DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and si:ch1073-335m2.2

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_005170404.1	Gene:	si:ch1073-335m2.2 / 322667	ZFINID:	ZDB-GENE-081104-82	Length:	3139	Species:	Danio rerio

Alignment Length:	823	Identity:	191/823 - (23%)
Similarity:	286/823 - (34%)	Gaps:	281/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 HNMKRSA-SRSPGPASRS-SLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRRRLDRSPSRYGSP 80
            |:.|||| |.|.||.||| |.|.:|.|:......||| ..|| ...|.|..|.|..:|.:.:..|
Zfish   262 HSPKRSALSPSRGPPSRSRSQSSSSDSVSSTSSTGSG-SSDS-NSSSSEGSRARSVQSTATHAPP 324

  Fly    81 HREPYMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDF-SVRLAHDLDERVAYV 144
            .............|..|.:   |..||.::.|..:::.|:.|:||:|.. ||::....:||...|
Zfish   325 ANTALTLDNDEPRRSFGIR---VQNLPTRSTDTSLKDGLFHEFKKYGKVTSVQIHGASEERYGLV 386

  Fly   145 CFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGV 209
            .||..||..:|.......:.:..:..|.                :.:.|:.|..:..|
Zfish   387 FFRQQEDQEKALSVSKGKLFFGMLIEVT----------------AWNGPETESENEFR------- 428

  Fly   210 PLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYA 274
            |||.|   ||.:             ||:
Zfish   429 PLDGR---IDEF-------------HPK------------------------------------- 440

  Fly   275 PMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGV 339
                                                 :|||||.||||.|....:|..:|.::|.
Zfish   441 -------------------------------------ATRTLFIGNLEKTTNYQQLLDVFQRFGE 468

  Fly   340 VDDIDIKR----PPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIG 400
            :.||||||    |      .:|||:|.::....:|..::.|:|:|..:.|:|:||..|...:|:.
Zfish   469 IVDIDIKRVNGVP------QYAFVQYSDIASVCKAIKKMDGEYLGTNRLKLGFGKSMPTACVWLD 527

  Fly   401 GLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTD 465
            ||.:..:...|.|.|.|:|.:.|:.:.:.:..|.:.|...:.|.|||:|.:|:.:||  .:::.|
Zfish   528 GLTSNITEQYLTRHFCRYGPVVKVVFDRLKGMALVLYNNTDFAQAAVRETKGWKIGG--NKIKVD 590

  Fly   466 FAELPGATPAAPFKSSKPP-------YD--ESALEYRRPEYDPYYEESAAY----APRGGYSPYP 517
            ||.  ..:..|.::|.:..       ||  ....:.||..|..:..|.|.|    .| |.|:..|
Zfish   591 FAS--QESQMAFYRSMQASGQDIRDFYDIPSDRRDERRTPYHDFPAERAYYENVRTP-GIYADDP 652

  Fly   518 PRGGYRGRGGYRGRGRGMY-------------HYHNDVHR------------------------- 544
                   |..|.||.|..|             .||.| ||
Zfish   653 -------RREYAGRSRERYTELDHYQGDHFDPRYHED-HREYRDYRDPFEAITKYSYIQRERERE 709

  Fly   545 --------------PPH----------------------------PGSLAGSSSSVPPPGGVEDE 567
                          |.|                            ....:||.||:.||....|:
Zfish   710 RERERFETDRGRWSPSHQRRALTPSASPSPSERVAREAERRVYRRSSERSGSCSSLSPPPAPFDK 774

  Fly   568 WRRPPGESYDRGAR------SSSREPGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVP- 625
            ..:.|.|....|..      ...|..|.|:.|.|...|..|..|.    .|::....|.:.::|
Zfish   775 PEKSPVEFKSEGLEREVEPSEGERVSGAEKKRGRRKEKAEREKGE----KTKQRRGRAQSPSIPL 835

  Fly   626 DVARKCSTVWTGALILK----SSLFPAKFHLTDGD-----TDIV----------------ESLMR 665
            ..|.|.:::..|:..||    .||...| |..|.:     ||.|                |||.|
Zfish   836 SEAEKEASLDLGSGKLKGSDVDSLERPK-HKADKEKEPSPTDHVIRLESQKGERLEQSKSESLDR 899

  Fly   666 DEEG--KHNLRIT-----QRLRLDPPKLDDVQKRIASSSSHAI 701
            |.:|  |.||:..     :...:|..:|:..::|....|..||
Zfish   900 DGKGKTKKNLKADSGSDGRDSLVDSDRLEARKRRFGDPSGKAI 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	39/167 (23%)
		RRM1_Spen	98..175	CDD:240754	20/77 (26%)
		RRM2_Spen	312..390	CDD:240755	30/81 (37%)
		RRM3_Spen	397..467	CDD:240756	20/69 (29%)
		SPOC	630..789	CDD:311609	27/104 (26%)
si:ch1073-335m2.2	XP_005170404.1	RRM1_SHARP	7..81	CDD:240794
		RRM2_SHARP	341..414	CDD:240795	20/75 (27%)
		RRM3_SHARP	441..514	CDD:240796	29/78 (37%)
		RRM4_SHARP	515..591	CDD:240797	22/77 (29%)
		Ehrlichia_rpt	1520..2098	CDD:118064
		SPOC	2984..3105	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820