DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nito and nono

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_963873.1	Gene:	nono / 321994	ZFINID:	ZDB-GENE-030131-713	Length:	441	Species:	Danio rerio

Alignment Length:	295	Identity:	61/295 - (20%)
Similarity:	98/295 - (33%)	Gaps:	80/295 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 RGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYE-KP----------ESKKDKFPN----- 299
            |||...:       ..|.|..|       .|.|....: ||          ::.:...||
Zfish     5 RGPRSEQ-------QNHGPQRQ-------QPNPQQEQQRKPTGADSNGQHTDAGEQSSPNAGFTI 55

  Fly   300 -YLHHVQPEDDPLSTRT-LFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQ 362
             ..:..:|.:...:.|: ||.|||.....::::.::|.|||...:|.|.:     ...|.|:|.:
Zfish    56 DLQNFKKPGEKTYTQRSRLFVGNLPAGTTEEDVEKLFSKYGKASEIFINK-----DRGFGFIRLE 115

  Fly   363 NLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQ 427
            ...:|..||.||........|.::.:  .|....:.:..|..:.|...||..|..||.|::
Zfish   116 TKTLADIAKAELDDTIFRGRQIRVRF--ATHGAALTVKNLPQFVSNELLEEAFSMFGPIER---- 174

  Fly   428 KGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAA-------------PFK 479
                            ...:.:.||.|.|    :...:||..|.|..|.             |..
Zfish   175 ----------------AIVIVDDRGRPTG----KGIVEFANKPSARKALDRCGDGAFLLTAFPRP 219

  Fly   480 SSKPPY----DESALEYRRPEYDPYYEESAAYAPR 510
            .:..|.    :|..|..|....:|.|.:.....||
Zfish   220 VTIEPMEQLDEEEGLPERLINKNPVYHKEREQPPR 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	21/78 (27%)
		RRM3_Spen	397..467	CDD:240756	12/69 (17%)
		SPOC	630..789	CDD:311609
nono	NP_963873.1	RRM_SF	71..141	CDD:302621	21/74 (28%)
		RRM2_p54nrb	147..226	CDD:241035	19/102 (19%)
		NOPS_p54nrb	217..310	CDD:240582	9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840