Protein Alignment nito and Rbm15b

DIOPT Version :10

• Sequence 1: NP_610339.1
• Gene: nito / 35756
• FlyBaseID: FBgn0027548
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_780611.3
• Gene: Rbm15b / 109095
• MGIID: 1923598
• Length: 887
• Species: Mus musculus
• Alignment Length: 931
• Identity: 314/931 - (33%)
• Similarity: 418/931 - (44%)
• Gaps: 257/931 - (27%)

  Fly     4 HRDGAGADRITIKIHNMKRSASRSPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRR 68
            ||||..|...     |.:.|..||.|.....  .|..::.|   |.|:|  |.|| |.||
Mouse    66 HRDGRAAGDA-----NHRASGGRSSGAPGGG--GRTGKASG---DPGAG--GASP-RASP----- 112

  Fly    69 RLDRSPSRYGSPHREPYMRGPPPAERPAG--------YKVLCVSALPPKAPDDFIEETLYREYKK 125
             |...|              |||...|||        ||.|.:|:|.|..|.:.:|:.|:.::|:
Mouse   113 -LPPPP--------------PPPGAEPAGPGSTAAPEYKTLLISSLSPALPAEHLEDRLFHQFKR 162

  Fly   126 FGDFSVRLAHDLD-ERVAYVCFRTPEDAREAKHH--KPRLIIYDKMAIVEPVYKSTTRPEYRPRG 187
            ||:.|:||:|..: .|||||.||.|:|||||:.|  ..:|::||:...|||||.         ||
Mouse   163 FGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYL---------RG 218

  Fly   188 HSMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPH---- 248
            ...|      ...|.|......|     ||       ||    |....|..|.|||..|.:
Mouse   219 GGSS------RRSSSSSAAASTP-----PP-------GP----PAPADPLGYLPLHGGYQYKQRS 261

  Fly   249 --PPRGPPLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYL----HHVQPE 307
              |...|||......|.....|.....|....|:......|......:.:...|.    ..:.||
Mouse   262 LSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYQAVCEEDLMPE 326

  Fly   308 DDPLSTRTLFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKI 372
            ||..:||.||.|||:.::::.||||.|.|||:::::.||||..|.|.|:||:::||||||||||:
Mouse   327 DDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKV 391

  Fly   373 ELSGQYIGKFQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQY 437
            .:||:.||:...||||||..|.||:|:||||..||:..|.|||||||:|:.|::.||:.:|||||
Mouse   392 AMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQY 456

  Fly   438 ETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSSKPPYDESALEYRRP-EYDPYY 501
            |:::||.||..:|||||||||:||||.|||:                    |.|.|.| :|.|
Mouse   457 ESLDAAQAACAKMRGFPLGGPDRRLRVDFAK--------------------AEETRYPQQYQP-- 499

  Fly   502 EESAAYAPRGGYSPYPPR-----GGY-RGR---GGYRGRGRGMYHYHNDVHRPPH---------- 547
                        ||.|..     .|| |.|   ...|.|.|          .|||
Mouse   500 ------------SPLPVHYELLTDGYTRHRNLDADLRVRDR----------TPPHLLYSDRDRTF 542

  Fly   548 --------------PGSLAGSSSSVPPPGGVE-------------DEWRRPPGESYDRG------ 579
                          ..||.|.|.||....|..             :|.|:....|.|||
Mouse   543 LEGDWTSLSKSSDRRNSLEGYSRSVRSRSGERWGGDGDRSIAKPWEERRKRRSLSSDRGRTTHSP 607

  Fly   580 --------------ARSSSREPGVERSRSR------------SPLKRAR--------------SP 604
                          .|.|.|.|  ||||..            :.|..:|              :|
Mouse   608 YEERSRTKGGGQQSERGSDRTP--ERSRKENHSSEGTKESGSNSLSNSRHGAEERSHHHHHHEAP 670

  Fly   605 GSDSDTSTR---RNDALASA---------------STVPDVARKCSTVWTGALILKSSLFPAKFH 651
            .|.....||   ||.....|               .|:.:.|:.....|.|.|:||:|.||...|
Mouse   671 DSSHGKKTRESERNHRTTEAEPKTLEEPKHETKKLKTLSEYAQTLQLGWNGLLVLKNSCFPTSMH 735

  Fly   652 LTDGDTDIVESLMRDEEGKH---NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAGSTND 711
            :.:||..::..|::|.....   .|:|.||||||.||||:|.:||  .|.:.:|:.:.:..:.:.
Mouse   736 ILEGDQGVISGLLKDHPSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLAIQSTPSG 800

  Fly   712 TNCD-----DASVQTRPLRNLVSYLKQKEAAGVISLL---NKETEATGVLYAFPPCDFSTELLKR 768
            ...:     :..:|.|.|||||||||||:|||||||.   :|..:.||:||||||||||.:.|:.
Mouse   801 PGAEGMPVVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDNTGMLYAFPPCDFSQQYLQS 865

  Fly   769 TCHSLTEEGLKEDHLVIVVVR 789
            ...:|.:  |:|:|:|||:||
Mouse   866 ALRTLGK--LEEEHMVIVIVR 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_610339.1	RRM1_Spen	98..175	CDD:409749	36/79 (46%)
		RRM2_Spen	312..390	CDD:240755	42/77 (55%)
		RRM3_Spen	397..468	CDD:409750	44/70 (63%)
		SPOC_RBM15-like	634..790	CDD:439207	73/169 (43%)
Rbm15b	NP_780611.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..132		29/98 (30%)
		RRM1_RBM15B	134..215	CDD:409970	36/80 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	215..249		13/64 (20%)
		RRM2_RBM15B	325..409	CDD:409972	46/83 (55%)
		RRM3_RBM15B	412..487	CDD:409974	47/74 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..703		30/155 (19%)
		SF-CC1	568..>704	CDD:273721	24/137 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	590..594		1/3 (33%)
		SPOC_RBM15B	718..885	CDD:439213	73/169 (43%)
		Interaction with Epstein-Barr virus BMLF1. /evidence=ECO:0000250	719..887		73/168 (43%)