DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nito and rbm15b

DIOPT Version :9

Sequence 1:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_002935665.2	Gene:	rbm15b / 100495588	XenbaseID:	XB-GENE-961063	Length:	786	Species:	Xenopus tropicalis

Alignment Length:	867	Identity:	288/867 - (33%)
Similarity:	405/867 - (46%)	Gaps:	192/867 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GAGADRITIKIHNMKRSASR---SPGPASRSSLSRNSRSMGRGYDNGSGVPGDSPERLSPERMRR 68
            |.||.....:..:|||.:.|   |||.|.|   :|..|....|..:.|....:.|.:..
Frog    25 GDGAASSQQRDVSMKRQSERGEQSPGRAKR---ARERREEAGGAHHKSSGRRERPNQAG------ 80

  Fly    69 RLDRSPSRYGSPHREPYMRGPP--------PAERPA-GYKVLCVSALPPKAPDDFIEETLYREYK 124
               .|.|...|..|.|  |.||        |||.|. .||.|.:|.|....||..:|:.|:|.::
Frog    81 ---ASSSSSSSSSRRP--RDPPPRPLLLTAPAEAPGLEYKTLLISNLGSALPDPLLEDWLFRHFQ 140

  Fly   125 KFGDFSVRLAHDLD-ERVAYVCFRTPEDAREAKHHKPRLIIYDKMAIVEPVYKSTTRPEYRPRGH 188
            :|||.||:|:|..: .||||:.||.|.:||:|:|.|.|.::||:...||||:  |.:|..||...
Frog   141 RFGDISVKLSHTPELGRVAYINFRRPAEARQARHAKVRPVLYDRQLRVEPVF--TQQPTRRPEPS 203

  Fly   189 SMSPPDYERYHYSRSPMGQGVPLDHRRPPIDPYDRYGPPHMHPHAVHPRDYRPLHHDYPHPPRGP 253
            .:|......|..|.||....:                |..:...|.....|.||   |....||
Frog   204 PLSLTSLPSYPRSTSPRHLLL----------------PSSLTSTAASGDGYYPL---YEERVRG- 248

  Fly   254 PLHRGGHPHHLHGHAPPHQYAPMRPLAPRPHAPY--EKPESKKDKFPNYLHHVQPEDDPLSTRTL 316
                                           |.|  ....:..|:      .:.||||..:||.|
Frog   249 -------------------------------ATYGMSSTSTADDE------QLAPEDDHRATRNL 276

  Fly   317 FAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYIGK 381
            |.|||:..:::.:|||.|.|||.::::.||||..|.|.|:||:|:||||||||||:.:||:.:|:
Frog   277 FIGNLDHMVSEVDLRRAFDKYGPIEEVVIKRPGRGQGAAYAFLRFQNLDMAHRAKLAMSGRLLGR 341

  Fly   382 FQCKIGYGKVTPATRMWIGGLGAWTSVTQLEREFDRFGAIKKIEYQKGEPYAYIQYETVEAATAA 446
            ...||||||..|:||:|:||||..||:..|.|||||||:|:.::|.||:.:||||||:::||.||
Frog   342 NAMKIGYGKPNPSTRLWVGGLGPNTSLAALAREFDRFGSIRTVDYVKGDSFAYIQYESLDAAQAA 406

  Fly   447 VKEMRGFPLGGPERRLRTDFAEL------PGATPAAPFKSSK---P-PYD---ESALEYRRPEYD 498
            ..:||||.||  :||||.|||.:      ..|:..||.:::.   | ||:   ..|....|...|
Frog   407 CTQMRGFALG--DRRLRVDFATVSPDEAAAAASRYAPLQTTPYPLPLPYELLQPEAYSRHRTALD 469

  Fly   499 PYYEESAAYAPRGGYS----PYPPRG-----------GYRGRGGYRGRGRGMYHYHNDVHRPPHP 548
            |.........|...||    |:...|           |.|.|.|.||.|.|
Frog   470 PDLRVRDRTPPHLLYSDRERPFVEAGWVNSERRSSGQGARSRSGDRGGGGG-------------- 520

  Fly   549 GSLAGSSSSVPPPGGVEDEWRRPPGESYDRGARSSSREPGVER---------------------- 591
               .||||.      ..:|.||....|.||....:.|.|..:|
Frog   521 ---GGSSSK------TREERRRRRSLSSDRVRSRAERSPDRQRREPPERDPSTPPSPQHNHRPSS 576

  Fly   592 -SRSRSPL------KRARSPGSDSDTSTRRNDALASASTVPDVARKCSTVWTGALILKSSLFPAK 649
             .:.|.|.      :|...|......:.|::..:....|:|       .||.|.|:||:|.||..
Frog   577 QDKPRPPTPDPPQPRRNHHPRPPEPPAERQSPGVEKGRTLP-------PVWCGHLVLKNSCFPTY 634

  Fly   650 FHLTDGDTDIVESLMRDEEGKH-----NLRITQRLRLDPPKLDDVQKRI--ASSSSHAIFMGLAG 707
            .|..:||.|:..:|::|.....     .|:|.||||||.|||::|.:::  .::..:|:.:....
Frog   635 LHFLEGDRDVPGALLKDRSSTSGGSLAQLKIAQRLRLDQPKLEEVTRKVRQGTAGGYAVLLATQA 699

  Fly   708 STNDTNC-DDASVQTRPLRNLVSYLKQKEAAGVISL----LNKETEATGVLYAFPPCDFSTELLK 767
            ..|:... .:..:|.|.|||||||||||:|||||||    .||..:.:|:|||||||||. :|.:
Frog   700 PQNEGAIPGEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSNKGRDPSGMLYAFPPCDFH-QLYQ 763

  Fly   768 RTCHSLTEEGLKEDHLVIVVVR 789
            ::...|.  |..|::::||:|:
Frog   764 QSAQRLV--GKLEENMIIVLVK 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nito	NP_001286174.1	RRM	<56..>223	CDD:223796	58/176 (33%)
		RRM1_Spen	98..175	CDD:240754	35/77 (45%)
		RRM2_Spen	312..390	CDD:240755	41/77 (53%)
		RRM3_Spen	397..467	CDD:240756	40/69 (58%)
		SPOC	630..789	CDD:311609	67/170 (39%)
rbm15b	XP_002935665.2	RRM1_RBM15B	113..192	CDD:240998	35/78 (45%)
		RRM2_RBM15B	266..350	CDD:241000	45/83 (54%)
		RRM_SF	353..426	CDD:388407	44/74 (59%)
		SPOC	616..783	CDD:369497	68/176 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2190
OMA	1	1.010	-	-		QHG48807
OrthoDB	1	1.010	-	-		D215960at33208
OrthoFinder	1	1.000	-	-		FOG0003417
OrthoInspector	1	1.000	-	-		otm48863
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5131
SonicParanoid	1	1.000	-	-		X2309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110