Protein Alignment CG2906 and Mettl25

DIOPT Version :10

• Sequence 1: NP_001097225.1
• Gene: CG2906 / 35753
• FlyBaseID: FBgn0033240
• Length: 456
• Species: Drosophila melanogaster
• Sequence 2: XP_011241713.1
• Gene: Mettl25 / 216292
• MGIID: 3041259
• Length: 646
• Species: Mus musculus
• Alignment Length: 654
• Identity: 130/654 - (19%)
• Similarity: 222/654 - (33%)
• Gaps: 234/654 - (35%)

  Fly     4 VREKLERGLELLKKYEWLLDAYVLDFFIDDHWSKLPGNWQKHLESIPLENLGDLLKNE------- 61
            :.:||:..|..|:....:..|:.:||:....|        :.|..:|.|::...|:..
Mouse    19 LHDKLQGLLSFLRGALAISSAHTVDFYTKSVW--------QELVDLPPESVLAALRESAVEAEPR 75

  Fly    62 -----NHNTQLTWPLDLKNLQEELRKL----CVSRVPKH---------PPDNSLPCSLLDHPKLK 108
                 :..|:|.     |...|..:||    ..:|..||         .|...|..:|..:.:.:
Mouse    76 EAETGSGFTELP-----KIFCETSQKLLSVEAFARTAKHYSVQNLGLCTPSEQLLTALQGNKRQR 135

  Fly   109 ----YVFLKRVKPKKHHEIIRMAEI-------CALSQQKTPVDFIVDFGAGVGHLARVLGYGYGL 162
                ...::.:..||.||:..|:|:       |.|.|       |:|.|:|.|:|:..|...|||
Mouse   136 VDENVKAIEFMNTKKSHEVQAMSELICSIADYCGLKQ-------IIDVGSGKGYLSSFLSLKYGL 193

  Fly   163 RV-----------------------------------------------------CCYEMQ---- 170
            .|                                                     |..:.:
Mouse   194 NVYGIDSSNTNTHGAKERNRKLKKHWSLYHPHSRADANGWASERPRELKVPKGVECKGDAESVQR 258

  Fly   171 --------------PDLNQQAREIDLKLESMAAKHLSEDETTHFQRPVHLTHRL----------- 210
                          ||.:..|..:..|.:.......:|:|..:|:....|...|
Mouse   259 SRLGNPDLSATDGLPDFSGSAISVIRKQQKNVLAQPAEEENLYFEDAFSLIDFLPVDAIEPTSSQ 323

  Fly   211 -----ESSTKPEQ------------------FLSSIRQALQLTDDNFRFGVIGLHPCGNLGPTLM 252
                 :|..:.|:                  |:::..|...:.:|.....::|||.||:|.|:.:
Mouse   324 VQNTEKSGLRKERRNTASKARDSSIYSPLTSFITADSQLHDIIEDLEDCLMVGLHTCGDLAPSTL 388

  Fly   253 RMFLGCPQAKFLNFVGCCYQKMTTQSTHPREHVH---------GYPLSSELKDKNECQLSYEARE 308
            |:|....:.|.:..|||||..::.:.    |:.|         |:|:...||::..| ....||.
Mouse   389 RIFTSKAEVKAVCSVGCCYHLLSEEF----ENQHKDRCANENWGFPMCHYLKEERWC-CGRNARM 448

  Fly   309 ISCHAMEVYHDRLRMGDYQHLRIHSL--RAAAERIIVHQFPELRHCALRNVK-YSPGMTFHQY-- 368
            .:|.|::    |:.:|  |.|...||  ||..:.|| ..:..:..|.....| ||...:|.:|
Mouse   449 SACLALQ----RVAVG--QGLPTESLFYRAVLQNII-KDYYGISKCEQHVGKIYSKCSSFLEYVR 506

  Fly   369 --------------FQK-----AVQGTRFE--ALD------------------------SRTLSN 388
                          ||:     .|..:|:|  .||                        |..:..
Mouse   507 MSLKKLGLDESKRHFQELQSVCCVLCSRWEQNLLDVFYVRLIYDRPGCSLCPMVGFLNVSEEIIM 571

  Fly   389 QQTETDLANWQRIVSFYTLRLMMAPLVESIILYDRCLFLMEND--CQVQIEAIFDPRLSPRNHIT 451
            ...|........:.:|..|::::||.:|::||.||..:|.|.|  ....:..:|||..|||.:..
Mouse   572 DYYENYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQDGVAWSALVKLFDPVQSPRCYAV 636

  Fly   452 RAVK 455
            .|:|
Mouse   637 IALK 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2906	NP_001097225.1	Methyltransf_32	118..277	CDD:379330	50/270 (19%)
Mettl25	XP_011241713.1	AdoMet_MTases	149..413	CDD:473071	50/270 (19%)