DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and Rbm15b

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_780611.3	Gene:	Rbm15b / 109095	MGIID:	1923598	Length:	887	Species:	Mus musculus

Alignment Length:	931	Identity:	314/931 - (33%)
Similarity:	418/931 - (44%)	Gaps:	257/931 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRR 68
            ||||..|...     |.:.|..||.|.....  .|..::.|   |.|:|  |.|| |.||
Mouse    66 HRDGRAAGDA-----NHRASGGRSSGAPGGG--GRTGKASG---DPGAG--GASP-RASP----- 112

  Fly    69 RLDRSPSRYGSPHREPYMRGPPPAERPAG--------YKVLCVSALPPKAPDDFIEETLYREYKK 125
             |...|              |||...|||        ||.|.:|:|.|..|.:.:|:.|:.::|:
Mouse   113 -LPPPP--------------PPPGAEPAGPGSTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKR 162

  Fly   126 FGDFSVRLAHDLD-ERVAYVCFRTPEDAREAKHH--KPRLIIYDKMAIVEPVYKSTTRPEYRPRG 187
            ||:.|:||:|..: .|||||.||.|:|||||:.|  ..:|::||:...|||||.         ||
Mouse   163 FGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYL---------RG 218

  Fly   188 HSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPH---- 248
            ...|      ...|.|......|     ||       ||    |....|..|.|||..|.:
Mouse   219 GGSS------RRSSSSSAAASTP-----PP-------GP----PAPADPLGYLPLHGGYQYKQRS 261

  Fly   249 --PPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYL----HHVQPE 307
              |...|||......|.....|.....|....|:......|......:.:...|.    ..:.||
Mouse   262 LSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYQAVCEEDLMPE 326

  Fly   308 DDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKI 372
            ||..:||.||.|||:.::::.||||.|.|||:::::.||||..|.|.|:||:::||||||||||:
Mouse   327 DDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKV 391

  Fly   373 ELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQY 437
            .:||:.||:...||||||..|.||:|:||||..||:..|.|||||||:|:.|::.||:.:|||||
Mouse   392 AMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQY 456

  Fly   438 ETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRP-EYDPYY 501
            |:::||.||..:|||||||||:||||.|||:                    |.|.|.| :|.|
Mouse   457 ESLDAAQAACAKMRGFPLGGPDRRLRVDFAK--------------------AEETRYPQQYQP-- 499

  Fly   502 EESAAYAPRGGYSPYPPR-----GGY-RGR---GGYRGRGRGMYHYHNDVHRPPH---------- 547
                        ||.|..     .|| |.|   ...|.|.|          .|||
Mouse   500 ------------SPLPVHYELLTDGYTRHRNLDADLRVRDR----------TPPHLLYSDRDRTF 542

  Fly   548 --------------PGSLAGSSSSVPPPGGVE-------------DEWRRPPGESYDRG------ 579
                          ..||.|.|.||....|..             :|.|:....|.|||
Mouse   543 LEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGGDGDRSIAKPWEERRKRRSLSSDRGRTTHSP 607

  Fly   580 --------------ARSSSREPGVERSRSR------------SPLKRAR--------------SP 604
                          .|.|.|.|  ||||..            :.|..:|              :|
Mouse   608 YEERSRTKGGGQQSERGSDRTP--ERSRKENHSSEGTKESGSNSLSNSRHGAEERSHHHHHHEAP 670

  Fly   605 GSDSDTSTR---RNDALASA---------------STVPDVARKCSTVWTGALILKSSLFPAKFH 651
            .|.....||   ||.....|               .|:.:.|:.....|.|.|:||:|.||...|
Mouse   671 DSSHGKKTRESERNHRTTEAEPKTLEEPKHETKKLKTLSEYAQTLQLGWNGLLVLKNSCFPTSMH 735

  Fly   652 LTDGDTDIVESLMRDEEGKH---NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAGSTND 711
            :.:||..::..|::|.....   .|:|.||||||.||||:|.:||  .|.:.:|:.:.:..:.:.
Mouse   736 ILEGDQGVISGLLKDHPSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLAIQSTPSG 800

  Fly   712 TNCD-----DASVQTRPLRNLVSYLKQKEAAGVISLL---NKETEATGVLYAFPPCDFSTELLKR 768
            ...:     :..:|.|.|||||||||||:|||||||.   :|..:.||:||||||||||.:.|:.
Mouse   801 PGAEGMPVVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDNTGMLYAFPPCDFSQQYLQS 865

  Fly   769 TCHSLTEEGLKEDHLVIVVVR 789
            ...:|.:  |:|:|:|||:||
Mouse   866 ALRTLGK--LEEEHMVIVIVR 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	59/177 (33%)
		RRM1_Spen	98..175	CDD:240754	36/79 (46%)
		RRM2_Spen	312..390	CDD:240755	42/77 (55%)
		RRM3_Spen	397..467	CDD:240756	43/69 (62%)
		SPOC	630..789	CDD:311609	71/171 (42%)
Rbm15b	NP_780611.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132		29/98 (30%)
		RRM1_RBM15B	134..215	CDD:240998	36/80 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..249		13/64 (20%)
		RRM2_RBM15B	325..409	CDD:241000	46/83 (55%)
		RRM3_RBM15B	412..487	CDD:241002	47/74 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..703		30/155 (19%)
		SR-25	568..>712	CDD:287471	25/145 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	590..594		1/3 (33%)
		Interaction with Epstein-Barr virus BMLF1. /evidence=ECO:0000250	719..887		73/168 (43%)
		SPOC	719..854	CDD:285043	56/134 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844438
Domainoid	1	1.000	136	1.000	Domainoid score	I4909
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2027
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48807
OrthoDB	1	1.010	-	-		D215960at33208
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		otm43690
orthoMCL	1	0.900	-	-		OOG6_105436
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5131
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800