DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and grld-1

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_741283.1	Gene:	grld-1 / 176827	WormBaseID:	WBGene00017929	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	701	Identity:	169/701 - (24%)
Similarity:	264/701 - (37%)	Gaps:	227/701 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GSPHREP-------YMRGPPPAERPAGYKVLCVSALPPKAPDDFIEETLYREYKKFGDFSVRLAH 135
            |.|...|       |.|....:..|..|..|.:|....:...:.|::.|.:|.||:..|.:::..
Worm     6 GRPQYRPNCNGLSSYYRERFGSHSPEVYLNLRISGFDDRLEREQIKQYLTQELKKYAPFEIKVVK 70

  Fly   136 --DLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGHSMSPPDYERY 198
              :.|||:|||.|...:.||     |.|..:.|::
Worm    71 NPEEDERLAYVNFERNDCAR-----KVRYTLMDRL------------------------------ 100

  Fly   199 HYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGPPLHRGGHPHH 263
               :|.:|:.|..|......|...:|.|...: .|.|..|.:               ..||....
Worm   101 ---KSVLGKRVQCDPAGILRDQEGKYIPDRFN-RAQHGADSK---------------REGGSGSG 146

  Fly   264 LHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADD 328
            ..|.                  |.::|.:.:.|          :||..:|||||.||:...:.:.
Worm   147 NRGR------------------PTKEPSTWRLK----------QDDDEATRTLFVGNMPSDVKER 183

  Fly   329 ELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYI--GKFQCKIGYGKV 391
            |:|.:|.::|.|:::||| .|..|..|:|||.:|.:|.|.:||.|...:.|  |..:.||||||.
Worm   184 EIRHVFEEHGKVEEVDIK-TPINTDAAYAFVMFQTVDQAIQAKAEEQDRPIRAGGSRMKIGYGKS 247

  Fly   392 TPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAAVKEMRGFPLG 456
            ..:.|:::||||:|.....|::.|..||.::.|:|..|:||||:.||....:..|.:.:||..:.
Worm   248 QVSRRLFVGGLGSWCDKEILQKAFGEFGFVENIDYDHGQPYAYVVYENTHTSQEACRSLRGACIS 312

  Fly   457 GPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGG 521
            .....:..|:|:                 |.:|    :||...:..:
Worm   313 KGNHPIMVDYAK-----------------DLTA----QPEKQQFMRK------------------ 338

  Fly   522 YRGRGGYRGRGRGMYHYHNDVHRPPHPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSRE 586
                                                                       |.:|:.
Worm   339 -----------------------------------------------------------RRASKS 344

  Fly   587 PGVERSRSRSPLKRARSPGSDSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFH 651
            | |..|..|:|      |||..|..  ||.|        ::....:..|:|.:.||.:.:|.||:
Worm   345 P-VGASAVRTP------PGSPKDVV--RNFA--------ELEEAYAATWSGKMALKKTDYPVKFY 392

  Fly   652 LTDGDTDIVESLMRDEEG-KHNLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTNDTNCD 715
            ...|...:...|:|||:. ...|.|||||.|....|  :..::||.||..:.:|:.  |......
Worm   393 RVYGAERLPVKLLRDEDDVPLRLLITQRLSLSSQNL--LFDKLASCSSKELSLGVI--TGKKELS 453

  Fly   716 DASVQTRPLRNLVSYLKQKEAAGVISLLNKETEATGVLYAFPPCDFSTELL 766
            |       |:.||:|...||||||:      |...|:||.||.|:|:.:||
Worm   454 D-------LQPLVNYFTNKEAAGVV------TVPGGILYIFPFCEFALKLL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	32/153 (21%)
		RRM1_Spen	98..175	CDD:240754	21/78 (27%)
		RRM2_Spen	312..390	CDD:240755	33/79 (42%)
		RRM3_Spen	397..467	CDD:240756	22/69 (32%)
		SPOC	630..789	CDD:311609	47/138 (34%)
grld-1	NP_741283.1	RRM_SF	33..>93	CDD:302621	19/64 (30%)
		RRM_SF	167..246	CDD:302621	33/79 (42%)
		RRM3_Spen	253..324	CDD:240756	22/70 (31%)
		SPOC	376..482	CDD:285043	41/122 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I6812
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I2916
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48807
OrthoDB	1	1.010	-	-		D215960at33208
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		oto18196
orthoMCL	1	0.900	-	-		OOG6_105436
Panther	1	1.100	-	-	LDO	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5131
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010