DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nito and RBM14-RBM4

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001185774.1	Gene:	RBM14-RBM4 / 100526737	HGNCID:	38840	Length:	339	Species:	Homo sapiens

Alignment Length:	418	Identity:	76/418 - (18%)
Similarity:	117/418 - (27%)	Gaps:	200/418 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LHGHAPPHQYAPMRPLAPRPHAPYEKPESKKDKFPNYLHHVQPEDDPLSTRTLFAGNLEVTIADD 328
            |||    |:..|.|.|......|                      .||:|..:|.||:.......
Human    55 LHG----HELRPGRALVVEMSRP----------------------RPLNTWKIFVGNVSAACTSQ 93

  Fly   329 ELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELS----------GQYIGKFQ 383
            |||.:|.:.|.|.:.|:.:                   ..|..::||          |...|.::
Human    94 ELRSLFERRGRVIECDVVK-------------------GKRMHVQLSTSRLRTAPGMGDQSGCYR 139

  Fly   384 CKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQ------------ 436
            |               |..|.|:.    |...||.|.:..:..|..|.|..::
Human   140 C---------------GKEGHWSK----ECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLY 185

  Fly   437 --------------------YETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSS 481
                                ||.|.||.|:|                .::||        ...|.
Human   186 YNNAYGALDAYYKRCRAARSYEAVAAAAASV----------------YNYAE--------QTLSQ 226

  Fly   482 KPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPP 546
            .|....:|:              |::.......||                        |.|..|
Human   227 LPQVQNTAM--------------ASHLTSTSLDPY------------------------DRHLLP 253

  Fly   547 HPGSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVERSRSRSPLKRARSP------- 604
            ..|:.|.::::......|.              |.|:|     ...|.||||:||.:|
Human   254 TSGAAATAAAAAAAAAAVT--------------AASTS-----YYGRDRSPLRRATAPVPTVGEG 299

  Fly   605 ---GSDSDTSTRRNDALASASTVPDVAR 629
               |.:|:.|   ..:.|:.:::.|:||
Human   300 YGYGHESELS---QASAAARNSLYDMAR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	17/87 (20%)
		RRM3_Spen	397..467	CDD:240756	17/101 (17%)
		SPOC	630..789	CDD:311609	76/418 (18%)
RBM14-RBM4	NP_001185774.1	RRM1_CoAA	1..71	CDD:241052	7/19 (37%)
		RRM_SF	79..>113	CDD:302621	10/52 (19%)
		ZnF_C2HC	136..151	CDD:197667	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910