DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nito and sfpq

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_998443.1	Gene:	sfpq / 406564	ZFINID:	ZDB-GENE-040426-2452	Length:	619	Species:	Danio rerio

Alignment Length:	500	Identity:	87/500 - (17%)
Similarity:	153/500 - (30%)	Gaps:	163/500 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRRRLDRSPSRYGSPHRE 83
            |...:..:...||....:.:...:.|.|....:...|.:|:: :|.....::..:|.:..||  .
Zfish    58 NQVSTQQKPQEPAQNKPVVQTPPAQGPGQAQQAANKGPTPQQ-TPTVAPPKIQSAPPKIQSP--P 119

  Fly    84 PYMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDFSVRLAHDLDERVAYVCFRT 148
            |.::.||||:..|                                                  :|
Zfish   120 PKIQSPPPAQNNA--------------------------------------------------KT 134

  Fly   149 PEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDH 213
            ||.|                                      ||.:.:|.:..:..||.|
Zfish   135 PEIA--------------------------------------SPQNQQRKNLPKPAMGNG----- 156

  Fly   214 RRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRP 278
            ::||                      .||..:....|..||..:...........|.::.:....
Zfish   157 QKPP----------------------APLKQEQTPAPTPPPAQQQQQQQQQQKQTPANEQSSQPQ 199

  Fly   279 LAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDI 343
            ......:...||..|     .|....:          ||.|||...|.:.|.|::|.|||...:|
Zfish   200 ELKATLSLLRKPGEK-----TYTQRCR----------LFIGNLPNDITEPEFRKLFAKYGEPSEI 249

  Fly   344 DIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSV 408
            .|.:     |..|.|:|.::..:|..||.||....:.....::.:  .|.:..:.:..|..:.|.
Zfish   250 FINQ-----GKGFGFIRLESRALAEVAKAELDDTPMKGRPLRVRF--ATHSAALSVRNLSPFVSN 307

  Fly   409 TQLEREFDRFGAIKK---IEYQKGEP--YAYIQYETVEAATAAVKEMRG--FPLGGPERRLRTDF 466
            ..||..|.:||.:::   |...:|..  ...:::.:..||..|:..:..  |.|....|.:..:.
Zfish   308 ELLEEAFSQFGLVERAIVIVDDRGRSTGKGIVEFSSKPAARKAMDRISDGVFLLTSSPRPIVVEL 372

  Fly   467 AELPGATPAAPFKSSKPPY-DESALEYRRPEYDPYYEESAAYAPR 510
            .|               .| ||..|..:..:.:|.|::.....||
Zfish   373 LE---------------QYDDEDGLPEKLAQKNPSYQKEREQPPR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	23/166 (14%)
		RRM1_Spen	98..175	CDD:240754	4/76 (5%)
		RRM2_Spen	312..390	CDD:240755	23/77 (30%)
		RRM3_Spen	397..467	CDD:240756	15/76 (20%)
		SPOC	630..789	CDD:311609
sfpq	NP_998443.1	RRM1_PSF	219..289	CDD:241031	23/84 (27%)
		RRM2_p54nrb_like	295..374	CDD:240779	15/78 (19%)
		eNOPS_SF	365..461	CDD:297912	9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930