Protein Alignment CG8726 and Pxk

DIOPT Version :9

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_663433.2
• Gene: Pxk / 218699
• MGIID: 1289230
• Length: 582
• Species: Mus musculus
• Alignment Length: 648
• Identity: 237/648 - (36%)
• Similarity: 350/648 - (54%)
• Gaps: 95/648 - (14%)

  Fly    11 KLPIDDTQALSCEITAVQEVAGHTEYLLRVWRGASNKNYWTVLRRYNDFDRLDKSLRVSGIELPL 75
            |:.:|||..|:..:.|.|.:..||||::||.||.|.:|.|.::|||:|||.|:.||:::|:.|||
Mouse    11 KVLLDDTVPLTAAVEASQSLQSHTEYIIRVQRGISAENSWQIVRRYSDFDLLNNSLQITGLSLPL 75

  Fly    76 PRKRIFGNMRPEFIAERKQALQEYINAVLMNPILASSLPAKRFVDPESYSQSFHDHAVQNAMLCL 140
            |.|::.|||..||||||::.||.|:|.::.|.:|::....|:|:||.:||.::.:.|:|...:..
Mouse    76 PPKKLIGNMDREFIAERQRGLQNYLNVIMANHVLSNCELLKKFLDPNNYSANYTEIALQQVSMFF 140

  Fly   141 RNDTTWSLGGSMGAIGWRLRKHYF--KVTTKPPEKSSNKQLVKSGSQTHQSKHFAAGSSNGSGHS 203
            |::..|.:...:..||||:||.||  |:..:|.|:
Mouse   141 RSEPKWEVVEPLKDIGWRIRKKYFLMKIKNQPKER------------------------------ 175

  Fly   204 IDAGTLDPGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKFH 268
                       :|..|.:.||||::.:|:...::|.|....||:|..|..|..:|:..|:||.|:
Mouse   176 -----------LVLSWADLGPDKYLSDKDFQCLIKLLPSCVHPYIYRVTFATASESSALLIRAFN 229

  Fly   269 KHGTLKDVLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGN 333
            :.||||| |...|.||:.||.||.|||....|.::|:.|||:||||||.|||.||:.|||||:.|
Mouse   230 EKGTLKD-LIYKAKPKDPFLKKYCNPKKTQGLELQQIKTYGRQILEALKFLHDKGFPYGHLHAAN 293

  Fly   334 IVIVDDCVKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQ 398
            :::..:..:|||:||.|||:|:|||.:|.|..||:.:|::||:||||:|:||..|.|.....|..
Mouse   294 VMLDGNTCRLLDLENSLLGLPSFYRSYFTQFRKINTLESVDVHCFGHLLYEMTYGRPPDSVPVDS 358

  Fly   399 ITECPE-ALKCLLESILSKEACKAGLPTLEQLLGHRFFLQYASTESAGAAANAEKPYFKLSLNAK 462
            ...... |:..:|||.||.||||.|:||:.:||....|.....|.|       |||.||:....|
Mouse   359 FPPASSLAVVAVLESTLSCEACKNGMPTVSRLLQMPLFSDVLLTTS-------EKPQFKIPTKLK 416

  Fly   463 ELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQSKLK--QQSSIQ 525
            |.|:.|....|.||.:|||.:...:|:.|.|....||||:::.|..|:.:.|:|.::  ::..::
Mouse   417 EALRIAKECIEKRLTEEQKQIHQHRRLTRAQSHHGSEEERKRRKILARKKSKRSAVENSEEQPVK 481

  Fly   526 TNNGRLSLVAATAAAASSSTTVVGELCGTDSFNRSDSTPEEPTTLAGIKS-------PPLTPGPH 583
            .:|...|    ..:.|||..|             |.|:|..|:| ||:.|       ||..|.|.
Mouse   482 HSNSNNS----AGSGASSPLT-------------SPSSPTPPST-AGLSSALPPPPPPPPPPPPP 528

  Fly   584 LGSIYQQELPSTTGAPVERQSSTPNMLSEDAEGGDGDEPTRSALLESICKFNRGSLRKVRSND 646
            .|       ||.|.|   .:...| .|.:...|     ..|.|||.||..|.:|:|||.::.|
Mouse   529 AG-------PSPTSA---TEMPAP-FLPQPVNG-----VNRGALLSSIQNFQKGTLRKAQTCD 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	53/118 (45%)
		PKc	237..432	CDD:270622	94/195 (48%)
Pxk	NP_663433.2	PX_MONaKA	13..132	CDD:132781	53/118 (45%)
		PKc	198..345	CDD:270622	74/147 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..550		39/145 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849268
Domainoid	1	1.000	105	1.000	Domainoid score	I6668
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9828
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2006
Isobase	1	0.950	-	0	Normalized mean entropy	S6221
OMA	1	1.010	-	-		QHG52386
OrthoDB	1	1.010	-	-		D477171at33208
OrthoFinder	1	1.000	-	-		FOG0008393
OrthoInspector	1	1.000	-	-		oto92835
orthoMCL	1	0.900	-	-		OOG6_107735
Panther	1	1.100	-	-	LDO	PTHR22999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5226
SonicParanoid	1	1.000	-	-		X6382
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750