DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2915 and AGBL1

DIOPT Version :9

Sequence 1:	NP_610338.1	Gene:	CG2915 / 35754	FlyBaseID:	FBgn0033241	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001373023.1	Gene:	AGBL1 / 123624	HGNCID:	26504	Length:	1121	Species:	Homo sapiens

Alignment Length:	311	Identity:	70/311 - (22%)
Similarity:	113/311 - (36%)	Gaps:	84/311 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 PESIDASQLDWQHFFHLKTIYEWLDKMVEKYPN------RVTVL--DMGSSTQGNAIKGVKLTS- 195
            |.|.|...|.:.:.:....:...|| ::||..|      |..||  .:|    ||....|.:|:
Human   720 PHSEDVCYLAYHYPYTYTALMTHLD-ILEKSVNLKEVYFRQDVLCQTLG----GNPCPLVTITAM 779

  Fly   196 NANNKAIFIESGIH-------AREWISPAAATYIIN---QLLTSQDPKVQQLAQDYNWIIFPCVN 250
            ..:|....:|...|       ||.....:.|::::.   :.|.|.||..:.|.:::.:.|.|.:|
Human   780 PESNSDEHLEQFRHRPYQVITARVHPGESNASWVMKGTLEFLVSSDPVARLLRENFIFKIIPMLN 844

  Fly   251 PDGYKYTFEHDRMWRKNRQLFGTCR----GVDLNRNYPDHWNSTGSSSDPTRYDFAGPSAGSELE 311
            |||.               :.|..|    |.||||    .|.|..:...||.|...|
Human   845 PDGV---------------INGNHRCSLSGEDLNR----QWLSPSAHLQPTIYHAKG-------- 882

  Fly   312 TKRLIDFIRANAGKEQIKTYIALHSYSQML-MFPYGYT-KERV---------------SNYDDLQ 359
                :.:..::.|:..: .:...|.:||.. :|.||.: ||.:               .||..|.
Human   883 ----LLYHLSSIGRSPV-VFCDFHGHSQKKNVFLYGCSIKETLWQAACTVGTSTILEEVNYRTLP 942

  Fly   360 EFGKKASAAIKAENGRDYVSGSLFETIYPSSGGSMDWAHSEAGIPIAYTFE 410
            :...|.:.|....:     ...|.|....|:...:.|  .|.|:..:||.|
Human   943 KILDKLAPAFTMSS-----CSFLVEKSRASTARVVVW--REMGVSRSYTME 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2915	NP_610338.1	MpaA	50..433	CDD:225421	70/311 (23%)
		Propep_M14	63..133	CDD:280416
		M14_CP_A-B_like	153..446	CDD:199844	66/298 (22%)
AGBL1	NP_001373023.1	Pepdidase_M14_N	596..730	CDD:407865	4/9 (44%)
AGBL1	NP_001373023.1	M14_Nna1	754..1019	CDD:349477	61/276 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810