DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2915 and T06A4.3

DIOPT Version :9

Sequence 1:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001021611.1	Gene:	T06A4.3 / 171668	WormBaseID:	WBGene00020283	Length:	505	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	142/463 - (30%)
Similarity:	235/463 - (50%)	Gaps:	54/463 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TQWLVILCVAMAASGTNLDSGICPVAGDSGCRGNPPDQARYDNYRIYNVEFENQEQIELFQKLEE 79
            |..|:.||.:..:..|                         .::.:|.:..::|...:..|:|.:
Worm     5 TSLLIFLCFSAVSLST-------------------------QSFAVYRLLPKSQTDFQAIQRLYK 44

  Fly    80 QS--DSLTFIGHAREVGQKLSILVAAHRVADIADLLKTYKVKHRVLTYNFQEKI------DRNLA 136
            .:  ..|.|....::......::|.........|.|:...:.: :.|.:..|.:      ::.|:
Worm    45 NATDHDLNFWKTGKDKHGFWDVMVDMKNSKYFLDFLQVNDISY-IKTIDDVEGLITKHENNKTLS 108

  Fly   137 EVQPESID---ASQLDWQHFFHLKTIYEWLDKMVEKYPNRVTVLDMGSSTQGNAIKGVKLTSNAN 198
            .:.|...|   ::..|:..:...:.:.:|:.::|.|||..|..:.:|.:|:|..|.||::..::.
Worm   109 NMFPRLWDDSSSAHYDFHTYGSYQRMTDWMKQLVVKYPKMVQYISIGKTTEGRNIDGVEIGGDSR 173

  Fly   199 NKAIF-IESGIHAREWISPAAATYIINQLLT-SQDPKVQQLAQDYNWIIFPCVNPDGYKYTFE-- 259
            .|.|| |:.|||||||.:|..|.:.|:||.: :.:|.:::|..:..:::.||:|||||::|..
Worm   174 TKKIFWIDGGIHAREWAAPHTALFFIHQLTSRANEPGIKKLLNEITFVVVPCLNPDGYEFTRSST 238

  Fly   260 --HDRMWRKNR-------QLFG---TCRGVDLNRNYPDHWNSTGSSSDPTRYDFAGPSAGSELET 312
              |.|:|||||       .::|   .|||||||||:..|:..:|:|.||....:.|||..||.|.
Worm   239 NPHVRLWRKNRSKMQCRKDIWGRNRCCRGVDLNRNFDFHFRESGTSDDPCSEIYQGPSPFSEPEA 303

  Fly   313 KRLIDFIRANAGKEQIKTYIALHSYSQMLMFPYGYTKERV-SNYDDLQEFGKKASAAIKAENGRD 376
            |.:.|.:.:...|.:...||.||:|||:.:.|||:.|:.. .:..||.|.||||:.|:|...|..
Worm   304 KAVRDALLSQRYKGRTDAYITLHTYSQIWIHPYGHKKDAYPGDIKDLYEVGKKAAQALKRVYGTK 368

  Fly   377 YVSGSLFETIYPSSGGSMDWAHSEAGIPIAYTFELRGPPDSQDLFILPAVEIQPTASEAFTAIRA 441
            ||.||..:|:||:||||.|||..||.:...|..|||....:.|.|||...|:.|||.|.:..:|.
Worm   369 YVVGSGADTLYPASGGSEDWAKHEAKVKFVYLLELRPDEKNWDGFILDEKELIPTARETWEGVRV 433

  Fly   442 IVEAAAEK 449
            :.||..::
Worm   434 VAEAVLDR 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	132/410 (32%)
		Propep_M14	63..133	CDD:280416	10/77 (13%)
		M14_CP_A-B_like	153..446	CDD:199844	121/309 (39%)
T06A4.3	NP_001021611.1	Propep_M14	31..98	CDD:366995	10/67 (15%)
		M14_CP_A-B_like	128..438	CDD:349433	121/309 (39%)
		ShK	468..505	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I1500
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47975
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm4737
orthoMCL	1	0.900	-	-		OOG6_100142
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16949
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.910