DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and rbm4.2

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_955971.1	Gene:	rbm4.2 / 557528	ZFINID:	ZDB-GENE-030131-3019	Length:	385	Species:	Danio rerio

Alignment Length:	398	Identity:	90/398 - (22%)
Similarity:	137/398 - (34%)	Gaps:	138/398 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRA-----KIELS 375
            :|.|||..|...|:||.:|.::|:|.:.|:.:       .:.||...:...|..|     ..||.
Zfish     4 IFIGNLSPTSTADDLRSLFSEFGIVKECDVLK-------NYGFVHMDSKKEAEAAIRKLHHYELK 61

  Fly   376 GQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETV 440
            ||.|   ..::..||...:|::.:..:.:..:..:|..:|:.:|.:.:.:..|  .||::..|.:
Zfish    62 GQAI---NVELSKGKPRGSTKLHVSNISSGCTNQELRAKFEEYGPVVECDIVK--DYAFVHMERM 121

  Fly   441 EAATAAV--------------------------------------------KEMR---------- 451
            :.|..|:                                            |:.|
Zfish   122 DDAMEAISGLENTTFQGKLIKVQLSTSRLRTAPGMGDQTGCYICGEQGHWSKDCRHSQNGSYGGG 186

  Fly   452 --GFPLGGPERRLRTDFAELPGATPAAPFKSS--KPPYDESALEYRRPEYDPYYEESAAYAPRGG 512
              |:|..||.|...:.....||..|:..:.:.  .||...|    |||.|..|..|     ||..
Zfish   187 MGGYPSRGPPRGGPSYGMGGPGGHPSRGYPAGPLPPPPPMS----RRPSYGEYGAE-----PRER 242

  Fly   513 Y-----SPYPPRGGY--RGRGG-------YRGRGRGMYHYHNDVHR---PPHPGSLAGSSSS--- 557
            |     :.||.|...  |.|.|       :|.......:|.:..|.   ||.|..|:.||.|
Zfish   243 YLTRVPTGYPERPPVYERDRFGSIDYYEKFRAHPAASSYYEDRPHAIPPPPPPPPLSSSSLSRMR 307

  Fly   558 VPPPGGVEDEWRRP----------------------------PGESYDRGARSSSREPGVERSRS 594
            :.|| .::...|||                            .|.||:|     ||...|.||.|
Zfish   308 LAPP-SLDPYERRPLAPPPPTAAAAASFARDRSPIRRVGAGAEGYSYER-----SRLSPVSRSSS 366

  Fly   595 RSPLKRAR 602
            ...|.|||
Zfish   367 AYSLPRAR 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	21/78 (27%)
		RRM3_Spen	397..467	CDD:240756	16/125 (13%)
		SPOC	630..789	CDD:311609
rbm4.2	NP_955971.1	RRM1_2_CoAA_like	3..68	CDD:240789	21/73 (29%)
		RRM_SF	78..144	CDD:302621	10/67 (15%)
		ZnF_C2HC	161..177	CDD:197667	1/15 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910