DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nito and RBM4

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_002887.2	Gene:	RBM4 / 5936	HGNCID:	9901	Length:	364	Species:	Homo sapiens

Alignment Length:	382	Identity:	84/382 - (21%)
Similarity:	138/382 - (36%)	Gaps:	104/382 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRA-----KIELS 375
            ||.|||.....:.|:|.:|.:||.|.:.||.:       .:.||..::...|..|     ..:|.
Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDIIK-------NYGFVHIEDKTAAEDAIRNLHHYKLH 61

  Fly   376 GQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETV 440
            |..|.....|   .|...:|::.:|.:....:..:|..:|:.:|.:  ||....:.||::..|..
Human    62 GVNINVEASK---NKSKTSTKLHVGNISPTCTNKELRAKFEEYGPV--IECDIVKDYAFVHMERA 121

  Fly   441 EAATAAVKEMRGFPLGGPE-------RRLRTDFAELPG-ATPAAPFKSSKP-------PYDESA- 489
            |.|..|::.:......|..       .||||    .|| ...:..::..|.       |.|.|.
Human   122 EDAVEAIRGLDNTEFQGKRMHVQLSTSRLRT----APGMGDQSGCYRCGKEGHWSKECPIDRSGR 182

  Fly   490 ----LEYRRPEY----DPY---YEESA----AYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHY- 538
                .|....:|    .||   |.:|.    ||.....|  |......|...........:|:|
Human   183 VADLTEQYNEQYGAVRTPYTMSYGDSLYYNNAYGALDAY--YKRCRAARSYEAVAAAAASVYNYA 245

  Fly   539 HNDVHRPPHPGSLAG----SSSSVPPPGGVEDEWRRPPGESYDR------GARSSSREPGVERS- 592
            ...:.:.|...:.|.    :|:|:.|               |||      ||.:::.......:
Human   246 EQTLSQLPQVQNTAMASHLTSTSLDP---------------YDRHLLPTSGAAATAAAAAAAAAA 295

  Fly   593 ----------RSRSPLKRARSP----------GSDSDTSTRRNDALASASTVPDVAR 629
                      |.||||:||.:|          |.:|:.|   ..:.|:.:::.|:||
Human   296 VTAASTSYYGRDRSPLRRATAPVPTVGEGYGYGHESELS---QASAAARNSLYDMAR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	21/78 (27%)
		RRM3_Spen	397..467	CDD:240756	17/76 (22%)
		SPOC	630..789	CDD:311609	84/382 (22%)
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	20/70 (29%)
		RRM2_RBM4	78..144	CDD:410019	14/67 (21%)
		PTZ00368	<145..>181	CDD:173561	9/39 (23%)
		ZnF_C2HC	161..176	CDD:197667	1/14 (7%)
		Interaction with TNPO3. /evidence=ECO:0000269\|PubMed:12628928	196..364		36/174 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910