DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and Rbm15b

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_038938548.1	Gene:	Rbm15b / 315988	RGDID:	1305937	Length:	887	Species:	Rattus norvegicus

Alignment Length:	937	Identity:	316/937 - (33%)
Similarity:	423/937 - (45%)	Gaps:	269/937 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HRDGAGADRITIKIHNMKRSASRSPGPAS-RSSLSRNSRSMGRGYDNG--SGVP---GDSPERLS 62
            ||||                  |:.|.|: |:|..|:|.:.|.|...|  ||.|   |.|| |.|
  Rat    66 HRDG------------------RAAGDANHRASSGRSSGAPGGGGRTGKASGDPGAGGASP-RAS 111

  Fly    63 PERMRRRLDRSPSRYGSPHREPYMRGPPPAERPAG--------YKVLCVSALPPKAPDDFIEETL 119
            |      |...|              |||...|||        ||.|.:|:|.|..|.:.:|:.|
  Rat   112 P------LPPPP--------------PPPGAEPAGPGTTAAPEYKTLLISSLSPALPAEHLEDRL 156

  Fly   120 YREYKKFGDFSVRLAHDLD-ERVAYVCFRTPEDAREAKHH--KPRLIIYDKMAIVEPVYKSTTRP 181
            :.::|:||:.|:||:|..: .|||||.||.|:|||||:.|  ..:|::||:...|||||.
  Rat   157 FHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYL----- 216

  Fly   182 EYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDY 246
                ||...|      ...|.|......|     ||       ||    |....|..|.|||..|
  Rat   217 ----RGGGSS------RRSSSSSAAASTP-----PP-------GP----PTPADPLGYLPLHGGY 255

  Fly   247 PH------PPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYL---- 301
            .:      |...|||......|.....|.....|....|:......|......:.:..:|.
  Rat   256 QYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYSYQAVCE 320

  Fly   302 HHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDM 366
            ..:.||||..:||.||.|||:.::::.||||.|.|||:::::.||||..|.|.|:||:::|||||
  Rat   321 EDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDM 385

  Fly   367 AHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEP 431
            |||||:.:||:.||:...||||||..|.||:|:||||..||:..|.|||||||:|:.|::.||:.
  Rat   386 AHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDS 450

  Fly   432 YAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRP- 495
            :||||||:::||.||..:|||||||||:||||.|||:                    |.|.|.|
  Rat   451 FAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAK--------------------AEETRYPQ 495

  Fly   496 EYDPYYEESAAYAPRGGYSPYPPR-----GGY-RGR---GGYRGRGRGMYHYHNDVHRPPH---- 547
            :|.|              ||.|..     .|| |.|   ...|.|.|          .|||
  Rat   496 QYQP--------------SPLPVHYELLTDGYTRHRNLDADLRVRDR----------TPPHLLYS 536

  Fly   548 --------------------PGSLAGSSSSVPPPGGVE-------------DEWRRPPGESYDRG 579
                                ..||.|.|.||....|..             :|.|:....|.|||
  Rat   537 DRDRTFLEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGADGDRSIAKPWEERRKRRSLSSDRG 601

  Fly   580 --------------------ARSSSREPGVERSRSR------------SPLKRAR---------- 602
                                .|.|.|.|  ||||..            :.|..:|
  Rat   602 RTTHSPYEERSRTKGGGQQSERGSDRTP--ERSRKENHSSEGTKESGSNSLSNSRHSAEERSHHH 664

  Fly   603 ----SPGSDSDTSTR---RNDALASA---------------STVPDVARKCSTVWTGALILKSSL 645
                :|.|.....||   ||.....|               .|:.:.|:.....|.|.|:||:|.
  Rat   665 HHHEAPDSSHGKKTRESERNHRTTEAEPKTLEEPKHETKKLKTLSEYAQTLQLGWNGLLVLKNSC 729

  Fly   646 FPAKFHLTDGDTDIVESLMRDEEGKH---NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGL 705
            ||...|:.:||..::..|::|.....   .|:|.||||||.||||:|.:||  .|.:.:|:.:.:
  Rat   730 FPTSMHILEGDQGVISGLLKDHTSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLAI 794

  Fly   706 AGSTNDTNCD-----DASVQTRPLRNLVSYLKQKEAAGVISLL---NKETEATGVLYAFPPCDFS 762
            ..:.:....:     :..:|.|.|||||||||||:|||||||.   :|..::||:||||||||||
  Rat   795 QSTPSGPGAEGMPMVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDSTGMLYAFPPCDFS 859

  Fly   763 TELLKRTCHSLTEEGLKEDHLVIVVVR 789
            .:.|:....:|.:  |:|:|:|||:||
  Rat   860 QQYLQSALRTLGK--LEEEHMVIVIVR 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	59/177 (33%)
		RRM1_Spen	98..175	CDD:240754	36/79 (46%)
		RRM2_Spen	312..390	CDD:240755	42/77 (55%)
		RRM3_Spen	397..467	CDD:240756	43/69 (62%)
		SPOC	630..789	CDD:311609	71/171 (42%)
Rbm15b	XP_038938548.1	RRM1_RBM15B	134..215	CDD:409970	36/80 (45%)
		RRM2_RBM15B	325..409	CDD:409972	46/83 (55%)
		RRM3_RBM15B	412..487	CDD:409974	47/74 (64%)
		SF-CC1	568..>704	CDD:273721	24/137 (18%)
		SPOC	711..884	CDD:400205	72/174 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347813
Domainoid	1	1.000	136	1.000	Domainoid score	I4792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1952
OMA	1	1.010	-	-		QHG48807
OrthoDB	1	1.010	-	-		D215960at33208
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		otm45768
orthoMCL	1	0.900	-	-		OOG6_105436
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910