Protein Alignment nito and Rbm15

DIOPT Version :10

• Sequence 1: NP_610339.1
• Gene: nito / 35756
• FlyBaseID: FBgn0027548
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_001039272.1
• Gene: Rbm15 / 229700
• MGIID: 2443205
• Length: 962
• Species: Mus musculus
• Alignment Length: 974
• Identity: 338/974 - (34%)
• Similarity: 444/974 - (45%)
• Gaps: 270/974 - (27%)

  Fly    22 RSASRSPGPASRS-----SLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRR--RLDRSPSRYGS 79
            :...|||....||     |.||..||...|...||.  |.|..:......||  .||:|.||.||
Mouse    46 KGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSN--GSSSGKTDSGGSRRSLHLDKSSSRGGS 108

  Fly    80 PHRE----------------------------PYMRGPPPAERPAG-------------YKVLCV 103
            ...|                            ...||.....|.:|             ||.|.:
Mouse   109 REYETGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGVEYKTLKI 173

  Fly   104 SALPPKAPDDFIEETLYREYKKFGDFSVRLAH-----DLDERVAYVCFRTPEDAREAKHHKPRLI 163
            |.|..:..|:.:|:.|:.|:|:|||.||:::|     ..|||||:|.||.|||||.|||.:.||:
Mouse   174 SELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLV 238

  Fly   164 IYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPH 228
            :||:...:|.||.|        |..|.||.|.:.|..|.|.:|..|. .||..   |....|...
Mouse   239 LYDRPLKIEAVYVS--------RRRSRSPLDKDAYAPSSSVVGTSVG-SHRHA---PGGGGGQRS 291

  Fly   229 MHP--HAVHPRDYR----PLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRP---LAPR-- 282
            :.|  .|:..||||    .|....|.||  |||     |..|........|..:||   |.||
Mouse   292 LSPGGAALGYRDYRLQQLALGRLPPPPP--PPL-----PRELERERDYPFYDRVRPAYSLEPRVG 349

  Fly   283 ---PHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDID 344
               ..||:.:           :..:.||||..:.||||.|||::|:.:::|||.|.::||:.::|
Mouse   350 AGAGAAPFRE-----------VDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVD 403

  Fly   345 IKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVT 409
            ||||..|..:.:.|::::||||:||||:.:||:.|.:...||||||.||.||:|:||||.|..:.
Mouse   404 IKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLA 468

  Fly   410 QLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAE------ 468
            .|.|||||||.|:.|:|:||:.:||||||:::||.||...|||||||||:||||.|||:
Mouse   469 ALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQ 533

  Fly   469 ------LP-----------GATPAAPFKSSK---PPYDESALEYRRPEYDPYYE----------- 502
                  ||           |.....|.:|::   ||     |.||..:.|.|.:
Mouse   534 QQYLQPLPLTHYELVTDTFGHRAPDPLRSARDRTPP-----LLYRDRDRDLYTDSDWVPPPPPVR 593

  Fly   503 ESAAYAPRGGYSPYPPRGGY-RGRGGYR-GRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVE 565
            |.:|.|.....:.|.|.... |.|.|:. .|.||      |...|        ||...|
Mouse   594 ERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRG------DRDLP--------SSRDQP------ 638

  Fly   566 DEWRRPPGESYDRGARSSSREPGVERSR---------SRSP---------------------LKR 600
             ..||.|.||   |.|...|.|..||.|         .|||                     |:|
Mouse   639 -RKRRLPEES---GGRHLDRSPESERPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLER 699

  Fly   601 ARSP---------GSDSDTSTRRNDALA-----------------------------SAST---- 623
            : ||         .|.||...|:|.|.|                             ||||
Mouse   700 S-SPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEGKNPLKKEDRSDGNAPSASTSSSK 763

  Fly   624 --------------VPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEE--GK-H 671
                          |...:.|....|.|.|:||:|.||:..||..||..:..||:.:..  || .
Mouse   764 QKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVA 828

  Fly   672 NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAG------STNDTNCDDASVQTRPLRNLV 728
            .|:||||||||.||||:|.:||  |..:.:||.:.:.|      |::....|.|:...|||||||
Mouse   829 QLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLV 893

  Fly   729 SYLKQKEAAGVISLL---NKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVR 789
            ||||||:|||||||.   ||:.|.||||:|||||:||.:.|.....:|.:.  :||:||:::||
Mouse   894 SYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKS--EEDYLVMIIVR 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_610339.1	RRM1_Spen	98..175	CDD:409749	37/81 (46%)
		RRM2_Spen	312..390	CDD:240755	36/77 (47%)
		RRM3_Spen	397..468	CDD:409750	44/70 (63%)
		SPOC_RBM15-like	634..790	CDD:439207	81/170 (48%)
Rbm15	NP_001039272.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..167		29/122 (24%)
		RRM1_RBM15	168..250	CDD:409969	37/81 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..297		13/43 (30%)
		RRM2_RBM15	366..452	CDD:409971	41/85 (48%)
		RRM3_RBM15	455..527	CDD:409973	45/71 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..779		56/255 (22%)
		Metaviral_G	<653..782	CDD:462833	24/129 (19%)
		SPOC_SF	788..955	CDD:459247	79/168 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	866..885		4/18 (22%)