Protein Alignment nito and RAVER2

DIOPT Version :10

• Sequence 1: NP_610339.1
• Gene: nito / 35756
• FlyBaseID: FBgn0027548
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_001353094.1
• Gene: RAVER2 / 55225
• HGNCID: 25577
• Length: 691
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 128/745 - (17%)
• Similarity: 209/745 - (28%)
• Gaps: 285/745 - (38%)

  Fly   201 SRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDY---------------RPLHHDYPHPP 250
            |.:.:|.|..|..:.|..:.::  |.|...|.|:||.:.               :.|..:.|...
Human    18 SAAGLGPGPGLRGQGPSAEAHE--GAPDPMPAALHPEEVAARLQRMQRELSNRRKILVKNLPQDS 80

  Fly   251 RGPPLH-----------------RGGHPHHLHGHAPP------HQYAPMRPLAPRPHAPYEKPES 292
            ....:|                 |......|:|....      |||                  |
Human    81 NCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAIQMFHQY------------------S 127

  Fly   293 KKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKR------PPPG 351
            .:.|  :.:..:||.|     ..|...|:.::...:|...:...||     :|:|      ...|
Human   128 FRGK--DLIVQLQPTD-----ALLCITNVPISFTSEEFEELVRAYG-----NIERCFLVYSEVTG 180

  Fly   352 TGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREF- 415
            ....:.||.|...|.|.:|::||.|:.:|             |:.::    ..|..|..|..|.
Human   181 HSKGYGFVEYMKKDFAAKARLELLGRQLG-------------ASALF----AQWMDVNLLASELI 228

  Fly   416 -DRFGAIKKI--EYQKGEP--------------------------YAYIQYETVEAATAAVKEMR 451
             .:...|.|:  :|:..|.                          :|.::|.|.|.|....:...
Human   229 HSKCLCIDKLPSDYRDSEELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYSTAEQAEEVQQAAD 293

  Fly   452 GFPLGGPERRL---------RTDFAE---------------LPGATPAAPFKSSKPP-------- 484
            |..:.|.:.::         |:..|.               ||...|....||...|
Human   294 GMTIKGSKVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQ 358

  Fly   485 --------------YDESALEYRRPEYDP-------------------YYEESAAYAP------- 509
                          ...|......|...|                   .:.::.::.|
Human   359 PQLCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVMGNTSNLFLQNLSHIPLAQQQLM 423

  Fly   510 ---------RGGYSPYPPRGGYR---GRGGYRGRGRGMYHYHNDVHR------------------ 544
                     :.|....||....:   |.|......:.:.|:|.:.|:
Human   424 KFENIHTNNKPGLLGEPPAVVLQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTTITAGMGML 488

  Fly   545 PPHPGS-LAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREP---------------GVERSR 593
            |..|.. :||.:.    ||....:.::|.......|..|.| :|               |..:.:
Human   489 PFFPNQHIAGQAG----PGHSNTQEKQPATVGMAEGNFSGS-QPYLQSFPNLAAGSLLVGHHKQQ 548

  Fly   594 SRSPLKRARSPGSDSDTST------------RRNDALASASTVPDVARKCSTVWTGALILKSSLF 646
            ...|.....|.|:.|...|            .:|..|..||.:|.|.            |.|...
Human   549 QSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVC------------LSSPAS 601

  Fly   647 PAKFHLTDGDTDIVESLMRDEEGKHNLRITQRLRLDPPKLDDVQ-------KRIASSSSHAIFMG 704
            ....|.|...:.|::::.:..|.:|.|.  :.:...||..|..|       ||   .||:.|...
Human   602 KTTLHKTGIASSILDAISQGSESQHALE--KCIAYSPPFGDYAQVSSLRNEKR---GSSYLISAP 661

  Fly   705 LAGSTNDTNCDDASVQTRPLRNLVSYLKQK 734
            ..||   ..|.|...|......:.:|||:|
Human   662 EGGS---VECVDQHSQGTGAYYMETYLKKK 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_610339.1	RRM1_Spen	98..175	CDD:409749
		RRM2_Spen	312..390	CDD:240755	18/83 (22%)
		RRM3_Spen	397..468	CDD:409750	16/109 (15%)
		SPOC_RBM15-like	634..790	CDD:439207	26/108 (24%)
RAVER2	NP_001353094.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		7/30 (23%)
		RRM1_RAVER2	70..139	CDD:410065	11/88 (13%)
		RRM2_RAVER2	143..219	CDD:410067	20/97 (21%)
		RRM3_RAVER2	229..326	CDD:410069	13/96 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..522		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..574		6/30 (20%)