Protein Alignment CG2906 and METTL25B

DIOPT Version :10

• Sequence 1: NP_001097225.1
• Gene: CG2906 / 35753
• FlyBaseID: FBgn0033240
• Length: 456
• Species: Drosophila melanogaster
• Sequence 2: NP_057081.3
• Gene: METTL25B / 51093
• HGNCID: 24273
• Length: 475
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 150/466 - (32%)
• Similarity: 228/466 - (48%)
• Gaps: 34/466 - (7%)

  Fly     5 REKLERGL-ELLKKYEWLLDAYVLDFFIDDHWSKLPGNWQKHLESIPLENLGDLL-----KNENH 63
            |::|...| .:|..|..:||||:::||.|:.|..||.:||:.|:.:....|..:|     :.|..
Human    14 RKQLAVNLTRVLALYRSILDAYIIEFFTDNLWDTLPCSWQEALDGLKPPQLATMLLGMPGEGEVV 78

  Fly    64 NTQLTWPLDLKNLQEELRKLCVSRVPKHPPDNSLPCSLLDHP----KLKYVFLKRVKPKKHHEII 124
            ..:..|||.|..|:.....|..:|:|..    ..|...|::|    :|...|.|.|:|||.|||.
Human    79 RYRSVWPLTLLALKSTACALAFTRMPGF----QTPSEFLENPSQSSRLTAPFRKHVRPKKQHEIR 139

  Fly   125 RMAEICALSQQKTPVDFIVDFGAGVGHLARVLGYGYGLRVCCYEMQPDLNQQAREIDLKLESMAA 189
            |:.|:.......|....:||.|:|.|||:|.:..|.||.|...|....|.::|:.:|.:|.....
Human   140 RLGELVKKLSDFTGCTQVVDVGSGQGHLSRFMALGLGLMVKSIEGDQRLVERAQRLDQELLQALE 204

  Fly   190 KHLSED----ETTHFQRPVHLTHRLESSTKPEQFLSSIRQALQLTDDNFRFGVIGLHPCGNLGPT 250
            |....:    :|:....|.|:...::.:...|:.|..:....|   ...|..:.|||.||:|...
Human   205 KEEKRNPQVVQTSPRHSPHHVVRWVDPTALCEELLLPLENPCQ---GRARLLLTGLHACGDLSVA 266

  Fly   251 LMRMFLGCPQAKFLNFVGCCYQKMTTQSTHPREHVHGYPLSSELKDKNECQLSYEAREISCHAME 315
            |:|.|..||:...|..|||||.|::...        |||||..:......:|.|..||.:|||:|
Human   267 LLRHFSCCPEVVALASVGCCYMKLSDPG--------GYPLSQWVAGLPGYELPYRLREGACHALE 323

  Fly   316 VYHDRLRMGDYQHLRIHSLRAAAERIIVHQFPELRHCALRNVKYSPGMTFHQYFQKAVQGTRFEA 380
            .|.:||:... ..||.|..|||.|.:|....||||...::.:.....:...:|.|:.:|..   .
Human   324 EYAERLQKAG-PGLRTHCYRAALETVIRRARPELRRPGVQGIPRVHELKIEEYVQRGLQRV---G 384

  Fly   381 LDSR-TLSNQQTETDLANWQRIVSFYTLRLMMAPLVESIILYDRCLFLMENDCQVQIEAIFDPRL 444
            ||.: .|:....:..:|...|:|:|::|.|::|||||::||.||.|:|.|.....::..||.|.|
Human   385 LDPQLPLNLAALQAHVAQENRVVAFFSLALLLAPLVETLILLDRLLYLQEQGFHAELLPIFSPEL 449

  Fly   445 SPRNHITRAVK 455
            ||||.:..|.|
Human   450 SPRNLVLVATK 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2906	NP_001097225.1	Methyltransf_32	118..277	CDD:379330	51/162 (31%)
METTL25B	NP_057081.3	Methyltransf_32	133..293	CDD:379330	51/162 (31%)