DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and Rbm15

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001039272.1	Gene:	Rbm15 / 229700	MGIID:	2443205	Length:	962	Species:	Mus musculus

Alignment Length:	974	Identity:	338/974 - (34%)
Similarity:	444/974 - (45%)	Gaps:	270/974 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RSASRSPGPASRS-----SLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRR--RLDRSPSRYGS 79
            :...|||....||     |.||..||...|...||.  |.|..:......||  .||:|.||.||
Mouse    46 KGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSN--GSSSGKTDSGGSRRSLHLDKSSSRGGS 108

  Fly    80 PHRE----------------------------PYMRGPPPAERPAG-------------YKVLCV 103
            ...|                            ...||.....|.:|             ||.|.:
Mouse   109 REYETGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDGVEYKTLKI 173

  Fly   104 SALPPKAPDDFIEETLYREYKKFGDFSVRLAH-----DLDERVAYVCFRTPEDAREAKHHKPRLI 163
            |.|..:..|:.:|:.|:.|:|:|||.||:::|     ..|||||:|.||.|||||.|||.:.||:
Mouse   174 SELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAFVNFRRPEDARAAKHARGRLV 238

  Fly   164 IYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPH 228
            :||:...:|.||.|        |..|.||.|.:.|..|.|.:|..|. .||..   |....|...
Mouse   239 LYDRPLKIEAVYVS--------RRRSRSPLDKDAYAPSSSVVGTSVG-SHRHA---PGGGGGQRS 291

  Fly   229 MHP--HAVHPRDYR----PLHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRP---LAPR-- 282
            :.|  .|:..||||    .|....|.||  |||     |..|........|..:||   |.||
Mouse   292 LSPGGAALGYRDYRLQQLALGRLPPPPP--PPL-----PRELERERDYPFYDRVRPAYSLEPRVG 349

  Fly   283 ---PHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDID 344
               ..||:.:           :..:.||||..:.||||.|||::|:.:::|||.|.::||:.::|
Mouse   350 AGAGAAPFRE-----------VDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVD 403

  Fly   345 IKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVT 409
            ||||..|..:.:.|::::||||:||||:.:||:.|.:...||||||.||.||:|:||||.|..:.
Mouse   404 IKRPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLA 468

  Fly   410 QLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAE------ 468
            .|.|||||||.|:.|:|:||:.:||||||:::||.||...|||||||||:||||.|||:
Mouse   469 ALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQ 533

  Fly   469 ------LP-----------GATPAAPFKSSK---PPYDESALEYRRPEYDPYYE----------- 502
                  ||           |.....|.:|::   ||     |.||..:.|.|.:
Mouse   534 QQYLQPLPLTHYELVTDTFGHRAPDPLRSARDRTPP-----LLYRDRDRDLYTDSDWVPPPPPVR 593

  Fly   503 ESAAYAPRGGYSPYPPRGGY-RGRGGYR-GRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVE 565
            |.:|.|.....:.|.|.... |.|.|:. .|.||      |...|        ||...|
Mouse   594 ERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRG------DRDLP--------SSRDQP------ 638

  Fly   566 DEWRRPPGESYDRGARSSSREPGVERSR---------SRSP---------------------LKR 600
             ..||.|.||   |.|...|.|..||.|         .|||                     |:|
Mouse   639 -RKRRLPEES---GGRHLDRSPESERPRKQRHCTPSPDRSPELSSNRDRYNSDNDRSSRLLLLER 699

  Fly   601 ARSP---------GSDSDTSTRRNDALA-----------------------------SAST---- 623
            : ||         .|.||...|:|.|.|                             ||||
Mouse   700 S-SPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEGKNPLKKEDRSDGNAPSASTSSSK 763

  Fly   624 --------------VPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEE--GK-H 671
                          |...:.|....|.|.|:||:|.||:..||..||..:..||:.:..  || .
Mouse   764 QKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTGGKVA 828

  Fly   672 NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAG------STNDTNCDDASVQTRPLRNLV 728
            .|:||||||||.||||:|.:||  |..:.:||.:.:.|      |::....|.|:...|||||||
Mouse   829 QLKITQRLRLDQPKLDEVTRRIKVAGPNGYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLV 893

  Fly   729 SYLKQKEAAGVISLL---NKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVR 789
            ||||||:|||||||.   ||:.|.||||:|||||:||.:.|.....:|.:.  :||:||:::||
Mouse   894 SYLKQKQAAGVISLPVGGNKDKENTGVLHAFPPCEFSQQFLDSPAKALAKS--EEDYLVMIIVR 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	68/214 (32%)
		RRM1_Spen	98..175	CDD:240754	37/81 (46%)
		RRM2_Spen	312..390	CDD:240755	36/77 (47%)
		RRM3_Spen	397..467	CDD:240756	43/69 (62%)
		SPOC	630..789	CDD:311609	80/172 (47%)
Rbm15	NP_001039272.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..167		29/122 (24%)
		RRM1_RBM15	168..250	CDD:240997	37/81 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..297		13/43 (30%)
		RRM2_RBM15	366..452	CDD:240999	41/85 (48%)
		RRM3_RBM15	455..527	CDD:241001	45/71 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..779		56/255 (22%)
		RRM	623..>751	CDD:330708	34/152 (22%)
		SPOC	781..955	CDD:311609	80/175 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..885		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844448
Domainoid	1	1.000	136	1.000	Domainoid score	I4909
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2027
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48807
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		otm43690
orthoMCL	1	0.900	-	-		OOG6_105436
Panther	1	1.100	-	-	LDO	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5131
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.830