DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2915 and AGBL2

DIOPT Version :9

Sequence 1:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	438	Identity:	89/438 - (20%)
Similarity:	138/438 - (31%)	Gaps:	156/438 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GNPPDQARYDNYRIYNVEFENQEQIELFQKLEEQSDSLTFIGHAREVGQKLSILVAAHRVADIAD 111
            ||.....|.|.|     |:|...:.:|:.....|    .|....:...:.     |.:|.. |.:
Human   275 GNLQKAVRVDTY-----EYELTLRTDLYTNKHTQ----WFYFRVQNTRKD-----ATYRFT-IVN 324

  Fly   112 LLK---TYKVKHRVLTYNFQEKIDRNLA------EVQ--PESIDASQLDWQHFFHLK-TIYEWLD 164
            |||   .|.|..:.|.|:..:...||:.      |::  ..:.|..|   |.|:.|. ||....|
Human   325 LLKPKSLYTVGMKPLLYSQLDANTRNIGWRREGNEIKYYKNNTDDGQ---QPFYCLTWTIQFPYD 386

  Fly   165 K----MVEKYPNRVTVLD--------------------MGSSTQGNAIKGVKLTS-------NAN 198
            :    ....||...|.|.                    :..|..||.:..:.:|:       .|.
Human   387 QDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAAA 451

  Fly   199 NKAIFIESGIHARE----WISPAAATYIINQLLTSQDPKVQQLAQDYNWIIFPCVNPDGYKYTFE 259
            .||:.:.:.:|..|    |:......:|:     |..|..|.|...:.:.:.|.:||||.
Human   452 KKAVVLSARVHPGESNGSWVMKGFLDFIL-----SNSPDAQLLRDIFVFKVLPMLNPDGV----- 506

  Fly   260 HDRMWRKNRQLFGTCR----GVDLNRNY--------PDHWNSTGSSSDPTRYDFAGPSAGSELET 312
                      :.|..|    |.||||:|        |..|.:...                   .
Human   507 ----------IVGNYRCSLAGRDLNRHYKTILKESFPCIWYTRNM-------------------I 542

  Fly   313 KRLIDFIRANAGKEQIKTYIALHSYSQM-LMFPYG--------YTKERV------SNYDDLQEFG 362
            |||::       :.::..|...|.:|:. .:|.||        :..|||      .|..|...|.
Human   543 KRLLE-------EREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLHERVFPLMLCKNAPDKFSFH 600

  Fly   363 KKASAAIKAENGRDYVSGSLFETIYPSSGGSMDWAHSEAGIPIAYTFE 410
            .......|.:.|               :|..:.|   ..||..:||.|
Human   601 SCNFKVQKCKEG---------------TGRVVMW---RMGILNSYTME 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	87/435 (20%)
		Propep_M14	63..133	CDD:280416	15/72 (21%)
		M14_CP_A-B_like	153..446	CDD:199844	63/321 (20%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	54/288 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810