKKFLDPNNYSANYTE 130

  Fly   131 HAVQNAMLCLRNDTTWSLGGSMGAIGWRLRKHYF--KVTTKPPEKSSNKQLVKSGSQTHQSKHFA 193
            .|:|...:..|::..|.:...:..||||:||.||  |:..:|.|:
  Rat   131 IALQQVSMFFRSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKER-------------------- 175

  Fly   194 AGSSNGSGHSIDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTE 258
                                 :|..|.:.||||::.:|:...::|.|....||:|..|..|..:|
  Rat   176 ---------------------LVLSWADLGPDKYLSDKDFQCLIKLLPSCVHPYIYRVTFATASE 219

  Fly   259 NGCLVIRKFHKHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKG 323
            :..|:||.|:..||||| |...|.||:.||.||.|||....|.::|:.|||:||||.|.|||.||
  Rat   220 SSALLIRTFNDKGTLKD-LIYKAKPKDPFLKKYCNPKKTQGLELQQIKTYGRQILEVLKFLHDKG 283

  Fly   324 YAYGHLHSGNIVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMG 388
            :.|||||:.|:::..:..:|||:||.|||:|:|||.:|.|..||:.:|::||:||||:|:||..|
  Rat   284 FPYGHLHAANVMLDGNTCRLLDLENSLLGLPSFYRSYFTQFRKINTLESVDVHCFGHLLYEMTYG 348

  Fly   389 YPLQESVVRQITECPE-ALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAANAEK 452
            .|.....|........ |:..:|||.||.||||.|:||:.:||....|.....|.|       ||
  Rat   349 RPPDSVPVDSFPPASSMAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTS-------EK 406

  Fly   453 PYFKLSLNAKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSK 517
            |.||:....:|.|:.|....|.||.:|||.:...:|:.|.|....||||:::.|..|:.:.|:|.
  Rat   407 PQFKIPTKLREALRIAKECIEKRLTEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSA 471

  Fly   518 LK--QQSSIQTNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGI 573
            ::  ::..::.:|...|     .:.|||..|             |.|:|..|:|.|.:
  Rat   472 VENSEEQPVKHSNANNS-----GSGASSPLT-------------SPSSPTPPSTAAAL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	53/118 (45%)
CG8726	NP_610341.2	PKc	237..432	CDD:270622	93/195 (48%)
Pxk	XP_038949349.1	PX_MONaKA	13..132	CDD:132781	53/118 (45%)
Pxk	XP_038949349.1	PKc_like	198..345	CDD:419665	73/147 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352886
Domainoid	1	1.000	129	1.000	Domainoid score	I5150
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9828
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1961
OMA	1	1.010	-	-		QHG52386
OrthoDB	1	1.010	-	-		D477171at33208
OrthoFinder	1	1.000	-	-		FOG0008393
OrthoInspector	1	1.000	-	-		oto96389
orthoMCL	1	0.900	-	-		OOG6_107735
Panther	1	1.100	-	-	LDO	PTHR22999
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6382
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810