DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2915 and Cpa4

DIOPT Version :9

Sequence 1:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001102816.1	Gene:	Cpa4 / 502736	RGDID:	1563619	Length:	421	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	132/454 - (29%)
Similarity:	230/454 - (50%)	Gaps:	52/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QWLVILCVAMAASGTNLDSGICPVAGDSGCRGNPPDQARYDNYRIYNVEFENQEQIELFQKLEEQ 80
            :||:..       |..:.:|||             .:.::...:::.:...|.::|   :||.|.
  Rat     2 KWLLFF-------GALIGTGIC-------------GRDKFFGDQVFRINVRNGDEI---RKLTEL 43

  Fly    81 SDS----LTFIGHAREVGQKLSILVAAHRVADIADLLKTYKVKHRVLTYNFQEKIDRNLAEVQ-P 140
            .:|    |..........:.:.|||.:..:..:...||:..:.:.|...|.|..:|....|:| .
  Rat    44 VNSDHFKLNVWKSPSTFDRPVDILVPSVSLLPVKSFLKSQGLDYSVTIDNLQALLDIEDEEMQHN 108

  Fly   141 ESIDAS-QLDWQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGVKLTSNANNK---A 201
            |..:.| ..::..:...:.||..:|.:...:|:..:.:.:|.:.:...:..:|.::....|   |
  Rat   109 EGRERSGDFNYGSYHSPEAIYHEMDSIATDFPDLASRVKIGETFEKRPMYVLKFSTGGGGKKRPA 173

  Fly   202 IFIESGIHAREWISPAAATYIINQLLT--SQDPKVQQLAQDYNWIIFPCVNPDGYKYTFEHDRMW 264
            |::.:|||||||||.|.|.:...:::|  .:||.|..:.:..:..:.|..|||||.||...:|:|
  Rat   174 IWLNAGIHAREWISQATAIWTARKIVTDYQKDPAVTSILEKMDIFLLPVANPDGYVYTQNQNRLW 238

  Fly   265 RK--NRQLFGTCRGVDLNRNYPDHWNST----GSSSDPTRYDFAGPSAGSELETKRLIDFIRANA 323
            ||  :|.....|.|.|.|||    ||::    |:|::|....:.|....||:|.|.::|||:.:.
  Rat   239 RKTRSRNPGSRCIGADPNRN----WNASFAGEGASNNPCSEVYHGSHPNSEVEVKSVVDFIQKHG 299

  Fly   324 GKEQIKTYIALHSYSQMLMFPYGYTKERVSNYDDLQEFGKKASAAIKAENGRDYVSGSLFETIYP 388
               ..|.:|.||||||:||:||||:.::..:.::|.:..:.|:.|:.:.:|..|..|....|:||
  Rat   300 ---NFKCFIDLHSYSQLLMYPYGYSVKKAPDAEELDDVARSAAKALASLSGTKYQVGPTCTTVYP 361

  Fly   389 SSGGSMDWAHSEAGIPIAYTFELRGPPDSQDL-FILPAVEIQPTASEAFTAIRAIVEAAAEKGY 451
            :||.|:|||: :.||..|:|||||   |:... |:|||.:|.|||.|.:..::.|:|...:..|
  Rat   362 ASGSSVDWAY-DNGIKYAFTFELR---DTGHYGFLLPASQIIPTAEETWQGLKVIMEHVRDNLY 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	121/400 (30%)
		Propep_M14	63..133	CDD:280416	15/73 (21%)
		M14_CP_A-B_like	153..446	CDD:199844	105/304 (35%)
Cpa4	NP_001102816.1	Propep_M14	28..99	CDD:280416	15/73 (21%)
Cpa4	NP_001102816.1	Peptidase_M14_like	117..419	CDD:299699	105/312 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8990
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750