Protein Alignment CG8726 and nish-1

DIOPT Version :9

• Sequence 1: NP_610341.2
• Gene: CG8726 / 35758
• FlyBaseID: FBgn0033244
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_502016.2
• Gene: nish-1 / 177981
• WormBaseID: WBGene00008750
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 531
• Identity: 110/531 - (20%)
• Similarity: 198/531 - (37%)
• Gaps: 139/531 - (26%)

  Fly    50 WTVLRRYNDFDRLDKSLRVSGIELPLPRKRIFGNMRPEFIAERKQALQEYINAVLMNPIL----- 109
            |||.|||:|||..|....:...:..||.|:..||...|||.||:..|::|:.|:|...:.
 Worm    46 WTVERRYSDFDAYDVHRFLDRKKSFLPPKKRLGNKDLEFIEERRLELEKYVRALLELEVWYQKQK 110

  Fly   110 -ASSLP--AKRFVDPESYSQSFHDHAVQNAMLCLRNDTTWSLGGSMGAIGW----RLRKHYFKVT 167
             ..|||  ..:|.|       ||.:.:.:.:    :|.:..| |::|. ||    :....||:.|
 Worm   111 NVHSLPLITAKFFD-------FHQYEIHSIV----DDLSLRL-GNLGD-GWLESSQTSPKYFEFT 162

  Fly   168 ----------TKPPEKSS-NKQLVKSGSQTHQSKHFA-----------AGSSNGSGHSIDAGTLD 210
                      .:.||.:: :..:|.....|....|..           .|:||...:|:|. :|.
 Worm   163 PIELHAITERLRLPEPTAPDVNMVADIGNTIDFLHRVRALKIRGQKGYVGTSNIVWNSLDM-SLY 226

  Fly   211 PGSEVVAEWLEYGPDKFIDEKEIGGIMKSLMGLQHPHIEPVLLAAHTENGCLVIRKFHKHGTLKD 275
            ....:.|.|:...     |...|.|| ||:..                    .:|:...|.::|.
 Worm   227 FCKGLKALWIADS-----DVCRINGI-KSIRE--------------------TLRRLVVHYSMKK 265

  Fly   276 VLCMAANPKNTFLSKYGNPKGRTALSMKQVATYGKQILEALIFLHSKGYAYGHLHSGNIVIVDDC 340
            :..:..:.::.          .|.:.::::.|:  :.||.:           .|....|...|:.
 Worm   266 IKDLLFDEEDL----------ETGMLVEEMDTW--KCLEEV-----------DLSFNEIKCFDES 307

  Fly   341 VKLLDIENFLLGVPAFYRPFFMQHSKIHAIETIDVYCFGHVLFEMAMGYPLQESVVRQITECPEA 405
            :|||. |..:|.|         .::.|..|.:  ...|...|.|:    .|..:.:.:|....|.
 Worm   308 MKLLP-EVRVLNV---------SYNSITEIGS--NLAFLSSLTEL----DLSNNTLTKIDGWNEK 356

  Fly   406 LKCLLESILSKEACKAGLPTLEQL--LGHRFFLQYA-----------STESAGAAANAE------ 451
            |..:.:.|||:.|       :|.|  ||..:.|:|.           :.:..|.....|
 Worm   357 LGNIKKLILSENA-------IEDLSGLGKLYSLEYLDAKGNNIQNLDAVQGIGKLPCLEILLLRD 414

  Fly   452 KPYFKLSLNAKELLKQAAIKSENRLRDEQKSVKNQKRIVRVQELMSSEEEKRKSKQKAKLEHKQS 516
            .|..||.....::|:....:|.....|.::....:...|||:..:...:|:::.::|.:.|..:.
 Worm   415 NPIRKLVEYRTKVLELFGERSSELKLDGRRPEARELDTVRVRMALRKAKEEKEEREKKRRERIEE 479

  Fly   517 KLKQQSSIQTN 527
            :::..|....|
 Worm   480 RIRYISGEDVN 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8726	NP_610341.2	PX_MONaKA	13..132	CDD:132781	31/89 (35%)
		PKc	237..432	CDD:270622	34/196 (17%)
nish-1	NP_502016.2	PX_domain	18..137	CDD:383026	31/101 (31%)
		LRR	<289..423	CDD:227223	35/167 (21%)
		leucine-rich repeat	291..313	CDD:275380	8/33 (24%)
		leucine-rich repeat	314..336	CDD:275380	5/32 (16%)
		leucine-rich repeat	337..359	CDD:275380	6/25 (24%)
		leucine-rich repeat	360..381	CDD:275380	8/27 (30%)
		leucine-rich repeat	382..406	CDD:275380	3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900