DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2915 and Y47G6A.19

DIOPT Version :9

Sequence 1:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001379340.1	Gene:	Y47G6A.19 / 171921	WormBaseID:	WBGene00021645	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	455	Identity:	132/455 - (29%)
Similarity:	215/455 - (47%)	Gaps:	70/455 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VAGDSGCRGNPPDQARYDNYRIYNV-EFENQEQIELFQKLEEQSDSLTFIGHARE-VGQKLSILV 101
            :|..|.|:       .:..::::.| ...||:.:::.:..|..........||.. |...:.|:|
Worm    11 IAVHSSCQ-------EHGAFKVFRVLPTTNQQLLQMIRLFETADTDRADFWHAPSVVNGTVDIMV 68

  Fly   102 AAHRVADIADLLKTYKVKHRVLTYNFQEKID---RNLAEVQ-----PESIDA------------- 145
            |...    .|..:.|..||   .|.||..||   :.|.|.:     ..:.||
Worm    69 APEH----TDQFRQYLEKH---GYTFQVAIDDLHKLLIEKEGNLSTHSNDDAFFLKRLHDDVGFH 126

  Fly   146 SQLDWQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGVKLTSNA-NNKAIFIESGIH 209
            |:|....::....:..||:::.|..|:...::.:|::.:|..|.|:|...:. :.|.:.|::|||
Worm   127 SRLRMGEYYSYSVLSTWLERIAENMPDIAKLIKVGTTIEGRDILGLKFGKDTPDKKIVVIDAGIH 191

  Fly   210 AREWISPAAATYIINQLLT--SQDPKVQQLAQDYNWIIFPCVNPDGYKY-----TFEHDRMWRKN 267
            ||||.:...|:|.||.::.  .:||::|....:....|.|.:|||||:|     |....|||||:
Worm   192 AREWAAIHTASYFINLIVNGREEDPQIQNYLDNIVLYIIPVLNPDGYEYTRTDKTNPRARMWRKS 256

  Fly   268 RQ----LF-----GTCRGVDLNRNYPDHWNSTGSSSDPTRYDFAGPSAGSELETKRLIDFIRANA 323
            |.    .|     ..|.|||||||:...::..|:|..|....:.||||.||.|:|....|:.:..
Worm   257 RSPKACAFDGVRNSCCMGVDLNRNFDFRFSEIGASRYPCSEIYHGPSAFSEPESKAYSQFLTSLK 321

  Fly   324 GKEQIKTYIALHSYSQMLMFPYGYTKERVSNYDDLQEFGKKASAAIKAENGR----DYVSGSLFE 384
            |:  ::.||.||||||:.:  |.|:..:.:...|::|..:.|:.|:: |.||    .|..|:..|
Worm   322 GR--LEAYITLHSYSQLWI--YSYSHRKFTYAPDIEETRRVAAKAVQ-ELGRMYGTKYRHGTGPE 381

  Fly   385 TIYPSSGGSMDWAHSEAGIPIAYTFELRGPPDSQDL-----FILPAVEIQPTASEAFTAIRAIVE 444
            .||..||||.|||.....|..:||.|||  |..:.:     |:|...::.|||.|.:..:..:::
Worm   382 IIYAFSGGSTDWAKETLKIKYSYTIELR--PGYEGIIEWNGFVLDKNQLIPTAKETWAGVTVVLD 444

Fly 445 444
Worm 445 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	127/431 (29%)
		Propep_M14	63..133	CDD:280416	19/74 (26%)
		M14_CP_A-B_like	153..446	CDD:199844	104/318 (33%)
Y47G6A.19	NP_001379340.1	Propep_M14	32..102	CDD:396700	20/76 (26%)
		M14_CP_A-B_like	134..446	CDD:349433	104/318 (33%)
		ShK	467..504	CDD:396228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830