Protein Alignment nito and nito

DIOPT Version :10

• Sequence 1: NP_610339.1
• Gene: nito / 35756
• FlyBaseID: FBgn0027548
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_314009.5
• Gene: nito / 1274805
• VectorBaseID: AGAMI1_009835
• Length: 790
• Species: Anopheles gambiae
• Alignment Length: 838
• Identity: 547/838 - (65%)
• Similarity: 630/838 - (75%)
• Gaps: 93/838 - (11%)

  Fly     1 MSSHRDGAGADRITIKIHNMKRSASRSPGPAS--RSSLSRNSRSMGRGYDNGSGVPGDSPERLSP 63
            |||.| .:..||||:|||||||||||...|.|  |||:.|        ||:      .|.||::|
Mosquito     1 MSSIR-SSERDRITVKIHNMKRSASRESPPRSKRRSSIGR--------YDD------SSDERVTP 50

  Fly    64 ERMRRRLDRSPS---RYGSPHREPYMRGPPPAE--------RPAGYKVLCVSALPPKAPDDFIEE 117
            :|||||:.||||   ||.||||:.|......|:        ....|||||||||.|||.::||:|
Mosquito    51 DRMRRRVARSPSPRARYASPHRDEYSSSRSRADIGSSGGGSERYSYKVLCVSALHPKASEEFIKE 115

  Fly   118 TLYREYKKFGDFSVRLAHDLDERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPE 182
            |||||||||||||:|::||||||:||||||||||||||||.|.|:|::||:|:|||||:|:....
Mosquito   116 TLYREYKKFGDFSIRISHDLDERLAYVCFRTPEDAREAKHAKSRIILHDKVALVEPVYESSKSES 180

  Fly   183 YRPRGHSMSPPDYERYHYSRSPMGQGV-PLDHRRPP-IDPYDRYGPP---HMHPHAVHPRDYR-P 241
            || |..|.|||:|:|::|:|||   || |.|.|||| ..|||.||||   .||    || |:| |
Mosquito   181 YR-RPRSASPPEYDRHYYARSP---GVPPPDRRRPPEHHPYDGYGPPPGGRMH----HP-DFRPP 236

  Fly   242 LHHDYPHPPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQP 306
            :||||  .|||||:|..| |.|:|...|.|.|.| ||..|||.||:||.|:|||||||||||:||
Mosquito   237 MHHDY--LPRGPPMHHHG-PPHMHPGPPHHHYMP-RPYMPRPRAPFEKQENKKDKFPNYLHHIQP 297

  Fly   307 EDDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAK 371
            |||||:||||||||||:.|:||||||||||||:|:|||||||.|||||||||||||.||||||||
Mosquito   298 EDDPLATRTLFAGNLEINISDDELRRIFGKYGLVEDIDIKRPAPGTGNAFAFVRYQTLDMAHRAK 362

  Fly   372 IELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQ 436
            :||||||||||||||||||.||.||:|:|||||||||||||||||||||||||||.||:..|:|.
Mosquito   363 VELSGQYIGKFQCKIGYGKATPTTRIWVGGLGAWTSVTQLEREFDRFGAIKKIEYAKGDTQAFIL 427

  Fly   437 YETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRR-PEYD-- 498
            |::::||||||||||||.||||:||:|.|||: .|..|  ||  :|.|::|...|||| |||:
Mosquito   428 YDSIDAATAAVKEMRGFALGGPDRRIRIDFAD-NGTVP--PF--AKRPFEEGGGEYRRVPEYEYP 487

  Fly   499 ---PYYEESAAYAPRGGYSPYPPRGGYRGRG------GYRGRGRGMYH--YHNDVHRPPHPGSLA 552
               |.|::.|.....|||.    ...:||||      ||||||.|.:.  :|:|.|||...|.
Mosquito   488 DGAPPYDDGAPGYGGGGYG----ARSFRGRGSGGSGSGYRGRGGGSFRGGFHHDGHRPAGAGG-- 546

  Fly   553 GSSSSVPP---PGGVEDEWRRPPG------ESYDRGARSSSREP-GVERSRSRSPLKRARSPG-S 606
                  ||   ||| |:|||||||      ..||:..||.|||| |::|||||||  |.|||. |
Mosquito   547 ------PPHHGPGG-EEEWRRPPGGGGGEPGEYDQRRRSGSREPGGIDRSRSRSP--RRRSPADS 602

  Fly   607 DSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAKFHLTDGDTDIVESLMRDEEGKH 671
            |||:|||||..|.||.|:.:||||.||||.||||||||||||||||||||.|||:.||:||:|||
Mosquito   603 DSDSSTRRNGVLTSARTLSEVARKSSTVWQGALILKSSLFPAKFHLTDGDADIVDELMKDEDGKH 667

  Fly   672 NLRITQRLRLDPPKLDDVQKRIASSSSHAIFMGLAGSTND-TNCDDASVQTRPLRNLVSYLKQKE 735
            :||||||||||.|||:||||||::|||||||:||.||... ::.||||||||||||||:||||||
Mosquito   668 HLRITQRLRLDQPKLEDVQKRISTSSSHAIFLGLPGSNPAVSSSDDASVQTRPLRNLVTYLKQKE 732

  Fly   736 AAGVISLLNKETEATGVLYAFPPCDFSTELLKRTCHSLTEEGLKEDHLVIVVVRGGTA 793
            |||||||||||||||||||.||||:|||||||||||:|||||||||||||||||||||
Mosquito   733 AAGVISLLNKETEATGVLYTFPPCEFSTELLKRTCHTLTEEGLKEDHLVIVVVRGGTA 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_610339.1	RRM1_Spen	98..175	CDD:409749	60/76 (79%)
		RRM2_Spen	312..390	CDD:240755	68/77 (88%)
		RRM3_Spen	397..468	CDD:409750	54/70 (77%)
		SPOC_RBM15-like	634..790	CDD:439207	132/156 (85%)
nito	XP_314009.5	None