DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and spen

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	166/756 - (21%)
Similarity:	262/756 - (34%)	Gaps:	263/756 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSHRDGAGADRITIKIHNMKRSASRSPGPAS--------RSSLSRNSRSMGRGYDNGSGVP---- 54
            |||...:.:       |:...|.:.||..:|        |||.:.||.::.....|.||..
  Fly   457 SSHSSSSSS-------HSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVS 514

  Fly    55 --------GDSPERLSPERMRRRLDRSPSRYGSP--------HREPYMRGPPPAERPAGYKVLCV 103
                    |.|....|          |.|..||.        |.|.        .||...:   |
  Fly   515 SAGVGGGCGSSSSSSS----------SSSSSGSSCLTANPVVHSED--------NRPLAIR---V 558

  Fly   104 SALPPKAPDDFIEETLYREYKKFGDFS-VRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDK 167
            ..||.::.|..:::.|:.||||.|..: |::.....||.|.|||:.|:|..:|..     :.:||
  Fly   559 RNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALE-----VSHDK 618

  Fly   168 MAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPH 232
                                           |:.      |..::     ::||..|.
  Fly   619 -------------------------------HFF------GCKIE-----VEPYQGYD------- 634

  Fly   233 AVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKF 297
             |...::||.                                                |::.|::
  Fly   635 -VEDNEFRPY------------------------------------------------EAELDEY 650

  Fly   298 PNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTG-NAFAFVRY 361
                       .|.||||||.||||..|...|||..|..:|.:.:||||:    .| ||:||.:|
  Fly   651 -----------HPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKK----QGLNAYAFCQY 700

  Fly   362 QNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEY 426
            .::....:|..::.|:::|..:.|:|:||..|...:||.|:....|.:.|:.:|.||||:.|:..
  Fly   701 SDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSI 765

  Fly   427 QKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFA--ELPGATPAAPFKSSKPPYDESA 489
            .:....|.:.|:.|:.|.||||:|||..|  ..::|:.|||  |...|.           ||:..
  Fly   766 DRNRQLALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAF-----------YDKQE 817

  Fly   490 LEYRR-----PEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPPHPG 549
            .:.::     |.:..|  ||:|.:.:.                 |.|......:.|:.:
  Fly   818 KQQQQSSGSNPRFSRY--ESSASSLQS-----------------RSRASSFSRHQNNSN------ 857

  Fly   550 SLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSPGSDSDTSTRR 614
               ...|.:..|||...                     |:.   |.|.|....:..:.|:..|..
  Fly   858 ---DDCSPINTPGGASS---------------------GIS---SASNLINQSTSINISNIGTNA 895

  Fly   615 NDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEG---KHNLRIT 676
            ..|:.:.|....|. .|:...:|.:       ||...:..|.:....||......   :|.:...
  Fly   896 CSAMPAPSLASAVV-SCNVNASGTV-------PASTSMPSGVSSSSSSLPMSPAALAQRHRMVRN 952

  Fly   677 QRLRLDPPKLDDVQKRIASSSSHAIFMGLAGST--NDTNCD 715
            .|..:| ...::| .|:...||..:..|...||  .|..||
  Fly   953 ARQTVD-CDFNEV-GRLRFRSSEEVSGGAGNSTQFEDVRCD 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	36/175 (21%)
		RRM1_Spen	98..175	CDD:240754	22/77 (29%)
		RRM2_Spen	312..390	CDD:240755	31/78 (40%)
		RRM3_Spen	397..467	CDD:240756	25/69 (36%)
		SPOC	630..789	CDD:311609	20/91 (22%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	24/122 (20%)
		RRM3_SHARP	654..726	CDD:240796	30/75 (40%)
		RRM4_SHARP	727..803	CDD:240797	27/77 (35%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23189
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850