DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and RBM15B

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_037418.3	Gene:	RBM15B / 29890	HGNCID:	24303	Length:	890	Species:	Homo sapiens

Alignment Length:	907	Identity:	301/907 - (33%)
Similarity:	419/907 - (46%)	Gaps:	175/907 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSHRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERM 66
            ::|:...||               :.|.||......|.|.|.|.|:.:|.|. ||:..|.|..|.
Human    37 AAHKASGGA---------------KHPVPARARDKPRGSGSGGGGHRDGRGT-GDANHRASSGRS 85

  Fly    67 RRRLDRSPSRYGSPHREPYMRG------------PPPAERPA---------GYKVLCVSALPPKA 110
            .........|.|....:|...|            |||...||         .||.|.:|:|.|..
Human    86 SGSGAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYKTLLISSLSPAL 150

  Fly   111 PDDFIEETLYREYKKFGDFSVRLAHDLD-ERVAYVCFRTPEDAREAKHH--KPRLIIYDKMAIVE 172
            |.:.:|:.|:.::|:||:.|:||:|..: .|||||.||.|:|||||:.|  ..:|::||:...||
Human   151 PAEHLEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVE 215

  Fly   173 PVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPR 237
            |||       .|..|.|..       ..|.|......|     ||       ||    |....|.
Human   216 PVY-------LRGGGGSSR-------RSSSSSAAASTP-----PP-------GP----PAPADPL 250

  Fly   238 DYRPLHHDYPH------PPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHA----------- 285
            .|.|||..|.:      |...|||......|.....|.....|....|: |..|
Human   251 GYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLS-RERALDYYGLYDDRG 314

  Fly   286 -PYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPP 349
             ||..|...::       .:.||||..:||.||.|||:.::::.||||.|.|||:::::.||||.
Human   315 RPYGYPAVCEE-------DLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPA 372

  Fly   350 PGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLERE 414
            .|.|.|:||:::||||||||||:.:||:.||:...||||||..|.||:|:||||..||:..|.||
Human   373 RGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALARE 437

  Fly   415 FDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFK 479
            |||||:|:.|::.||:.:||||||:::||.||..:|||||||||:||||.|||:.........::
Human   438 FDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEETRYPQQYQ 502

  Fly   480 SSKPP---------------YDESALEYRRPEYDPYYEESAAY------APR---------GGYS 514
            .|..|               .|...:..|.|.:..|.:....:      :|.         .|||
Human   503 PSPLPVHYELLTDGYTRHRNLDADLVRDRTPPHLLYSDRDRTFLEGDWTSPSKSSDRRNSLEGYS 567

  Fly   515 -PYPPRGGYR-GRGGYRG-----------------RGRGMYHYHNDVHRPPHPGSLAGSSSSVPP 560
             ....|.|.| |..|.||                 |||..:..:.:..|....|..:...|...|
Human   568 RSVRSRSGERWGADGDRGLPKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGSGQQSERGSDRTP 632

  Fly   561 PGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVP 625
            ....::.......:.....:.|:||....||.......:.|.|........:.||.....|...|
Human   633 ERSRKENHSSEGTKESSSNSLSNSRHGAEERGHHHHHHEAADSSHGKKARDSERNHRTTEAEPKP 697

  Fly   626 ---------------DVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEGKH---N 672
                           :.|:.....|.|.|:||:|.||...|:.:||..::.||::|.....   .
Human   698 LEEPKHETKKLKNLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQ 762

  Fly   673 LRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAGSTNDTNCD-----DASVQTRPLRNLVSY 730
            |:|.||||||.||||:|.:||  .|.:.:|:.:....:.:....:     :..:|.|.|||||||
Human   763 LKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLATQATPSGLGTEGMPTVEPGLQRRLLRNLVSY 827

  Fly   731 LKQKEAAGVISLL---NKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVR 789
            ||||:|||||||.   :|..:.||:||||||||||.:.|:....:|.:  |:|:|:|||:||
Human   828 LKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTLGK--LEEEHMVIVIVR 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	59/190 (31%)
		RRM1_Spen	98..175	CDD:240754	36/79 (46%)
		RRM2_Spen	312..390	CDD:240755	42/77 (55%)
		RRM3_Spen	397..467	CDD:240756	43/69 (62%)
		SPOC	630..789	CDD:311609	72/171 (42%)
RBM15B	NP_037418.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133		27/111 (24%)
		RRM1_RBM15B	137..218	CDD:240998	36/80 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..253		12/56 (21%)
		RRM2_RBM15B	329..413	CDD:241000	46/83 (55%)
		RRM3_RBM15B	416..491	CDD:241002	47/74 (64%)
		RRM	529..>639	CDD:330708	21/109 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..705		29/157 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	593..597		0/3 (0%)
		SPOC	712..887	CDD:311609	73/176 (41%)
		Interaction with Epstein-Barr virus BMLF1	722..890		74/168 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154196
Domainoid	1	1.000	138	1.000	Domainoid score	I4848
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1972
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48807
OrthoDB	1	1.010	-	-		D215960at33208
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		otm41646
orthoMCL	1	0.900	-	-		OOG6_105436
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5131
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840