DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nito and Raver2

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_898845.1	Gene:	Raver2 / 242570	MGIID:	2443623	Length:	673	Species:	Mus musculus

Alignment Length:	609	Identity:	114/609 - (18%)
Similarity:	177/609 - (29%)	Gaps:	230/609 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 VQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKR------PPPGTGNAFAFVRYQ 362
            :||.|     ..|...||.::...:|...:...||     :|:|      ...|....:.||.|.
Mouse   126 LQPTD-----ALLCITNLPISFTLEEFEELVRAYG-----NIERCFLVYSEVTGHSKGYGFVEYM 180

  Fly   363 NLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLERE--------FDR-- 417
            ..|.|.:|::||.|:.:|             |:.::    ..|..|..|..|        .|:
Mouse   181 KKDFAAKARLELLGRQMG-------------ASALF----AQWMDVNLLASELIHSKCLCIDKLP 228

  Fly   418 ------------FGAIKK--------IEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRL 462
                        |..|.|        .|...|..:|.::|.|.|.|....:...|..:.|.:.:|
Mouse   229 SDYSDSEELLQLFSGIHKPVFCQLAQDEGSHGGGFAVVEYSTAEHAEEVQQVADGITIKGSQVQL 293

  Fly   463 ---------RTDFAE---------------LPGATPAAPFKS-------------------SKP- 483
                     |:..|.               ||...|....||                   .||
Mouse   294 SFCAPGAPGRSTLAVLIAAQRAMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQLCGRAMKPV 358

  Fly   484 ----PYDESALEYRRPEYDPYYEESAAYAPRG--------GYSPYP---------PRGGYRGRGG 527
                |.....|....|....::.::...:..|        ..||.|         .......:.|
Mouse   359 LGVAPSLSHLLSPSLPSAILHFSKAQQSSAVGNTSSLILQNLSPLPLIQQQLMKFDNAHTNNKPG 423

  Fly   528 YRGRGRGM-----------------YHYHNDVHR-----PPHP------GSLAGSSSSVPP---- 560
            ..|....|                 ..:|.:.|:     ||..      |.|...|:.:|.
Mouse   424 LLGEPPAMVLQPALAIGPPLPLKTDLGHHGEAHKTSNLIPPQTTLAAGLGMLPFFSNQLPAGQAG 488

  Fly   561 PGGVEDEWRRPPGESYDRGARSSSRE-----PGVE-----RSRSRSPLKRARSP--GSDSDTS-- 611
            ||....:.::....|....:.|.|:.     ||:.     ....::|..:.:..  .|.:.||
Mouse   489 PGRGTTQEKQSASVSISEASFSGSQHYLQTFPGLPAGGPLTGNQKTPQSQPKGTEVASKNQTSLL 553

  Fly   612 --------TRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEE 668
                    ..:|..|..||.:|.|.  .||...|        .|.|   |...::|::::.:..|
Mouse   554 GEPPKEIRLSKNPYLNLASVLPSVC--LSTAGKG--------MPPK---TGIASNILDAISQGSE 605

  Fly   669 GKHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCDDASVQTRPLRNL---VSY 730
            .:|.|                :|.||.|.|               .:|.: |...|||.   .||
Mouse   606 SQHAL----------------EKCIAYSPS---------------IEDYA-QASSLRNEKRGSSY 638

  Fly   731 LKQKEAAGVISLLNKETEATGVLY 754
            |......|.:.|..:..:.|||.|
Mouse   639 LISAPEGGPVELAGQHPQDTGVSY 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	19/83 (23%)
		RRM3_Spen	397..467	CDD:240756	19/108 (18%)
		SPOC	630..789	CDD:311609	29/128 (23%)
Raver2	NP_898845.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		RRM_SF	59..128	CDD:302621	0/1 (0%)
		RRM2_RAVER2	132..208	CDD:241110	21/97 (22%)
		RRM_SF	218..314	CDD:302621	16/95 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..549		10/67 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930