DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and spen

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_003201252.2	Gene:	spen / 503940	ZFINID:	ZDB-GENE-050309-70	Length:	3476	Species:	Danio rerio

Alignment Length:	930	Identity:	201/930 - (21%)
Similarity:	320/930 - (34%)	Gaps:	318/930 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSHRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERM 66
            ||........|:..:.....||.|.| |..||||   :|.|:.....:||| ..||....|
Zfish   295 SSQSHNPSPQRLQSQAARPARSRSGS-GSRSRSS---SSDSVSSTSSSGSG-SSDSSSTSS---- 350

  Fly    67 RRRLDRSPSR------YGSPHREPYMRGPPPAERPAGYKV--LCVSALPPKAPDDFIEETLYREY 123
                ||||:|      ..:|..:|.    |..::....|.  :.|..||.::.|..:::.|:.|:
Zfish   351 ----DRSPARSVQSTAVPAPSTQPL----PSLDKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEF 407

  Fly   124 KKFGDF-SVRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRG 187
            ||.|.. ||::....:||...|.||..||..:|
Zfish   408 KKHGKVTSVQIHGASEERYGLVFFRQQEDQEKA-------------------------------- 440

  Fly   188 HSMSPPDYERYHYSRSPMGQGVPLD----HRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPH 248
                      ...|:..:..|:.:|    |                .|......::|||
Zfish   441 ----------LSASKGKLFFGMQIDVTAWH----------------GPETESENEFRPL------ 473

  Fly   249 PPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLST 313
                                                      :.:.|:|           .|.:|
Zfish   474 ------------------------------------------DERIDEF-----------HPKAT 485

  Fly   314 RTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGN-AFAFVRYQNLDMAHRAKIELSGQ 377
            ||||.||||.|...::|..||.::|.:.|||||:.   .|: .:||::|.::....:|..::.|:
Zfish   486 RTLFIGNLEKTTTYNDLLNIFQRFGEIVDIDIKKV---NGSPQYAFLQYCDIASVCKAIKKMDGE 547

  Fly   378 YIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEA 442
            |:|..:.|:|:||..|.|.:|:.||.:..:...|.|.|.|:|.:.|:.:.:.:..|.|.|..:|.
Zfish   548 YLGNNRLKLGFGKSMPTTCVWLDGLSSSITEQYLTRHFCRYGHVVKVVFDRLKGMALILYNNIEY 612

  Fly   443 ATAAVKEMRGFPLGGPERRLRTDFA----------ELPGA-------------------TPAAPF 478
            |.|||||.:|:.:||  .:::.|||          .:.|:                   ||...|
Zfish   613 AQAAVKETKGWKIGG--NKIKVDFANQESQMAFYRSMQGSGQDIRDFYEIISERRDERRTPYHEF 675

  Fly   479 KSSKPPYDE-----SALE-------------------YRRPEYDP-YYEESAAYAPRGGYSPYPP 518
            .:.:..|:.     |..|                   |:...||| ||::|..|  |....||..
Zfish   676 TAERAYYENVRTPTSYTEDPRRKYPARSREFFSEWDPYQGDYYDPRYYDDSREY--RDFRDPYEQ 738

  Fly   519 ---RGGYRGRGGYRGR------------GRGMYHYHNDVH---------------RPP------- 546
               :..|..|...|.|            .|.:.|..:..|               |||
Zfish   739 DIRKYSYLQRERERERERFETDRERDHGRRTIEHQQSPTHSRRPASPTASPSLSERPPSDSEHHV 803

  Fly   547 --HPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREP-----GVERSRSRSPLKRA--R 602
              .....:||.||:.||     .:.:|.....:|..|:...|.     ..||.......:||  :
Zfish   804 YSRSSERSGSCSSLSPP-----RFEKPDKIRLERHNRNDKLEKEKSLFETERGNGGEKERRAGRK 863

  Fly   603 SPGSDSDTSTRRNDALASAS-TVP----------DVARKCSTVWTGALILKSSLFPAKFHLTDGD 656
            ..|....|..::...|..|| |||          |.:.:.:....|.  :..||...|.:...|.
Zfish   864 EKGEKDRTERQKLKKLKLASPTVPSPEAELELDRDASPEANITLRGK--VSKSLIKDKDYSGKGK 926

  Fly   657 TDIVESL-----MRDEEGKHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCDD 716
            .|::..:     ::::|||          |....|.:.||....|..      :...|..::.|.
Zfish   927 LDLLPCVVQLTRVKEKEGK----------LIDSILCEKQKTKVGSDP------VLSPTTPSSGDH 975

  Fly   717 ASV------QTRPLRNLVSYLKQKEAAGVISLLNKETEATGVLYAFPPCDFSTELLKRTCHSL-- 773
            .|:      |.|.......:||:|..|..:.:::||.:.....|      |.::|...:..|:
Zfish   976 KSMPFRKDTQARDFFKHGKHLKEKGLASQVEVVDKEEKVKNKKY------FKSDLAFESSSSVDA 1034

  Fly   774 ----------TEEGLKEDHL 783
                      .|...|.|:|
Zfish  1035 DRKAARKRRFEETSAKADNL 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	35/179 (20%)
		RRM1_Spen	98..175	CDD:240754	20/79 (25%)
		RRM2_Spen	312..390	CDD:240755	29/78 (37%)
		RRM3_Spen	397..467	CDD:240756	23/69 (33%)
		SPOC	630..789	CDD:311609	33/177 (19%)
spen	XP_003201252.2	RRM1_SHARP	7..81	CDD:240794
		RRM2_SHARP	384..457	CDD:240795	22/114 (19%)
		RRM3_SHARP	484..557	CDD:240796	28/75 (37%)
		RRM4_SHARP	558..634	CDD:240797	26/77 (34%)
		FlgN	1159..>1221	CDD:298847
		Dicty_REP	<1879..>2032	CDD:252996
		SPOC	3321..3442	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820